巻号一覧
59 巻, 1 号
選択された号の論文の13件中1～13を表示しています
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長澤 紘一, 中原 保裕1992 年 59 巻 1 号 p. 2-8
発行日: 1992/02/15
公開日: 2010/10/14
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経ロブドウ糖負荷試験による検討角田 守, 大木 由加志, 峰田 喬臣, 手代木 正1992 年 59 巻 1 号 p. 9-20
発行日: 1992/02/15
公開日: 2010/10/14
ジャーナル フリーWe analyzed O-GTT obtained from 375 children (group A; 7-11 years old) and adolescents (group B; 12-16 years old), including 96 normal non-obese cases, 266 simple obese cases (172 with normal O-GTT, 79 with border line type O-GTT and 15 with diabetic type O-GTT), 8 obese NIDDM cases and 5 non-obese NIDDM cases.
The results were as follows;
1) The levels of IΣCPR (in terms of total sum of the values measured at 0, 30, 60, 120 and 180 minutes on O-GTT) in the obese children and adolescents were only 1.5 and 1.2 times as high as in the control group. The levels of ΣCPR/ΣIRI molar ratio in the control group were 2.0 and 2.3 times as high as in the obese children and adolescents. These data suggest that hyperinsulinemia in the obese children and adolescents is caused mainly by decreased hepatic insulin extraction rather than by increased insulin secretion.
2) In the non-obese NIDDM adolescents, the levels of ΣCPR decreased to about 3/4 of those in the control group; in contrast, the ΣCPR/ΣIRI molar ratio increased. Therefore, it seems that there is increased hepatic insulin extraction as well as decreased insulin secretion in the non-obese NIDDM adolescents.
3) In the obese NIDDM adolescents, the levels of. CPR were nearly the same as in the control group and the. ΣCPR/ΣIRI molar ratios were slightly lower as the disease state of NIDDM counterbalanced obesity.抄録全体を表示PDF形式でダウンロード (2094K) -
A possible role of lipid peroxidationToshiaki Shirota, Koji Sasajima1992 年 59 巻 1 号 p. 21-28
発行日: 1992/02/15
公開日: 2010/10/14
ジャーナル フリーPostoperative hyperbilirubinemia was investigated in 18 patients who underwent a singlestaged esophagectomy and reconstruction. The totalserum bilirubin (TSB) concentration increased progressively after surgery without any evidence of sepsis and reached a peak on day 5 from 0.5 0.1 to 2.4 0.4 mg/dl (p<0.01), and then decreased by day 14. The TSB concentration rose above 2.5 mg/dl on days 5 or 7 in 8 patients (44%). Alkaline phosphatase and SGOT showed a mild increase during the postoperative period. The increase in the serum lipid peroxide (LPO) concentration, which was measured as malondialdehyde, after surgery correlated closely with the change in the TSB concentration. The LPO concentration was significantly elevated only in the patients with postoperative hyperbilirubinemia, and showed a correlation with the TSB concentration (r=0.81, p<0.01). The level of serum alpha-tocopherol decreased after surgery, but did not differ between the patients with or without postoperative hyperbilirubinemia.
These results suggest that lipid peroxidation reactions play a role in the development of hyperbilirubinemia after esophagectomy, which may be due to benign intrahepatic cholestasis.抄録全体を表示PDF形式でダウンロード (1097K) -
青木 文1992 年 59 巻 1 号 p. 29-40
発行日: 1992/02/15
公開日: 2010/10/14
ジャーナル フリーUsing a 0.2 T permanent MR imaging system, the gradual changes of signal intensity after intravenous injection of Ferrite suspension were studied in liver of normal rabbits and those with intrahepatic VX2 tumor.
After injection of Ferrite suspension, decreased signal intensities of liver were observed on both Ti and T2 weighted images. The decrease on T2 weighted images was more remarkable than that on the Ti weighted image.
The image with 8 mg/kg (50 μmol/kg) dose of Ferrite suspension showed significant changes of signal intensity, while, the image with 24 mg/kg (150 μmol/kg) dose was hardly evaluated because of inducing intense artifacts.
The decrease of signal intensity in liver was observed immediately after the injection and was lowest after 1 hour. After 48 hours, the signal intensity began to increase. However, a slight loss of signal intensity was visualized even after 4 weeks.
A clear MRI of the intrahepatic tumor following injection of Ferrite suspension was acquired especially on T2 weighted image in comparison with MRI after Gd-DTPA administration. In addition, MRI using Ferrite suspension could detect the small intrahepatic tumors which had been unable to be visualized by plain CT or enhanced CT. It is of benefit, furthermore, that Ferrite suspension could be an useful tracer for observing the intrahepatic tumor growth by a first single injection.
Histologically, Ferrite particles were accumulated in reticuloendothelial system of liver whereas no accumulated in intrahepatic tumor was verified. The particles produced changes in local magnetic field resulting that signal intensity of liver showed decrease on the image. Subsequently, relatively negative contrast enhancement of liver was displayed.
