All issues
Volume 22, Issue 4
Displaying 1-12 of 12 articles from this issue
- |<
- <
- 1
- >
- >|
-
[in Japanese]1993 Volume 22 Issue 4 Pages 1143
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (152K) -
J UCHINO, M MATSUSHITA, H MATSUE, M TAKAHASHI, M NISHIKAWA, M KOIKE, K ...1993 Volume 22 Issue 4 Pages 1145-1149
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (715K) -
M ESASHI1993 Volume 22 Issue 4 Pages 1150-1156
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (4587K) -
Quantitative investigation of oxygen transporting rate of NRC and its safety in anemic model rabbitsY OGATA, H GOTO, K SAKAGUCHI, K SUZUKI, T KAMITANI1993 Volume 22 Issue 4 Pages 1157-1161
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSNeo Red Cells (NRCs) prepared by encapsulating Stroma Free Hemoglobin (SFH) together with the allosteric effector in liposomes, sufficiently function as artificial oxygen carriers under physiological condition. In animal models, rabbits were carried out twice bleeding and followed infusion of 6%-hydroxy ethyl starch. With this procedure, rabbits were made anemic (Hb conc. 1.6g/dl, Hct 5.0%), then this anemic model rabbits were infused with 40ml/kg of NRC suspention. The anemic rabbits, receiving NRCs showed recovery from anemic condition within 4-5h after exchange transfusion (ET) and were remained over 20h. Cardiac output was increased from 0.5 to 0.6-0.8l/min after ET, but remained this over 20h. Rabbits lived normally without any assist up to 6 months until sacrificed after ET. NRCs oxygen transporting rate (OTR) was 10.5ml/min after ET, the OTR of NRCs was reduced to 50% at 48h post-exchange due to clearance of NRCs by the reticuloendotherial system and methemoglobin formation, but after 24h, OTR of own blood begun to increase such that the animals could become independent of NRC, with full recovery within 2 weeks. The pathological diagnosis of rabbits indicated that phagocytosis of NRC by Kupffer's cells in liver and splenocytes, but there were no appearance of toxically damage. The present investigations clearly indicate that NRCs are efficacious oxygen carriers without causing serious adverse reaction.View full abstractDownload PDF (674K) -
A YAMADA, M FUSE, T AOYAGI, H HOSAKA, H YANAGISAWA, H TOMA1993 Volume 22 Issue 4 Pages 1162-1167
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe object of our work was the development of a monitoring device for measuring the volume of urine in the bladder to signal in advance the need to urinate and so help prevent urinary incontinence. A high frequency electric current of 50kHz transmitter was applied to a pair of terminals placed on the surface of a human body. The constant current was 2mA (p-p). A pair of voltage electrodes were placed in the path of the electric current to pick up high-frequency voltage signals. Impedance (ΔZ) was measured on one channel simultaneously. A human volunteer was tested. The best position of current electrodes was found to be over both femoral joints. Positioning the voltage electrode above the bladder on the lower abdomen was most efficient for detecting levels of urine. It can be seen that as the bladder gradually fills with urine, base impedance (Z0) decreases, and AC ΔZ, due to respiration, also decreases. These most precise value was able to use for the sake of prevention of urinary incontinence. The urinary incontinence was prevented by the alarm of both light and sound. The reappearance of data and stability of that was remarkably good from experimental results. The change of urinary volume which is related to the respiratory change of both the naturally stayed urine and normal urination was reflected in the state of naturally stayed urine. The alarm level which foretelled both naturally stayed urinary time and normally urinary time was examined. After that, when alarm level was decided within the range of impedance change, from 60 to 70%, the possibility of prediction of urination will be suggested.View full abstractDownload PDF (6019K) -
K KUBO, Y OHKAWA, S KOIKE, H NOGAKI, K MURASE1993 Volume 22 Issue 4 Pages 1168-1171
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSWe performed St. Jude Medical (SJM) prosthetic valve implantation using the Dacron cuff or the Teflon cuff, and compared the two kinds of cuffs regarding influence on postoperative acute hemolysis. Respective numbers of patients using the Dacron cuff and the Teflon cuff were as follows: 11 and 9 in mitral valve replacement (MVR); 24 and 18 in aortic valve replacement (AVR); and 8 each in double valve replacement (DVR). As regarding age and sex distribution, and pre- and postoperative hemodynamic data in each group, there was no significant differences between the Dacron and Teflon cuffs. Postoperative LDH level was found as AVR<MVR7lt;DVR. In MVR and DVR groups, the LDH level was significantly lower in cases done with the Teflon cuff than those with the Dacron cuff. The present study suggest the Teflon cuff superior to the Dacron cuff in St. Jude Medical valve implantation.View full abstractDownload PDF (1609K) -
H IWATA, N OGAWA, J MIZOGUCHI, T TAKAGI1993 Volume 22 Issue 4 Pages 1172-1176
