For investigation of allergens in nasal allergy, there are several methods; skin test, nasal provocation test and measurement of specific IgE antibodies. Skin tests or nasal provocation tests sometimes cause trouble to the clinicians or patients, because the conditions can affect the results, or the tests may make allergic symptoms worse. A simpler examination is desired. The measurement system of IgE antibodies is expected to be a usuful method to approximate diagnosis, because we only have to take one blood sample from the patient.
Many systems are developed to measure IgE antibodies. Indications are that the CAP system is one reliable way and AlaSTAT, an enzyme-immunoassay method developed by Diagnostic Products Corporation in recent years, may be another.
In this study, we measured the three IgE antibodies by AlaSTAT and CAP system, and compared the results with that of skin tests or nasal provocation tests. The three IgE antibodies were house dust (HD1), Dermatophagoides pteronyssinus (D1) and Dermatophagoides farinae (D2) which were major allergens of perennial nasal allergy.
These methods obtained negative results in normal donors.
In patients with perennial nasal allergy, the resurts of AlaSTAT were as follows;
The positive rates were 85.7% on HD1, 80.0% on D1 and 85.7% on D2.
The sensitivity, specificity and correspondence rate to skin test were 87.9%, 50%, 85.7% on HD1 and 96.4%, 57.0%, 88.6% on D2, respectively.
The sensitivity and correspondence rate to nasal provocation test were 87.5%, and 74.1% on HD1, respectively.
At many points, there were excellent correlations with CAP system.
These results indicate that AlaSTAT stands, in comparison with CAP system, as a reliable method of clinical diagnosis for perennial nasal allergy.
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