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Volume 18, Issue 3
Displaying 1-16 of 16 articles from this issue
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[in Japanese]1986 Volume 18 Issue 3 Pages 168
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (162K) -
Toshiaki Abe, Kiyoko Ogawa1986 Volume 18 Issue 3 Pages 169-173
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe recent progress in the study on gangliosides, which are a family of acidic glycolipids containing sialic acids, is described. Structural studies of gangliosides have revealed that there are more than 60 kinds of molecular species, among which about 30 species are components of neural tissues. Since gangliosides have been shown to have some effects on neurite growth-promoting, many clinical trials on ganglioside treatment of patients with neurological diseases have been carried out.View full abstractDownload PDF (615K) -
Masaaki Fujita, Kunio Yoshino, Takayuki Ishihara1986 Volume 18 Issue 3 Pages 174-180
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSGastro-intestinal manifestations of 138 severely handicapped children were studied. Vomiting or hematemesis was most frequently observed; in 25 of all patients (18.1%) and in 13 of 38 bedridden patients (34.2%).
Transillumination of stomach or gastroscopy was performed in 20 patients. More than half of them had vomiting or hematemesis as a main symptom. Esophagitis due to gastroesophageal reflux or hiatal hernia was found in these patients, who had vomiting or hematemesis.
Symptoms of vomiting or hematemesis in severely handicapped children suggest the presence of esophgitis due to gastroesophageal reflux or hiatal hernia as a main cause.View full abstractDownload PDF (6750K) -
Experiences in Acute Hemiplegia in ChildhoodMasaaki Fujita, Kunio Yoshino, Takayuki Ishihara1986 Volume 18 Issue 3 Pages 181-185
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSGastro-intestinal manifestations of 138 severely handicapped children were studied. Vomiting or hematemesis was most frequently observed; in 25 of all patients (18.1%) and in 13 of 38 bedridden patients (34.2%).
Transillumination of stomach or gastroscopy was performed in 20 patients. More than half of them had vomiting or hematemesis as a main symptom. Esophagitis due to gastroesophageal reflux or hiatal hernia was found in these patients, who had vomiting or hematemesis.
Symptoms of vomiting or hematemesis in severely handicapped children suggest the presence of esophgitis due to gastroesophageal reflux or hiatal hernia as a main cause.View full abstractDownload PDF (8298K) -
Akashi Ishikawa, Etsuko Ishikawa, Masahiro Hagisawa1986 Volume 18 Issue 3 Pages 186-192
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAuditory brainstem response (ABR) and Brazelton's neonatal behavioral assessment scale (NBAS) were studied on 25 healthy full-term newborn infants. Significant correlations were found between ABR component latencies and the following NBAS scales: irritability, cuddliness, consolability with intervention and self-quieting activity. We concluded that neonates with early brain maturation showed high irritability, more resistive against the examiner's arms, low self-quieting activity in a fussing state and easily consolable with intervention.View full abstractDownload PDF (888K) -
Isamu Tamai, Makiko Okuyama, Toru Aoki, Yukikatu Ochiai1986 Volume 18 Issue 3 Pages 193-198
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSImmunological examinations were carried out on two sisters (10 years and 12 years old) with ataxia telangiectasia. Serum IgA and IgE were low, and serum α-fetoprotein was high. Also the specific IgG to Epstein-Barr virus capsid antigen was elevated. The number of peripheral lymphocytes was decreased, and blast formation to phytohemagglutinin, concanavalin A and pokedweed mitogen was low in response.
Delayed type skin reaction was decreased. OKT9 and OKT10 subsets of peripheral lymphocytes were increased. OKT3 and Leu 1 subsets were decreased. Furthermore, immunological studies showed that the percent of IgMFcR+ cell, OKT4, Leu 3A and Leu 4 subsets were decreased. The elder sister had an increase of anti-T cell antibody. These data suggested that these patients had a broad defect in lymphocyte maturation, as well as a helper T cell defect and that a brain associated T cell antigen between lymphocyte and brain-tissue affects the progressive mental deterioration of these patients.View full abstractDownload PDF (2662K) -
Hiroshi Inada, Hideji Hattori, Seijun Nakajima, Chiyo Iwamura, Akemi T ...1986 Volume 18 Issue 3 Pages 199-206
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe studied three children with subacute sclerosing panencephalitis (SSPE) who had been diagnosed between 1981 and 1983. They were treated with inosiplex and transfer factor, and one was given interferon. Clinical symptoms in all three patients sometimes improved for periods of several months. In two patients computed tomography (CT) first showed low density in the basal ganglia, which later improved and finally disappeared. In all three patients CT showed gradual enlargement of the ventricles and cerebral atrophy. Disappearance of the low-density areas may mean that some of the pathological changes of this disease, including inflammation, demyelination, and gliosis, are reversible. In two patients, we studied magnetic resonance imaging. The spin-echo images showed high intensity in the lateral portions of basal ganglia, in the parieto-occipital portions, and in the frontal portions. Inversion recovery images usually showed low intensity of the same lesions. We think that the MRI gave more useful detail than CT. We think that the improvement in the CT findings and clinical symptoms were due both to the treatment (inosiplex seemed to be especially helpful) and to the natural course of this disease.View full abstractDownload PDF (12103K) -
Masaru Tatsuno, Susumu Sunaga1986 Volume 18 Issue 3 Pages 207-211
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSEffects of electroconvulsive seizures (ECS) on the brain growth were studied using neonatal Sprague-Dawley rats. In order to eliminate the effects of nutritional factors, 3-day-old rats were subjected to insertion of intragastric canules, through which they received a milk formula for 7 days. Rats were divided into the ECS group and the control group. The ECS group received two supramaximal ECS per day for 7 days, and the control group was handled in a similar way but did not receive ECS. At the age of 10 days, no difference in body weight was seen between control and ECS groups. In the ECS group, we found a significant reduction in cerebral (-9.8%, P<0.05) and cerebellar weight (-17.0%, P<0.01) compared to those in the control group. In cerebellum, the ECS group showed significant reduction in the level of DNA (-26.5%, P<0.01). Also there was a slight reduction in contents of protein, RNA and cholesterol, but the difference between the two groups was not statistically significant. Our data suggest that ECS resulted mainly in a reduction of prolification of cerebellar cells.View full abstractDownload PDF (649K) -
Tatsuya Fujii, Takehiko Okuno, Haruo Hattori, Junko Ochi, Toshin Go, T ...1986 Volume 18 Issue 3 Pages 212-216
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSOne hundred and fifty-eight patients with partial epilepsy, in whom the age of onset was less than 15 years, were followed for more than 5 years. Seizures were classified according to the 1981 International Classification of Epileptic Seizures, and the prognosis according to the seizure type was evaluated.