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSTransplantation of genetically modified cells is an attractive method of treating diseases. The feasibility of this method has been accepted because of the technical progress in DNA recombination of the last 20 years. However, few in vivo studies have been reported. In this study, CHO cells were transduced to release insulin by gene transfer and were implanted into diabetic mice intraperitoneally. We compared the effects post-transduction cell preparation, such as singly dispersed cells, cells on microcarriers, and microencapsulated cells, on the control of glucose metabolism in diabetic mice. When singly dispersed cells were implanted, only 2 of the 11 recipients demonstrated normoglycemia. The blood glucose levels of the other 9 mice were not normalized. Cells on microcarriers could normalize blood glucose levels of all recipient mice. In the case of implantation of microencapsulated cells, no drastic effects were observed in blood glucose levels. The in vivo function of genetically modified cells highly depends on the method of post-transduction preparation.View full abstractDownload PDF (1921K) -
-Applications of a muscle powered pump for acute severe cardiac failureT HIRAYAMA, H SUESADA, T FUJIKAWA, T YOMO, H SHIMIZU, S ISHIMARU, K FU ...1993 Volume 22 Issue 4 Pages 1177-1184
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSMany studies on cardiac assist devices using skeletal muscle powered pumps (SMPP) recommend preconditioning for 6-9 weeks as a countermeasure to prevent skeletal muscle fatigue. Therefore this method does not seem to be suitable in cases of acute severe heart failure. We performed experiments to develop an alternately-driven twin SMPP as a cardiac assist device. In order to obtain an adequate alternate SMPP driving pattern, basic experiments were performed. The hydrodynamic function of SMPPs, prepared by rolled pedunculated sartorius muscle, was studied. The experiments showed that repetition of 30min drive and intermission was the best pattern for SMPP driving. Hydrodynamic changes in 30-min alternately-driven twin SMPP using latissimus dorsi muscle (LD) and pectoralis major muscle (PM) for three hours were compared between roll-type and insertion-type pumps. The pumping flow markedly declined after a few minutes of driving of the roll-type twin SMPP. On the contrary, it remained satisfactory until immediately before finishing the third 30-min drive of the insertion-type pump. We concluded that the insertion-type twin SMPP using LD and PM driving, alternately every 30min, could be useful as cardiac assist devices without requiring preconditioning.View full abstractDownload PDF (4146K) -
M YOSHIDA, Y TAKENAKA, Z YAMAZAKI, M HIRAISHI, Y IDEZUKI, N INOUE, F K ...1993 Volume 22 Issue 4 Pages 1185-1189
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSA new bilirubin adsorbent for direct hemoperfusion (DHP/BR) has been developed. Adsorption capacity of DHP/BR for bilirubin was investigated using plasma obtained from a patient with hyperbilirubinemia, in vitro, DHP/BR had a sufficient adsorption rate of bilirubin, while platelets sufficiently passed through the DHP/BR column during in vitro hemoperfusion with fresh bovine blood. Moreover, reduction rate of total bilirubin was about 60% during DHP/BR hemoperfusion test using doge with hyperbilirubinemia. From the above-mentioned experimental results, we conclude that DHP/BR is a promising adsorbent for direct hemoperfusion in order to remove bilirubin from hyperbilirubinemia.View full abstractDownload PDF (782K) -
-Significance of INR in therapeutic controlT OSADA, M CHO, K MAGARI, H FUKUSHIMA, T KUDO, K FURUKAWA1993 Volume 22 Issue 4 Pages 1190-1192
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSIt has been traditional to use thrombotest (%) to monitor warfarin therapy in Japan. The adoption of a uniform calibration system, in which the prothrombin time ratio is expressed in terms of the international normalized ratio (INR), was recommended in 1984. This INR system can be employed with same calibration if the thrombotest (%) is used. It is significant to standardize the monitoring system in anticoagulant therapy. The therapeutic range for oral anticoagulant therapy in patients with prosthetic heart valves is a PT-INR of 3.0 to 4.5 in the several recommendations. However, the optimal therapeutic range in Owren's reports is a thrombotest result of 10% to 25%, same as therapeutic range in Japan, which corresponded to a PT-INR of 2.8 to 1.5. This less intense therapeutic range has made no increasing in thromboembolism in Japanese reports. Therefore, it is doubtful to employ the more intence therapeutic range. It is necessary to confer the optimal intensity in accordance with additional clinical trials in Japan.View full abstractDownload PDF (463K) -
-The role of high right atrial pressure on renal insufficiency during left univentricular support-H AKAMATSU, H ARAI, T SAKAMOTO, A SUZUKI1993 Volume 22 Issue 4 Pages 1193-1198
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSAlthough clinical experience showed the effectiveness of LVAD for maintaining systemic flow and pressure on postcardiotomy cardiogenic shock patients, renal insufficiency might likely progress when the right atrial pressure (RAP) was high. The influence of increased venous pressure on renal circulation and function was studied using eight adult mongrel dogs. An occlusion balloon catheter was applied selectively in left renal vein to obtain high renal vein pressure (RVP), simulating clinical settings of high RAP with normal blood pressure (BP) and cardiac output (CO). Renal blood flow, urine output and free water clearance of left kidney (RVP=25.1±1.6mmHg) were significantly lower than those of right kidney (RVP=2.6±0.7mmHg), despite of normal BP and CO. To avoid the progression of renal insufficiency, early application of RVAD would be useful for the patient who is supported by LVAD and has high RAP.View full abstractDownload PDF (647K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1993 Volume 22 Issue 4 Pages 1199-1202
Published: August 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (679K)
- |<
- <
- 1
- >
- >|