Jinko Zoki
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
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Volume 11, Issue 6
Displaying 1-50 of 103 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 923
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.923
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 925-928
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.925
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  • Improvement of activated charcoal sheet (UPC) for fulminant hepatic failure
    H. KAWANISHI, M. SUGIYAMA, M. NISHIKI, H. EZAKI, T. CHO, S. KIMURA, T. ...
    1982 Volume 11 Issue 6 Pages 929-932
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.929
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    A new hepatic support system has been developed in which powdered activated charcoals are embedded porous polyetherurethane sheet (UPC) with thickness about 200μm. UPC is superior to bead type charcoal (10-fold) and Amberlite XAD-7 (5-fold) for the adsorption of Bilirubin (Bil) in vitro. Hemoperfusion with jaundice dogs, the maximum removal rate of Bil was about 80% of inital.
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  • STUDY OF SILICONE COATED ACTIVATED CHARCOAL
    O. OTSUBO, M. NOMURA, T. WATANABE, I. TAKAHASHI, T. MAEDA, N. TAKAI, H ...
    1982 Volume 11 Issue 6 Pages 933-936
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.933
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    The activated charcoal which is derived from thermosetting resin, was further coated with silicone in order to utilize clinically safely. The charcoal is more rigid than the most kinds of activated charcoal in the medical use. Both in vitro and in vivo experiments showed the charcoal also adsorbed amino acids and bilirubin etc. as well as other charcoal. Blood cell deformation and platelet loss with the charcoal were less than those with the uncoated charcoal.
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  • Studies on hemoperfusion with the acetylated chitin coated XAD-4 (HNC-X)
    -changes in amino acids-
    M. MATSUSHITA, T. KAWAMATA, T. TSUBURAYA, A. KAKITA, I. KOSHINO, T. KO ...
    1982 Volume 11 Issue 6 Pages 937-940
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.937
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    The adsorbability for amino acid of the newly diviced corted XAD-4 (coated by Acetylated chitin-HNC-X) was evaluated in vivo and in vitro. The adsorbability of TAA, EAA, NEAR was 16%, 22% and 11% respectively. HNC-X was applied to the obstructive jaundice in dog. After 2 hours perfusion, the concentration of Arg, Glu, Asp were extremely reduced to 32%, 43%, and 50%. It was concluded that the removal rate of each amino acids were different in in vivo and in vitro. These amino acids removed from the blood in high removal rate were all belonging to the members of Krebs-Henseleit cycle.
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  • Studies of hybrid artificial Liver
    -Evaluation of experimental metabolic support device using isolated hepatocytes-
    S. KASAI, I. OIKAWA, H. ASAKAWA, H. YAMAGUCHI, T. YAMAOTO, M. SAWA, M. ...
    1982 Volume 11 Issue 6 Pages 941-944
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.941
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    A metabolic support device was made on an experimental basis. PMMa hollow fibers were soaked into the hepatocytes suspension to exchange metabolic substances. In-vitro perfusion test and animal experiments were performed. In in-vitro perfusion test, ammonia concentration decreased remarkably and Urea-N and glucose concentrations showed an slight increase. In animal experiments, ammonia concnetration loaded intravenously showed a decrease during an application of the device. These results support the possiblity of developing a hybrid artificial liver with isolated hepatocytes.
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  • Studies for Patients with hepatic failure treated by polyacrylonitrile membrane hemodialysis (PAN-HD)
    K. OUCHI, K. KOYAMA, Y. TAKAGI, Y. ASANUMA, Y. IMAOKA, T. SATO
    1982 Volume 11 Issue 6 Pages 945-948
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.945
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    The effect of 4-hr PAN HD on clinical course and biochemical alternations was investigated in 7 patients with hepatic coma. Although 2 patients partially regained consciousness, all subsequently died. The removal of aromatic (AAA) and branched-chain amino acids (BCAA) during a 4-hr treatment were correlated to pretreatment plasma concentration of these amino acids. Hence each hemodialysis was associated with a reduction of AAA concentration but markedly elevated AAA was achieved by interrupting hemodialysis after treatment. Despite “normalization” of plasma amino acid profiles was tended to be achieved by HD, its effect was transient.
