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Volume 6 (1977)
- Issue 6 Pages 265-
- Issue 5 Pages 205-
- Issue 4 Pages 151-
- Issue 3 Pages 101-
- Issue 2 Pages 55-
- Issue 1 Pages 1-
Volume 6, Issue 2
Displaying 1-10 of 10 articles from this issue
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[in Japanese]1977 Volume 6 Issue 2 Pages 55
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (172K) -
Noriya AKAMATSU1977 Volume 6 Issue 2 Pages 57-61
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
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T. HIRANO, S. TAKENAKA, T. FUEKI, H. OHASHI, S. SHIMABUKURO, N. OTA, A ...1977 Volume 6 Issue 2 Pages 62-67
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSAs the first step of miniaturization of the artificial kidney, two methods are feasible for the reduction of dialysate volume available for hemodializer. Purification of the dialysate by use of the absorbents is the one. However, this method has disadvantage in that there are no absorbents, at present, which have selective affinity for urea. The other one is to try to recover the pure water from the dialysate by means of reverse osmosis process. Satisfactory rejection of urea has been reported by use of this method employing the membranes made of cellulose acetate butyrate, which has been also confirmed by simulation experiment.
Our experiment was performed on the mongrel dogs by the method of water recovering hemodialysis system by the reverse osmosis process. Acute and artficial hyperuricemia and hypercreatininemia were produced by the administion of exogenous urea and creatinine.
The result obtained was as follows; Rejection ratio of urea by the cellulose acetate butyrate was 91 to 97%, and that of electrolytes was, except for calcium, 93 to 100%. Therefore, the filtrate produced by reverse osmosis process was pure water with a little amounts of electrolytes. Accoding to this result, pure water from dialysate as produced during hemodialysis can be recovered by using this method.View full abstractDownload PDF (621K) -
A. SAKAI, M. ENDO, K. OHARA, H. NAGARA, N. FUJIWARA, H. HAYASHI, S. KO ...1977 Volume 6 Issue 2 Pages 68-74
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe effects of intraaortic balloon pumping (IABP) on the acute mitral insufficiency and ventricular septal perforation were studied in 21 mongrel dogs.
Mitral regurgitation was made by left ventrcculo-atrial extracardiac bypass with electro-magnetic flow meter. Ventricular septal perforation was simultaneously made by extracardiac bypass between left ventricle and right ventricle. By that method, the influence of IABP on regurgitant and shunt flow was clearly documented.
IABP reduced left ventricular pressure by 9 to 12.8% and augmented cardiac output by 3 to 16%. Mean aortic root diastolic pressure was elevated in average 11mmHg. Regurgitant flow was reduced by 12.6-14.6%. L-R shunt flow was reduced by 18%. There were not significant deference between normal and ischemic dogs.
Effects of IABP reducing regurgitant and shunt flow are dependent on decrement of the impedance to left ventricular ejection.
It was concluded in this experiment that IABP reduced left ventricular systolic pressure, thereby reduced regurgitant and shunt flow.View full abstractDownload PDF (2481K) -
T. OHSHIRO, S. D. HONG, G. KOSAKI, S. FUNKOSHI, T. OHMURA1977 Volume 6 Issue 2 Pages 75-79
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSSevere hemolysis may cause the various complications, such as acute renal failure. In these cases, if free hemoglobin could be removed promptly from the body, the risk might be lowered.
For this purpose, we have devised a filter containing immobilized haptoglobin which was used as affinity adsorbent of free hemoglobin. Haptoglobin, which was prepared from human plasma in our group, was immobilized to human fibrin polymer formed by fibrinogen-fibrin conversion in the presence of thrombin.
The results were as follows:
1. Fibrin particles (50-150u) kept the more suitable solidity than sepharose particles in circulation.
2. Haptoglobin binding capacity of fibirn was 460mgHp/g under 5mMol glutaraldehyde, but 180 mgHp/g under no glutaraldehyde. This capacity decreased under the high concentration of glutaraldehyde.
3. Hemoglobin adsorbent capacity of fibrin immobilizes haptoglobin was 58 mgHb/g in vitro, and about 30mgHb/g (1.7mgHb/ml) in extracorporeal circulation on rabbit.
