In the preceding paper (Takasaka
et al., 1964) which dealt with the epidemiology of natural infection of
Shigella bacilli in cynomolgus monkeys, the authors have stated that
Shigella bacilli may have some causative role in the development of dysentery in monkeys. If this disease can be reproduced in monkeys experimentally with success by means of oral administration of the bacilli, it will aid probably in clarifying the etiology, pathogenesis, treatment and prevention of dysentery in monkeys. Moreover, it will be available as an experimental model to elucidate a number of unsolved problems relating to human bacillary dysentery, because the production of dysentery of essentially the same type as human bacillary dysentery is impossible in ordinary laboratory animals — such as rabbits, rats, mice, guinea pigs and dogs, etc. — by any known method of infection, and spontaneous dysentery in monkeys closely resembles human bacillary dysentery in its feature.
Although many works concerning the experimental infection in monkeys with
Shigella bacilli have been reported by Soviet investigators (Tumanian, 1956), they have not described in full detail the methods and procedures of experiments including the conditions of monkeys used as well as the results obtained. Therefore, the present authors are unable to evaluate properly their investigations.
Dack (1934) reported that a freshly isolated virulent strain of
Shigella organisms produced an infection in an isolated loops of the colon of rhesus monkeys resulting in a profuse bloody mucous discharge. However, these monkeys showed no signs of infection in the bowel except in the isolated segments of colon. Also Branham
et al. (1949) were unable to establish clear-cut infection with
Shigella dysenteriae in mulatta macaques.
In Japan, Ebira (1937) reported a study of
Shigella infection using monkeys, but his study may not be strictly criticized or appreciated since it was done when the knowledge of the monkey itself used as an experimental animal had not been so sufficient in Japan. Recently, Hayashi and Iwahara (1962, 1964a, b, c) published papers in which they concluded all monkeys used had developed clinical symptoms and pathological changes of dysentery. Their findings, however, evidently differ from those of spontaneous dysentery in monkeys which the present authors usually observe at NIH; the former showed severe systemic reactions while the latter had not such reactions but limited changes in the large intestine. In the present study, the authors tried to produce dysentery in cynomolgus monkeys under certain experimental conditions that were controlled as sufficiently as possible on the basis of the present knowledge of monkeys used for medical and biological purposes. Pathological findings of this work will be published in the subsequent paper (Ogawa
et al., 1964) .
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