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  • Reaction kinetic studies of a hybrid type artificial liver utilizing isolated hepatocytes
    H. KUSANO, G. WADA, N. OHASHIMA
    1982 Volume 11 Issue 6 Pages 949-952
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.949
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    Theoretical and experimental evaluations of the performance of a newly-designed hepatic assist device utilizing isolated hepatocytes were made based on the reaction kinetic analysis. Optimal conditions of hepatocyte culture in terms of hepatocyte viability and a metabolic function represented by a metabolizing function of ammonia were determined by batch culture experiments using isolated hepatocytes of the rat. Results of in vitro perfusion experiments were well correlated with the theoretically calculated performances. Simulation studies related to the design problems of a full-scale device were also made on the basis of a three compartment mass transfer model.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 953
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.953
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  • Control of the conversion of fibrinogen to fibrin by synthetic polymer
    M. SUGAO, N. TOMINAGA, Y. ITOH, S. KASAI, T. AKAIKE
    1982 Volume 11 Issue 6 Pages 954-957
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.954
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    We investigated the participation of synthetic polymer in the process of fibrinogen to fibrin conversion by using “ Modified microsphere column method ” and “ Circular dichroism and ultraviolet spectroscopy method ”. It was found that the process of fibrin formation, which play an important role for designing non-thrombogenic materials, could be controled by some synthetic polymers.
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  • NEW MATERIALS ENHANCING LOCAL ACCUMULATION OF FIBRIN
    A. SUGITACHI, I. SAKAMOTO, K. TAKAGI
    1982 Volume 11 Issue 6 Pages 958-961
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.958
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    A blood clotting factor, FactorXIII and thrombin were immobilized on absorbable gelatin sponge and on suture materials, using our newly devised technique in hopes of promoting wound healing. The extent of fibrin formation was both experimentally and clinically studied. The immobilized materials proved to enhance local accumulation of insoluble fibrin and to promote wound healing.
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  • Temporal portasystemic bypass with the use of the heparinized hydrophilic catheter
    A. NAKAO, M. HORISAWA, M. SUENAGA, T. YAMAMOTO, T. KONDO, S. KAWASE, S ...
    1982 Volume 11 Issue 6 Pages 962-965
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.962
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    In five mongrel dogs, dynamic changes of blood coagulation and fibrinolytic activity after acute obstruction of the portal vein (Group I) were investigated. The heparinized hydrophilic catheter (Toray, H-RSD) was manufactured, with which portal vein was bypassed between the femoral vein in five other dogs immediately after portal vein obstruction (PVO) (Group II), and blood coagulation and fibrinolytic activity were compared with Group I. In Group I, acceleration of both intrinsic and extrinsic coagulation occured in portal blood and apparent DIC occured in portal blood ten minutes after PVO. All dogs of Group I died within average 105 minutes after PVO. On the other hand, all dogs of Group II survived for more than four hours in good condition, and no significant changes of blood coagulation and fibrinolytic activity were observed. On internal surface of the catheter, no thrombotic formation was noted. With the use of bypass procedure by this catheter, portal vein shut-down is performed safely for fairly long period during operation. Indication of this catheter is recommended broadly in hepatobiliary and pancreatic surgery.
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  • A new method to give an ant ithrombogenicity to biological materials
    Y. NOISHIKI, T. MIYATA
    1982 Volume 11 Issue 6 Pages 966-968
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.966
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    A new method to give an ant ithrombogenicity to biological materials was developed. The method is as follows. A biological material such as a collagenous material was dipped into a solution of protamin sulphate The protamin adsorbed to collagen was crosslinked to the material by glutaraldehyde. Then, the protamin crosslinked material was dipped into a heparin solution (pH2.0). By this procedure, the heparin is sonically bound to the material. The amount and the distribution of the bound heparin can be controlled by changing the protamin fixation to the material. This method is expected to be used as an antithrombogenic method of artificial organs, and as a production method of anti adhesive membrane.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 969
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.969
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  • [title in Japanese]
    Y. MORI, S. NAGAOKA, H. TAKIUCHI, H. TANZAWA, S. NISHIUMI
    1982 Volume 11 Issue 6 Pages 971-974
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.971
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    Interaction between polymers with poly (ethylene oxide) (PEO) chains and blood components. The adsorption of the blood constituents onto the surface of the polymers with the various chain lengths of PEO has been measured using A-V shunt method in rabbits. It was found that deposition of the blood elements significantly decreased with the increase in the PEO chain length.