This study suggested the possible use of immobilized haptoglobin. Now, we are trying to develop more practical application.View full abstractDownload PDF (557K) -
M. YOKOYAMA, M. ENDO, M. SEKIGUCHI, T. IMAI, M. HORI1977 Volume 6 Issue 2 Pages 80-82
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThree months following implant of Arco pacemaker (L-I-3D) in 61 year old female, the pacing rate showed interesting changes. The automatic pacing rate of 71/min. suddenly changed to 77/min. and suddenly returned to 71/min. It also occurred vice versa.
Rate changes appeared frequently. The patient never presented any other rate except for 71 or 77 min. This phenomenon, very rare complication, was considered due to the trouble of pacemaker reed switch.View full abstractDownload PDF (1966K) -
Elastic fibers in neo-arterial wallY. NOISHIKI, Y. YAMANE1977 Volume 6 Issue 2 Pages 83-87
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSElastic fibers in neo-arterial walls of polyester vascular prostheses were examined under both light and electron microscopes from 1 to 1240 days after implantation in the thoracic aortae of 202 dogs.
Elastic fibers were noticed in the close neighbourhood of smooth muscle cells by means of transmission electron microscope. By light microscopic observation of specimens stained by resorcin-fuchsin, the fibers were found only in the smooth muscle cell layer beneath endothelial cells. The earliest appearance of elastic fibers was near smooth muscis cells at an anastomotic line of a specimen removed 18 days after implantation. These results supported a theory that elastic fibers were synthesized by smooth muscle cells. Under light microscopic observation of cross section, three dimentional network structure of the elastic fibers could be observed and the arrangement of curved and long fibers of them were found in rows uniformly parallel to the direction of smooth muscle cells, whose pattern of arrangement was dependent on the tension to which they were subjected. The cooperative action of elastic fibers and smooth muscle cells seems to result in contractions that perform their characteristic function of neo-arterial walls, and these results indicate the biological mechanism of adaptation of the living body to the vascular prosthesis.View full abstractDownload PDF (4554K) -
Conparative study on methods of enzyme treatment and their tensile strength testH. SAITO1977 Volume 6 Issue 2 Pages 88-92
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe tensile strength of treated bovine grafts was comparatively evaluated regarding to enzyme used, its activating time and tanning method.
A quality of enzyme was not a significant factor and the only difference was related to its activation time. As a result nynhidrin test, tensile test and histological analysis, activation time of 2 1/2 hours was considered to be appropriate in 1% ficin and 3 1/2 hours in 1.5% papain. As for the tanning agents, neo-chrome was relatively superior to others in terms of flexibility. No difference was observed between glutar aldehyde and formaldehyde.View full abstractDownload PDF (5142K) -
M. MATSUDA, N. TATSUTA, N. DAITOH, K. YAMADA, M. AOSHIMA, Y. HIKASA1977 Volume 6 Issue 2 Pages 93-97
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSHeparin is widely used as anticoagulant during extracorporeal circulation but it is difficult to determine its concentration in whole blood. For control of heparin administration during cardiopulmonary bypass, we introduced activated coagulation time (ACT) which was firstly described by Hattersley in 1966.
ACT is whole blood clotting time after mixing with diatomaseous earth and is obtained rapidly than Lee-White clotting time. In this study, Hemochron 800, automated instrument for detecting blood coagulation, was used and ACT obtained by this instrument was called Hemochron Time.
The study group consists of 27 patients who underwent open-heart surgery with cardiopulmonary bypass in our clinic. Hemochron Time of non-heparinized blood was 118.9 seconds (mean) and after heparinization with 3mg per kg of body weight, Hemochron Time was 289.2 seconds (mean). During cardiopulmonary bypass heparin was administered so as to keep Hemochron Time between 300 and 400 seconds. At the end of bypass Hemochron Time was also used as indicator for determining protamine dose. Under control of heparin administration with the use of Hemochron 800, 2mg of protamine per kg of body weight returned Hemochron Time to preoperative value and coagula were seen in operative field.
After introduction of this method, the amount of heparin and protamine used were decreased. Hemochron test is useful and easily performed at bedside.View full abstractDownload PDF (2365K) -
[in Japanese]1977 Volume 6 Issue 2 Pages 98
Published: April 15, 1977
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (114K)
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