As a result of the present investigation, the MR imaging following injection of Ferrite suspension was found to be useful for detection of intrahepatic tumors, particulary of metastatic tumors which were isointense or hypovascular to the surrounding tissue of liver. No evidence of acute toxicity by Ferrite administration has been noticed.抄録全体を表示PDF形式でダウンロード (13297K) -
山本 彰, 福田 悠1992 年 59 巻 1 号 p. 41-50
発行日: 1992/02/15
公開日: 2010/10/14
ジャーナル フリーThe mechanism of the formation of alveolar pores (Kohn's pores) in neonatal male rabbits was studied by scanning electron microscopy and scanning electron microscopic morphometric analysis. The number of alveolar pores per alveolus was increased after birth. About 80 percent of alveolar pores had Type II alveolar epithelial cells on their edges when the rabbits were 1-day old. This percentage decreased thereafter. Circlelike intercellular junctions of Type I cells were frequently observed in or around the alveolar pores and Type II cells frequently attached to these junctions in the early neonatal stage. The alveolar pores with Type II cells which were mainly faced this side of alveolar lumen, and Type II cells which were separated from the pores tended to be found at the points where three or more Type I alveolar epithelial cells gathered in the early neonatal stage. However, alveolar pores with Type II cells which were mainly faced other side of the alveolar lumen, and alveolar pores without Type II cells tended to be found between two Type I cells. At the rims of the pore, crescent-shaped Type II cells located between circle-like intercellular junctions were frequently observed in the early neonatal stage. In conclusion. 1) One of the function of Type H alveolar epithelial cells is to form the alveolar pores. 2) Alveolar pores are formed by Type II cells which have penetrated into the alveolar wall and faced both sides of the alveolar lumina. Type II cells combine the Type I alveolar epithelial cells of both sides of the alveolar wall and make pores with circle-like intercellular junctions. 3) Type II cells, attached to circle-like intercellular junctions, move and decrease in number after the formation of alveolar pores.抄録全体を表示PDF形式でダウンロード (6557K) -
Yoichiro Yamanaka1992 年 59 巻 1 号 p. 51-61
発行日: 1992/02/15
公開日: 2010/10/14
ジャーナル フリーThe expressions of epidermal growth factors (EGF), epidermal growth factor receptors (EGFR), and the c-erbB-2 oncoprotein were immunohistochemically examined in 25 cases of human pancreatic carcinoma and epineoplastic pancreatitis and in 10 non-cancerous/noninflammatory pancreatic tissues. The positive rates of EGF, EGFR, and the c-erbB-2 oncoprotein in cancer tissues were 72%, 36%, and 28%, respectively. EGF was stained mainly in the cytoplasm and partly on the surfaces of the cancer cells. EGFR and the c-erbB-2 oncoprotein were stained mainly on the surfaces of the cancer cells and partly in the cytoplasm. The expressions of these 3 products correlated significantly with tumor invasion into the anterior and posterior areas surrounding the pancreas. In the EGF, EGFR, and c-erbB-2 positive cancer tissues, some stromal cells, that is fibroblasts and endothelial cells, were also positive. In the adjacent pancreatic tissues with inflammation, these products were noted in some ductal cells, acinar cells, fibroblasts and endothelial cells. No distinct staining was detected in non-cancerous/non-inflammatory tissues. The survival period for patients who tested positive for these three proteins was statistically shorter than for those who tested negative. These results suggest that the coexpression of EGF and EGFR and the expression of the c-erbB-2 oncoprotein are related to the existence of the invasion of human pancreatic cancer. Furthermore, an immunohistochemical examination of these three products is useful in forming a prognosis for pancreatic cancer patients.抄録全体を表示PDF形式でダウンロード (5457K) -
王 慕一, 池田 幸穂, 中沢 省三1992 年 59 巻 1 号 p. 62-65
発行日: 1992/02/15
公開日: 2010/10/14
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第1報甲状腺疾患の診断と治療清水 一雄1992 年 59 巻 1 号 p. 66-69
発行日: 1992/02/15
公開日: 2010/10/14
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山岸 嘉彦1992 年 59 巻 1 号 p. 70-74
発行日: 1992/02/15
公開日: 2010/10/14
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松本 光司, 佐藤 春明, 大塚 俊司, 山田 宣孝, 浅野 伍朗1992 年 59 巻 1 号 p. 75-80
発行日: 1992/02/15
公開日: 2010/10/14
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吉野 愼一1992 年 59 巻 1 号 p. 81-83
発行日: 1992/02/15
公開日: 2010/10/14
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1992 年 59 巻 1 号 p. 84-92
発行日: 1992/02/15
公開日: 2010/12/22
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1992 年 59 巻 1 号 p. 93-94
発行日: 1992/02/15
公開日: 2010/12/22
ジャーナル フリーPDF形式でダウンロード (330K)
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