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  • Study on materials for hybrid artificial organs
    N. TOMINAGA, S. NISHIZAWA, M. SUGAO, T. AKAIKE
    1982 Volume 11 Issue 6 Pages 975-978
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.975
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    We examined adhesion and growth of cell on various materials coated fibrin. It was found that the response of cells on fibrin-coated polystyrene and glass surfaces varied respectively. It was suggested that difference of material structures changes fine structures of fibrin, resulting in different features of cellular response.
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  • Adhesion Control of B and T Lymphocytes by Polymeric Materials Having Synthetic Polypeptide Segments
    M. MAEDA, M. KIMURA, S. INOUE, K. KATAOKA, T. OKANO, Y. SAKURAI
    1982 Volume 11 Issue 6 Pages 979-982
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.979
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    Our newly synthesized polystyrene-polypeptide graft copolymers was found to have the ability to differentiate the subpopulation of rat mesenteric lymph-node lymphocytes, B cell from T cell, in the absence of serum protein (e. g. FCS). The selectivity was revealed to depend on the high order structure of polypeptide segment and on the micro-domain structure of graft copolymer surface.
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  • Artificial bone of alumina ceramics---Biological response in the costal cartilage
    H. KATO, T. NAKAMURA, H. MIZUNO, S. MATSUNOBE, K. TAMURA, S. WATANABE, ...
    1982 Volume 11 Issue 6 Pages 983-986
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.983
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    Polycrystalline ceramics was found to be an excellent biomaterial in its biological affinity to the cartilage tissue as well as to the bone. Namely, cartilage healed rapidly and correctly without inflammation and foreign-body reaction in 8 weeks, and matured well with acidmucopolysaccharide-rich tissue. It adhered to the ceramics four or eight times as strongly as to the steel. Scanning electron microscope showed cartilage tissue remained to adhere onto the surface of ceramics, which was pulled out, but not onto the steel.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 987
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.987
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  • Bioadaptability of wearable-type artificial endocrine pancreas was examined
    Long-term bioadaptability of the wearable-type artificial endocrine pancreas
    M. SHICHIRI, R. KAWAMORI, Y. GORIYA, Y. YAMASAKI, N. HAKUI, T. YAGI, T ...
    1982 Volume 11 Issue 6 Pages 988-991
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.988
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    Leakage of glucose oxidase was not detected at all with a stable output of sensor to glucose as long as 3 days even if it was kept in sc tissue. Change in membrane surface of sensor was minimum by scanning electron microscopy. These data indicated the long-term bioadaptability of the wearable-type artificial endocrine pancreas.
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  • Artificial pancreas--Improvement of membranes for glucose sensor--
    S. IKEDA, Y. SAWADA, K. MINO, M. ISHIDA, K. ITO, K. ICHIKAWA, T. YUKAW ...
    1982 Volume 11 Issue 6 Pages 992-995
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.992
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    In order to improve the response properties and the life of the glucose sensor, several new types of semipermeable membranes (SM) and immobilized enzyme membranes (IEM) prepared have been tested in vitro. The following results were obtained. i) The linearity of calibration curve of the sensor highly depends on the semipermeability of SM and the activity of IEM. ii) SM of acetylcellulose is able to control the semipermeability according to the preparation condition. ii) IEM using AMP CUNO's nylon filter has a higher activity. The sensor constructed with these membranes has better and faster response to BGL and longer life.
