All issues
Volume 27, Issue 4
Displaying 1-14 of 14 articles from this issue
- |<
- <
- 1
- >
- >|
-
[in Japanese]1995 Volume 27 Issue 4 Pages 268
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (112K) -
Kazutaka Yamada, Shigenobu Tsuzura, Hiroshi Matsuda1995 Volume 27 Issue 4 Pages 269-275
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSingle photon emission computed tomography (SPECT) using N-isopropyl-p-[123I]-iodoamphetamine (123IIMP) was performed in twelve patients with severe athetotic cerebral palsy (Ath ; 5 males and 7 females) who had both motor delay (unable to move) and mental retardation (I. Q, or D. Q, below 30). The neuroimaging findings of those patients were compared with those of patients mental and motor disorders.
In five cases suffering from neonatal asphyxia, SPECT demonstrated a decreased regional cerebral blood flow (rCBF) in corpus striatum, thalamus, orbitofrontal areas, pericentral gyrus areas, prefrontal areas and medial temporal areas. In seven cases suffering from neonatal jaundice, SPECT demonstrated a decreased rCBF in orbito-frontal areas, prefrontal areas and medial temporal areas. SPECT showed hypoperfusion of peri-central gyrus areas in cases with complications of spastic palsy.
The decreased rCBF in medial temporal areas mostly corresponded to an alteration in hippocampal formation as assessed by magnetic resonance imaging (MRI). Cases with hypoperfusion of bilateral medial temporal areas showed a lower score of language understanding than those with the unilateral damage. In cases with hypofusion of bilateral prefrontal areas and bilateral medial temporal areas, the grade of understanding of language was almost below 12 months. In cases with hypoperfusion of orbitofrontal areas, psychomotor hypersensitivity had been observed.
Those results suggest that IMP-SPECT and MRI of the brain is useful tool for neurological assessment in handicapped patients with athetotic cerebral palsy.View full abstractDownload PDF (4955K) -
Masafumi Yanagihara1995 Volume 27 Issue 4 Pages 276-281
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSP 300 event-related potentials were recorded in 72 normal subjects ranging from 5 to 25 years of age for three visual discrimination tasks. A progressive decrease of P300 latency with curvelinear function was found in all the tasks. However, the age/P300 latency slope from 5 to 14 years was different for two word discrimination tasks and a color discrimination task, -17 ms/y (-16 ms/y) and -28 ms/y respectively. The curvelinear regression equation predicted the shortest latency of P300 to be observed at 26 years (28 years) in word discrimination tasks in contrast to 19 years in a color discrimination task. These results indicated the P300 latency varies depending upon the task type; different tasks require different modes of cognitive information processing. This fact should be taken into account when P300 latency is used for evaluating children's cognitive development.View full abstractDownload PDF (722K) -
Kimiko Yasuda, Katsuo Sugita, Hiromitsu Nakasa, Hiroo Niimi1995 Volume 27 Issue 4 Pages 282-285
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe predicted the serum level of a slow-releasing preparation of sodium valproate (VPA-SR) in 9 children with epilepsy by pediatric population parameter obtained previously or by two adult parameters. The accuracy of prediction was evaluated as an absolute error standing for the difference between the measured and the predicted serum concentration in each patient. The mean absolute error (MAE) based on the pediatric population parameter was 5.5±5.2%, although MAEs from two adult parameters were 13.8±9.9 and 15.1± 9.2%, respectively. Statistical analysis revealed that the pediatric population parameter was significantly more accurate for the prediction to serum concentrations. In conclusion, the pediatric population parameter was greatly useful for pharmacokinetic analysis of VPA-SR by Bayesian method in children with epilepsy.View full abstractDownload PDF (481K) -
Masatsune Date, Masahiro Gondoh, Shigetaka Kato, Masao Fukushima, Nats ...1995 Volume 27 Issue 4 Pages 286-290
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe studied a 2-year-old boy who had been diagnosed as having rubella encephalitis by detection of rubella virus genome in his cerebrospinal fluid with the reverse transcription-polymerase chain reaction (PCR). PCR was considered to be very useful not only to make an early diagnosis of rubella encephalitis but also to be applied generally to that of various viral encephalitis.View full abstractDownload PDF (4032K) -
