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31 巻, 12 号
選択された号の論文の12件中1～12を表示しています
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「中赤外自由電子レーザーが拓く応用研究」特集号
特集号
レーザー解説
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粟津 邦男2003 年 31 巻 12 号 p. 791-792
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーPDF形式でダウンロード (137K) -
山崎 鉄夫2003 年 31 巻 12 号 p. 793-798
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーA review is made of the principle and recent development of free-electron lasers (FELs) with emphasis on applications in the infrared wavelength region. Technologies of FEL generation have become mature, and now, it is time to expand the application areas.抄録全体を表示PDF形式でダウンロード (1129K) -
内藤 康秀, 粟津 邦男2003 年 31 巻 12 号 p. 799-804
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーAs an emerging field of molecular biology, proteomics gives a great impact on pharmaceutics, medicine and life science. The objectives of proteomics include protein identification and quantification, profiling of expression dynamics and localization, mapping of post-translational modifications, and probing of protein-ligand interactions. Because of tremendous complexity and diversity of protein world, proteomics requires high-throughput analytical technologies, which basically consist of gel electrophoresis, in-gel digestion, mass spectrometry and bio-informatics based on genome database. There are two aspects in which mid-infrared free-electron laser (MIR-FEL) can facilitate proteomics study: being used as a desorption laser in matrix-assisted laser desorption/ionization (MALDI) and as an activation laser in infrared multi-photon dissociation (IRMPD). This commentary article describes how MIR-FEL can be of benefit to proteomics, and indicates an ideal approach utilizing MIR-FEL to the goal of proteomics.抄録全体を表示PDF形式でダウンロード (671K) -
部谷 学, 内園 岳志, 佐野 秀, 石井 克典, 岩本 由美子, 熊崎 洋晃, 鈴木-吉橋 幸子, 粟津 邦男2003 年 31 巻 12 号 p. 805-810
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーA mid-infrared Free Electron Laser (MIR-FEL) has potentials for medical application research. The MIR-FEL has great two advantages: (1) tunability and (2) double pulse structure. The Osaka MIR-FEL is tunable from 5 to 17 μm, and produces a macropulse, composed of a train of micropulses, each approximately 5 ps long and separated by 44.8 ns. (1) Since there exist main absorbers such as water, protein, and apatite in the tissue, wavelength tunability leads to a choice of the primary absorber. (2) Laser-tissue interactions are mainly determined by the power density of the laser used. Therefore the interactions can be precisely controlled by a combination of the energy density and pulse duration of the macropulse, and the repetition rate of the micropulse. Thus, the MIR-FEL can carefully optimize the laser conditions for a non-invasive treatment without accompanying side and adverse effects by individually controlling the FEL parameters (wavelength, power density, repetition rate).抄録全体を表示PDF形式でダウンロード (1541K) -
清水 洋, 物部 浩達, 粟津 邦男2003 年 31 巻 12 号 p. 811-817
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーIt was recently found that an alignment change of a columnar mesophase is induced by infrared laser incidence via vibrational excitation of a chemical bond constructing the molecular frame of mesogen. The new domain is quite stable to stand for several hours at the temperature. This phenomenon was not observed for conventional rod-like liquid crystals with relatively less viscous order of molecules such as nematic, smectic A and smectic C phases, indicating the strong anchoring force of the substrate surface is predominant for the alignment behavior. A relation in direction between the polarization of incidence and the transition dipole of the selected vibrational mode of the chemical bond was recognized. The present status of studies on alignment control of highly ordered mesophases is briefly shown with a simple introduction of liquid crystals and with studies on photoinduced alignment control in these years.抄録全体を表示PDF形式でダウンロード (1484K) -
森 伸也2003 年 31 巻 12 号 p. 818-823
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーFree electron lasers have unique advantages; wide-range wavelength tunability, ultrashort pulse operation and intense peak power. The high-power coherent laser beam in the mid-infrared (MIR) region provides unique opportunities to investigate carrier dynamics in semiconductors. Band-gap luminescence from a variety of compound semiconductors has been observed with an intense MIR radiation beam being directed to the samples. The band-gap luminescence is attributed to impact-ionization following scattering-induced free-electron heating.抄録全体を表示PDF形式でダウンロード (1011K) -
能丸 圭司, 黒田 晴雄2003 年 31 巻 12 号 p. 824-828
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーMid-infrared free electron laser (MIR-FEL) is an attractive light source for laser isotope separation because of its wavelength tunability and high output pulse energy. Several demonstrations have already done in the world FEL facilities. In this review, the recent results of isotope separation by use of MIR-FEL are described with our experimental result of silicon isotope separation by use of phenyltrifluorosilane.抄録全体を表示PDF形式でダウンロード (919K) -