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  • HYBRID ARTIFICIAL PANCREAS
    -ATTACHMENT TO PORTAL CIRCULATION-
    H. NAKANO, M. SEGAWA, K. NAKAGAWA, Y. NAKAJIMA, T. SHIRATORI
    1982 Volume 11 Issue 6 Pages 996-999
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.996
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    The hybrid artificial pancreas attached to the systemic circulation, containing 10000 xenogeneic hamster islets, restored normoglycemia in 4 out of 6 totally pancreatectomized dogs. However, none of 4 dogs achieved to normoglycemia, when this device was attached to the portal circulation. The device attached to the portal circulation, containing 14000 islets, was able to restore normoglycemia in 4 out of 5 dogs. Plasma insulin levels after attachment to the systemic circulation were higher than those to the portal circulation. While, there was no significant difference in pattern of plasma glucose disposal.
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  • Microencapsulation of Minced Pancreas
    Y. ARAKI, S. KAJIYAMA, Yoshio NAKAMURA, M. KONDO
    1982 Volume 11 Issue 6 Pages 1000-1003
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1000
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    After mechanical mincing, rat pancreas was dispersed by collagenase and DNAase digestive solution.This dispersed pancreas was encapsulated by a semipermeable membrane composed of alginate, poly-L-lysine and polyethyleneimine, and then cultured for 49 days. A significant insulin secretion from the encapsulated pancreatic tissue was observed in response to the change of glucose concentration in the culture medium during this culture study. During the experiment perifusion test on the encapsulated minced pancreatic tissue was performed using dual perifusion system. Substantial increase of insulin secretion in response to high concentration of glucose, and rapid, significant decrease of insulin secretion in response to low concentration or glucose was observed. No significant difference in the responsiveness of insulin release was observed between the encapsulated and unencapsulated pancreatic tissue. These results show that microencapsulated minced pancreas without specific isolation of islets would be useful for circumventing the rejection problem in the transplantation of pancreatic tissue for amelioration of diabetes.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 1004
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1004
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  • A study of atrial endocardial signals
    M. MURASE, T. ABE, T. WASHIZU, M. TANAKA, M. KAWAMURA, E. TAKEUCHI, R. ...
    1982 Volume 11 Issue 6 Pages 1005-1008
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1005
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    Fifty-seven atrial signals in 47 cases were studied. Amplitude of the endocardial signal of sick sinus syndrome (SSS, 2.1±1.0mV, mean±SD, n=28) is significantly lower than that of atrioventricular block (AVB, 4.0±1.1mV, n=12, p<0.001). The total p-wave voltage of leads I, II, and III of ECG is lower in SSS (0.30±0.11mv, n=35) than in AVE (0.46±0.11mV n=11) significantly (p<0.001). And the total p-wave voltage shows relatively good correlation to the amplitude of atrial endocardial signal (Y=0.22+0.05X, r=0.532). Amplitude of intraatrial signal may be suspected preoperatively.
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  • Follow up of lithium powered pacemaker patients and problems at pacemaker exchange
    H. KUME, M. MATSUI, K. MARUYAMA, S. SUZUKI, Y. SUGITA, T. KOZUKUE, H. ...
    1982 Volume 11 Issue 6 Pages 1009-1012
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1009
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    Since 1976 we have followed 148 Lithium powered pacemaker up. Two cases were removed because of the pacemaker failure. The lead impedance have a strong influence on the service life of PM. And the lead impedance calculated by the pacergram was closely corresponding with the lead impedance obtained by telemetry.
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  • Susceptibility of unipola demand pacemaker to electromagnetic interference
    H. AIDA, K. WATANABE, Y. ANZAI, S. SAKAMOTO, S. HAYASE, M. NAKAJIMA, H ...
    1982 Volume 11 Issue 6 Pages 1013-1016
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1013
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    The purpose of this study is to determine if the direction of electrical stimuli affect the susceptibility of unipolar demand pacemaker to EMI. EMI is liable to occur when TENS electrodes are placed in pallalel direction with pacemaker electrodes vector. Myopotentials followed TENS stimuli also seem to be a factor of EMI occurrence.
