To characterize the mechanisms of induction and regulation of the cell population involved in granuloma formation around eggs of
Schistosoma japonicum, we utilized a simple method of in vitro experiments. Lyt1
+2
- T cells were essential for in vitro responses to the intact
S. japonicum eggs, which were assumed to be comparable to in vivo granulomatous responses. T-cell responses seemed to be macrophage-dependent, and responding T cells produced IL-2-like activities in the culture supernatant. Sera taken from chronically infected mice acted as regulatory factors to these T-cell responses as was the case in in vivo granuloma formation. The method used here was simple and highly informative for the studies on pathogenesis of schistosomiasis japonica.
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