Patients were divided into three groups:(1) those with simple partial seizures only (SPS);(2) those having complex partial seizures with or without simple partial seizures (CPS); and (3) those with partial seizures evolving to secondary generalization (PSG), which included cases with secondarily generalized seizures alone and those with both simple or complex partial seizures and generalized tonic clonic seizures. Incidences of the seizure-free state for more than three years were 66.7% for SPS, 56.7% for CPS, and 50.4% for PSG. The relapse rates were 0% for SPS, 6.7% for CPS, and 16.8% for PSG. The patients with PSG had a higher incidence of non-genetic etiological factors than those with SPS, had a higher rate of being complicated with mental retardation, existence of which significantly affects the prognosis, and were more likely to have the first seizure at less than one year of age. These findings indicate that the patients with PSG have more serious disturbances of the central nervous system than those with other seizure types, and this may account for their poor prognosis.View full abstractDownload PDF (664K) -
Satoko Nishimura, Tomoko Tanaka, Hiroki Takakura, Hidetoshi Tachibana, ...1986 Volume 18 Issue 3 Pages 217-222
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThree cases of Aicardi syndrome with an unusual complication were reported. They all had typical clinical features of the syndrome including infantile spasm, agenesis of the corpus callosum and chorioretinopathy. Case 1 (a 2-month-old female infant) had a lobar type holoprosencephaly and hepatoblastoma, Case 2 (a 5-year-old girl) had choroid plexus papilloma and Case 3 (a 11-month-old female infant) had a large cyst in the interhemispheric fissure. Infantile spasms were seeen at 1 to 3 months of age. The pregnancy was uncomplicated. Neither increase of TORCH titers nor chromosomal abnormalities were seen in their laboratory data. These cases may provide clues for the study of teratogenesis and oncogenesis.View full abstractDownload PDF (6956K) -
Pathological and Biochemical Studies on the Central Nervous SystemYasuhiko Hanaoka, Akihiko Sakai, Susumu Kurata, Masahiko Mizuno, Shuic ...1986 Volume 18 Issue 3 Pages 223-227
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSMenkes' kinky hair disease is characterized by mental retardation, abnormal scalp hair (sparse, kinky and hypopigmented), and low copper levels in serum. There have been only a few reports on serial CT examination and the pathogenesis of the central nervous system abnormality. This is a report of an autopsy case evaluated clinically by serial CT examinations with pathological and biochemical studies on the postmortem brain. Subdural hematomas separated by 2 membranes probably due to recurrent bleeding.
There were myelin-like structures, the cytoplasma and electron dense bodies in mitochondria of Purkinje and granular cells.
Biochemical analysis revealed lack of cholesterol ester of the brain. It was concluded that the abnormalities of white matter were caused by dysmyelination rather than demyelination.View full abstractDownload PDF (6799K) -
Yumi Horigome, Kenzo Hamano, Hiroshi Kanma, Kenji Shin, Hitoshi Takita ...1986 Volume 18 Issue 3 Pages 228-233
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe experienced a case of holoprosencephaly associated with endocrine abnormalities. A male neonate, one of twins, was born at 36 weeks of gestation. His birth weight was 2, 780 g. The other twin had no abnormalities. At birth, he had dyspnea and was immediately intubated. He had a single nostril, ocular hypotelorism and small ophthalmus. CT scan showed a single ventricle and a large dorsal sack, which were compatible with the diagnosis of holoprosencephaly. He died 26 hours after birth because of respiratory failure. Autopsy was performed and semilobar type of holoprosencephaly was confirmed. Also, absence of pituitary gland and hypoplasia of both thyroid and adrenal glands were observed, but the testes were normal. Serum pituitary hormones were examined; GH and TSH levels were very low, but FSH and LH showed normal values.
From these findings it was concluded that there existed an ectopic pituitary gland in this case, and that prosencephaly and pituitary gland dysgenesis had occurred simultaneously at 3 to 5 weeks of gestation, resulting in hypoplasia of thyroid and adrenal glands.View full abstractDownload PDF (4816K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1986 Volume 18 Issue 3 Pages 234-235
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1986 Volume 18 Issue 3 Pages 236-237
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1986 Volume 18 Issue 3 Pages 238-239
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
[in Japanese]1986 Volume 18 Issue 3 Pages 241-248
Published: May 01, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS
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