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  • Clinical evaluation to the parameters of multiprogrannable pulse generator
    A. NAKAMURA, Y. KANKI, T. IWAMOTO, M. KADOWAKI, S. SATOH, K. KITAURA, ...
    1982 Volume 11 Issue 6 Pages 1017-1020
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1017
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    One hundred thirty five multiprogramrnable pulse generators were implanted and studied on the programmable parameters in clinical use. The rate programmability was available for the purpose of hemodyna rLc improvement, examination, maintenance of A-V synchrony and so on. In AAI mode, the output and sensitivity programmability were used for the pacing or sensing failure, and the result was satisfactory. But these parameters were in need of further range, because of the exit block or under sensing in atrial pacing. The hysteresis programmability was available.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 1021
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1021
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  • Studies of the artificial blood (Fluosol-DA)
    H. INOUE, K. HANEDA, J. MIURA, M. KANNO, A. USUBA, F. IWAYA, S. HOSHIN ...
    1982 Volume 11 Issue 6 Pages 1022-1025
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1022
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    So-called artificial blood (Perfluorochemical emulsion, Fluosol-DA®) is used as oxygen carrying substitutes in acute massive hemorrhagic patients, priming solution for extracorporeal circulation, and perfusate for intracadaveric organ perfusion for renal transplantation. Especially Fluosol-DA is useful in acute massive hemorrhagic patients who have rare blood type or refuse bloodtransfusion.
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  • Microvascular hemodynamic changes accompanying intravenous injection of artificial blood substitute (perfluorochemical emulsions)
    Effect of emulsifier
    X.-X. ZHENG, M. SATO, N. OHSHIMA
    1982 Volume 11 Issue 6 Pages 1026-1029
    Published: December 15, 1982
    Released on J-STAGE: December 02, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1026
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    Microhemodynamic changes accompanying the intravenous injection of perfluorochemical emulsion (Fluosol-43, FC-43) as well as an emulsifier contained in that emulsion, i. e. Pluronic F-68, PF-68, were studied in the rat mesentery by means of an intravital television microscope. Experimental results revealed that a remarkable increase in capillary blood flow and an augmented leucocyte sticking along venular wall was induced in either case of the intravenous injection of FC-43 and PF-68, which suggest that the emulsifier plays a primary role in determining the microvascular behavior of the intravascularly infected PFC emulsion.
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  • Experimental Studies on Renal Preservation with Perfluorochemicals and Silicagel plasma
    Y. ENDO, K. HANEDA, H. INOUE, J. MIURA, Y. TERANISHI, O. KONNO, F. IWA ...
    1982 Volume 11 Issue 6 Pages 1030-1033
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1030
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    Comparing Perfluorochemicals (PFCs) with Silicagel Fraction Plasma on renal preservation of adult mongrel dogs under hypothermia, PFCs showed less elevation of renovascular resistance. We conculded that PFCs is useful on renal preservation for the Cadavaric renal transplantation.
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  • Nonoperative closure of ventricular septal rupture -- a newly developed balloon catheter method
    T. HATTA, T. SHIDA, M. MIYASHITA, K. NAKAMURA
    1982 Volume 11 Issue 6 Pages 1034-1038
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1034
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    This experimental work was undertaken to develop a new method to close the ventricular septal rupture (VSR) tempolarily. The hemodynamic effect of the VSR produced by a specially designed septotome was evaluated in 17 mongrel dogs. When the size of the VSR was more than 9mm in diameter, all of the dogs died in either frank acute heart failure or severe arrhythmia. If the size of VSR was less than 9mm in diameter, all of the dogs survived without sequelae. A specially curved catheter-sheath was developed to faciliate easy insertion of the balloon catheter into the VSR. A modified Fogarty venous occlusion catheter (8F) was introduced via superior vena cava into the left venticle through this balloon catheter method in 9 dogs and succeeded in 7 dogs. In conclusion, this method seems to be very useful and attractive but further modification will be neccessary before its clinical use.