河田 聡, 井上 康志2003 年 31 巻 12 号 p. 829-834
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーNear-field optical microscopy provides us with super-resolving capability of optical and spectroscopic imaging/sensing by confining photons within a much smaller region than their wavelength. In this article, we review near-field infrared microscopy and spectroscopy for chemical analysis and imaging of materials at nanometric scale. After brief introduction to near-field optics, key elements for realization of near-field IR microscopy are described. Then, we show several experimental results of near-field IR spectroscopy using a several kinds of IR light sources and near-field probes. Possibility for application of FEL to near-field IR spectroscopy is also discussed.抄録全体を表示PDF形式でダウンロード (1339K)
レーザーオリジナル
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鈴木-吉橋 幸子, 内藤 康秀, 石井 克典, 粟津 邦男2003 年 31 巻 12 号 p. 835-840
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーMatrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) is a powerful and robust tool for protein identification. We proposed a novel MALDI method (UV/FEL MALDI) based on simultaneous irradiation of a nitrogen laser (UV) and a free electron laser (FEL) to perform selective ionization, improving sensitivity and extending the upper limit of detectable molecular weight. Simultaneous exposure of UV and FEL showed some advantages over conventional MALDI cases. First, tuning FEL to an absorption wavelength of the matrix advanced the ionization efficiency. Second, multimers of keratin were observed up to approximately 900 kDa. These results suggest that UV/FEL-MALDI can be a more effective method for functional analysis of macromolecules and supramolecules of proteins than conventional used of MALDI.抄録全体を表示PDF形式でダウンロード (950K) -
深見 裕子, 鈴木-吉橋 幸子, 粟津 邦男2003 年 31 巻 12 号 p. 841-848
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーIn order to estimate the optimum laser conditions for efficient dissociation of cholesterol ester in an arterio-sclerotic region of blood vessels, we have investigated the relationship between the laser parameters and cholesterol ester dissociation using a MIR free electron laser (FEL). In this study, cholesteryl oleate, a typical cholesterol ester found in arteriosclerotic regions, was irradiated with 5.75-μm-FELs, which is known to cause vibration of ester bonds. The following results were obtained. (1) Ester dissociation depended upon the absorption coefficient. The macropulse duration was shorter than the thermal relaxation time, showing that the ester bonds dissociated into carboxylic acid and cholesterol by macropulse-induced thermal effects without accompanying thermal diffusion. (2) Using a wavelength of 5.75 μm, the maximum ester dissociation ratio was achieved under the optimum laser conditions of a macropulse energy density greater than 0.4 J/cm2. (3) 5.75-μm-FEL was estimated to dissociate cholesterol ester under endothelial cells without thermal damage.抄録全体を表示PDF形式でダウンロード (1659K) -
橋新 裕一, 山本 政志2003 年 31 巻 12 号 p. 849-853
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーIn this paper, we examine the pressure level and the wave form, which is the sound produced when incising biological tissue using a TEA-CO2 laser and a Middle-Infrared Free Electron Laser (MIR-FEL). The laser induced-sound pressure level is measured using a transducer with sensitivity in the range of 20 Hz to 70 kHz. We investigated the characteristics of sounds produced by the incision of soft and hard biological tissue using a laser. Focusing on the surface of the gelatin sample (a soft tissue), specifically on the water content at the point of incision, we estimated the water content from the surface electrical resistance, and found that there is a clear correlation between with the sound pressure level and the water content. Furthermore, we studied the FEL induced-sound of a wavelength around 10 μm for a hard biological tissue (a bone). As for the induced-sound wave form, we discovered that it was different to the result by the wavelength. This research is discussed in terms of the development of a photo-acoustic monitoring system for a safe, reliable laser scalpel and laser coagulation device.抄録全体を表示PDF形式でダウンロード (1171K)
一般論文
レーザーオリジナル
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出来 恭一, 松岡 史哲, 鄭 和翊, 有澤 孝2003 年 31 巻 12 号 p. 854-859
発行日: 2003年
公開日: 2006/02/03
ジャーナル フリーPulse compressor and amplifier using stimulated backward Raman scattering (SRS) of barium nitrate and calcite crystals are studied experimentally. 15 times of compression and more than 50 % SRS reflectivity were obtained with a 350 ps Nd:YAG fundamental laser as pump. Generation of two consecutive (the main and the second) pulses was observed in the Raman generator. A method to suppress the second pulse in Raman generator and selective amplification of the main pulse in Raman amplifier are also studied experimentally.抄録全体を表示PDF形式でダウンロード (638K)
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