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  • The application of a 2-lumen, single balloon catheter for the occlusion hepatic venography
    Y. INAGAKI, Y. YAMASHITA, H. KANO, H. KISHIMOTO, H. ISHIGURE, T. IKEDA ...
    1982 Volume 11 Issue 6 Pages 1039-1044
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1039
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    2-lumen, single balloon catheter (2L-SBC) was designed to measure portal venous pressure (PVP) and to visualize all the hepatic veins The shaft and balloon parts are made of silicone rubber. But as the friction resistance between silicone rubber and guide wire is great, polyethylene tube was inserted into the inner side of silicone to reduce this resistance. Making use of the thermo-plasticity of polyethylene, some length of extreme part can be bent and its bent part of 2L-SBC can be hooked easily on the hepatic veins. It's possible to measure the PVP and occlude even the widest hepatic vein completely by this catheter. This method allows us the visualization of all the hepatic veins clearly and safely.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 1045
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1045
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  • High Na dialysis control system with ICU dialysis monitor
    K. YAGATA, H. KAWAGUCHI, T. UCHIMA, T. WATANABE, Y. YAMADA, T. YANAGIS ...
    1982 Volume 11 Issue 6 Pages 1046-1049
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1046
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    The optimum dialysate Na concentration in a high Na dialysis system can be determined theoretically by the compartment model of solute and water removal. But, as the Na concentration is affected by the individual difference, the food intake during a dialysis, and by the psycological status of patients, it is thought neccessary to make a feedback of biological informations of a patient to the system.
    A feedforward-feedback controled high Na dialysis was developed: the Na concentration was determined by the filtration rate as a feedforward control, and by the blood pressure as a feedback control. The blood pressure was monitord with ICU dialysis system which is conected to the high Na dialysis system. Thus, the blood pressure was maintained within a nomal limit.
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  • Determination of the optimum Na+ conc. in dialysate
    K. OZAWA, I. ITAGAKI, M. MINESHIMA, K. SAKAI, M. NANBU, T. SAKAI, J. H ...
    1982 Volume 11 Issue 6 Pages 1050-1053
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1050
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    Three-compartment model was proposed to explain the water shift within a body, and the following results were obtained. (1) Water shift among these compartments depends on the total osmolarity of dialysate. (2) After dialysis the water shift is completed in about 30 minutes with a slight amount of water. (3) Theoretical results agree well with clinical data. If the above model is simplyfied by using dimens ionless equations, the optimum Na+ concentration of dialysate may be easily determined by the removed amount of Na+.
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  • pH Change of body Water in Hemodialysis using Acetate or Bicarbonate
    H. TANAKA, M. MINESHIMA, K. SAKAI, S. FUJISHIMA, Y. NISHIMOTO, H. NAKA ...
    1982 Volume 11 Issue 6 Pages 1054-1057
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1054
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    The dialysate, which contains Acetate and or Bicarbonate, are widely used to keep the blood pH whith in ordinary level. Its concentration has been determined only by the experiences of doctors and tecnitians, and is not always fit for patients and machines. In this report, the pool model which simulates the time plofiles of Acetate, Bicarbonate, CO2 gas and pH in blood was devised to analyse. The dialysate, which contains the mixture of Acetate and Bicarbonate, should be used in dialysis, where dialys ate composition is determined according to each patients ability of Acetate metabolisum.
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  • Difference in hemodynamic changes between acetate and bicarbonate hemodialysis
    T. KAWAMURA, T. ANNO, H. UEMATSU, T. SHIMIZU, H. OISHI, T. YAMAMOTO, S ...
    1982 Volume 11 Issue 6 Pages 1058-1060
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1058
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    Hemodynamic effects of isovolumetric hemodialysis (HD) were studied in 6 patients using two different dialysates; acetate and bicarbonate. For each HD, hemodynamic parameters were measured hourly by the use of Swan-Ganz thermodilution catheter. During acetate HD, significant reduction in both systemic vascular resistance (SVR) and mean arterial pressure (AP) was observed. Cardiac output (CO) was increased mildly with the resultant reduction in pulmonary capillary wedge pressure (PCWP). During bicarbonate HD, however, these parameters showed little changes. The effects of catecholamines (noradrenaline (NA) and dopamine (DOP)) on the hemodynamic changes during acetate HD were also investigated. NA infused at the rate of 0.20-0.24μg/kg/min increased SVR toward control level and restored AP. CO, PCWP, and HR were affected insignificantly by the intervention. For the SVR and AP restoration equivalent to those with NA, required DOP dose was 15-20μg/kg/min which produced a significant increase in HR. We conclude that: (1) for the patients who show cardiovascular instability during HD, bicarbonate HD appears more feasible than acetate HD; (2) fall in SVR and AP during acetate HD could be treated more effectively with NA than with DOP.
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  • Development of a part of WASEDA automatic dialysis controller (WADIC)
    T. IGARASHI, S. TAKESAWA, M. MINESHIMA, K. SAKAI, T. WADA, H. NNKANISH ...
    1982 Volume 11 Issue 6 Pages 1061-1064
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1061
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    Effectiveness of conventional hemodialysis (HD) is not clear during HD treatment, so that the control of dialysis therapy depends on the experience of doctors and technical experts. A dialysis watching system, then, needs to be developed in order to a patient on HD during the treatment. This system can obtain the information about BUN concentration without collecting blood.
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  • Elimination of low molecular weight proteins from CAPD treatment
    T.G. CHUNG, I. KANAZAWA, O. ODA, A. SAITO, K. OHTA
    1982 Volume 11 Issue 6 Pages 1065-1068
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1065
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    Dialysate from CAPD treatment was analysed by SDS-polyacrylamide gel electrophoresis, irrinunodiffusion method and high performance liquid chromatography. Thirteen kinds of low molecular weight proteins were determined. Reducing the accumulation of low molecular protein might be effective in the treatment of uremic symptoms.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 1069
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1069
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  • The efficacies of gas transfer exchange performance of “Interpulse” membrane oxygenator were studies and following results were obtained
    N. AONO, M. UMEZU, Y. TAENAKA, T. TANAKA, H. TAKANO, T. AKUTSU, Y. KIT ...
    1982 Volume 11 Issue 6 Pages 1070-1074
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1070
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    1. The increse of oxygen-blood flow ratio (V/Q) was corresponded well with the increase of both oxygen and carbon dioxide transfer rates as well. These rations were stabilized at the level of 0.5 and 3.0, respectively.
    2. The increment of pulse rate of this device yielded with the increase of both of oxygen and carbon dioxide transfer rates. We conclude that the performance of this new type membrane oxygenator has certain advantages over to the conventional type, the optimum control index for clinical use appears to be established.
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  • Developement of a new membrane oxygenator (Microporous Polysulfone Hollow Fiber)
    T. ITAOKA, H. KAIZUKA, J. KEI, H. NAKAJIMA, T. KAWAMURA, M. YOKOYAMA, ...
    1982 Volume 11 Issue 6 Pages 1075-1078
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1075
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    We developed a new membrane oxygenator (PS-AL) which consists of microporous polysulfone hollow fibers, 205μ in inner diameter and 293μ in outer diameter.
    The surface area available for gas exchange was 1.1m2. Gas exchange performance was obtained in vitro and in animal experimental studies. Oxygen gas transfer rate was 95.6±3.83mL/min/m2 and carbon dioxide gas transfer rate was 63.7mL/min/m2 (QB 1500mL/min, Gas Flow Ratio 1.0).
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  • HYDRODYNANIC STUDY ON BED-SIDE TYPE PULSATILE EXTRACORPOREAL CIRCULATION SYSTEM
    T. SHIROYAMA, T. AKAMATU, H. FUKUMASU, S. YUASA
    1982 Volume 11 Issue 6 Pages 1079-1082
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1079
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    A closed type pulsatile extracorporeal circuit has been developed instead of conventional perfusion by a roller pump. This is composed of alternate pump ing double chambers (right heart), a membrane oxygenator, a heat exchanger and a pulsatile pumping chamber (left heart). The possible short tubing aims at the small priming volume. Hydrodynamic charactaristics of each element and of the whole system combined with a MOCK circulation were investigated. Bypassing between the right reservoir and the left reservoir proved to reduce the interaction between the right heart system and the left. In the right heart system, the regurgitation by heart valves and the excess rigidity of the hollow fiber oxygenator turn out to be improved.
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  • A new artificial heart-lung machine with automatic recording system
    T. OKADA, A. GOMI, Y. OKAMURA, H. MASUDA, J. HATTORI
    1982 Volume 11 Issue 6 Pages 1083-1087
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1083
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    Many attempts have been made to operate the artificial heart-lung machine under automatic control. We took the first step only to record data automatically. We developed a new artificial heart-lung machine which has a micro-computer and has units of topical cooling and perfusion of cardioplegia for myocardial protection. The following data from AHL machine and a patient were recorded every 5 minutes automatically. The data were flow rate, arterial and venous pressure, and temperature of artery, vein, myocardium and rectum. In addition, other data such as drug infusion were input to computer voluntarily. The results helped not only to record more precisely, but also to calculate the total balance of water and blood immediately. We believe, these precise recordings will be effective to determine the optimum criteria of extracorporeal circulation, which is useful to promote the automation.
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 11 Issue 6 Pages 1088
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1088
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  • Clinical Experiences of Interpulse Membrane Oxygenator for Open Cardiac Surgery
    M. MATSUI, Y. SUGITA, K. MORITA, K. SUZUKI, T. MIZUNO, T. ARAI
    1982 Volume 11 Issue 6 Pages 1089-1092
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1089
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    The Interpulse membrane oxygenator has been constructed useing 0.3 micron microporous membrane. It has the wide seven blood channels and 0.8 M2 small gas exchange area. A to and fro pulse is applied to the blood through the oxygenator, creating secondary flow in the blood channels. PaO2, PaCO2 and other gas data have been controled easily within the appropriate range. Hematological data have been changed in the same manner as the data of other membrane oxygenator. During total cardio-pulmonary bypass, the radial art. pressure has been indicated the pulsatile wave.
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  • Clinical use of a new membrane exyganator
    H. SHINOHARA, H. TANOI, T. OKAZAKI, K. OMORI, Y. NAKAOKA, Y. ISHII, H. ...
    1982 Volume 11 Issue 6 Pages 1093-1096
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1093
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    We developed a silicone hollow fiber oxygenator. The surface area available for gas transfer was 5M2 and the priming volume was 450ml. S. H. O. was tested in animal experiments. Experimental study showed satisfactory results. S. H. O. were used in 42 cases including 5 congenital, 21 ischemic and 16 valvular diseases. Mean perfusion time was 138min. PaO2 was maintained from 300 to 400mmHg with the control of oxygen concentration. PaCO2 was 32±7.4mmHg during perfusion. Plasma free hemoglobin was increased up to 24mg/dl/hr. In conclusion, S. H. O. was demonstrated to have excellent capacity for gas exchang with minimal hemolysis in 42 cases undergoing open heart surgery.
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  • [title in Japanese]
    J. NINOMIYA, N. YAMATE, M. OCHI, T. MIZUTANI, T. WAKABAYASHI, K. KOBAY ...
    1982 Volume 11 Issue 6 Pages 1097-1100
    Published: December 15, 1982
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.11.1097
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    Study of extracorporeal circulation of 10 cardiac patients with diabetes or borderline type was examined to measure blood glucose, urinary glucose, and insulin levels regularly during and after extracorporeal circulation. During the extracorporeal circulation, blood and urinary glucose levels of these 10 patients were significantly higher than the glucose levels of control group (P<0.001) in spite of almost same depressed levels of insulin between these patients and control group. After the extracorporeal circulation, blood and urinary glucose levels of these borderline and diabetic patients had a tendency of decreasing toward normal level as well as these levels of control group except that high glucose levels in three patients with diabetes were continued.
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