Toshiyuki Yamamoto, Yukiko Nanba, Noriko Kodani, Yoshihiro Maegaki, Ma ...1995 Volume 27 Issue 4 Pages 291-296
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo cases of post-encephalitic epilepsy mainly characterized by auditory cognitive dysfunction were reported. In acute phase they only showed slight pleocytosis of CSF, and serum antiviral antibodies were all negative. Although their seizures were partial seizures with secondary generalization, their EEG and radiographic imaging did not show any lesions. Their waking state EEG continuously showed slowing with decrease of a activities. After clusters of convulsions, they showed delirium and aggressiveness. Both of them were thought to have post-encephalitic epilepsy with pathogen unknown and they were compatible with “a peculiar type of post-encephalitic/encephalopathic epilepsy” reported by Fukuyama and Awaya. The presented two cases were characterized by auditory cognitive dysfunction and intractable epilepsy with secondary generalization.View full abstractDownload PDF (736K) -
Junichi Oki, Aya Imanishi, Satoru Takahashi, Akie Miyamoto, Shigeru Ch ...1995 Volume 27 Issue 4 Pages 297-301
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 9-year-old right-handed girl was admitted because of complex partial seizures, left-right disorientation and finger agnosia. At the age of 2 years, she began to have seizures, which were exacerbated by carbamazepine and diazepam. Subsequently she was treated with phenytoin and phenobarbital, and remained seizure-free for four years. After age 7, she began to have attacks of alteration of consciousness, which lasted 10 seconds and occurred every two or three months.
At age 9, neuropsychological testing revealed borderline intellectual functioning (WISC-R: FSIQ 83, VIQ 94, PIQ 73), but selective deficits were found in tests of calculation and spacial-figural relationships. Axial spin echo (3, 000/22) image showed an abnormal high signal intensity in the left temporo-parietooccipital lobe, in which interictal IMP- SPECT demonstrated decreased cerebral blood flow. These results seemed to explain the relationship between clinical findings and focal migration disorder. It is important to detect a focal migration disorder in patients with intractable focal epilepsy or higher cortical dysfunctions.View full abstractDownload PDF (2335K) -
Mika Matsui, Hideo Shimoizumi, Shigeichi Kobayashi1995 Volume 27 Issue 4 Pages 303-308
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 6-year-old boy with hereditary motor and sensory neuropathy (HMSN), congenital cataract and mental retardation was reported. The condition commenced with distal weakness and wasting of lower limbs. Subsequently marked right pes cavus and equinovarus deformity appeared. Motor and sensory conduction velocities in the limbs were slowed. Pathological examination of biopsied sural nerve showed significant loss of large myelinated fibers. Neither demyelination nor onion bulbs were observed. For clinical and neuropathological findings, the present case did not fit in with previously reported cases of HMSN. The case was classified as a new variant of HMSN type II.View full abstractDownload PDF (5907K) -
Seigo Korematsu, Osamu Kobayashi, Naoki Fukushima, Hiroto Sawaguchi, T ...1995 Volume 27 Issue 4 Pages 309-314
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA patient with non-Fukuyama type merosin-positive congenital muscular dystrophy (nonFCMD) who had severe muscle weakness leading to early death was reported. He was the first product of epileptic mother who had been placed on phenobarbital and phenytoin. The patient had severe respiratory failure and muscle weakness at the neonatal period, and died at 4 months of age. Multiple joint contractures were also noted at birth. Serum creatine kinase was within normal limits (123 IU/l). Electromyography showed a myogenic pattern. Brain computed tomographic (CT) scan and magnetic resonance imaging (MRI) were normal without white matter lucency or pachygyria. Muscle biopsy revealed dystrophic changes and type 2 C fiber predominance. Dystrophin, dystrophin-associated glycoproteins and merosin were all positively demonstrated.
Although patients with merosin-positive nonFCMD have relatively mild clinical course, our patient had severe muscle weakness with fatal outcome. Defect in muscle fiber maturation and differentiation, such as an increase of undifferentiated type 2C fibers, may be a major factor to influence muscle symptoms in non FCMD.View full abstractDownload PDF (10776K) -
Kyoko Hoshino, Keiichi Morooka, Hiromi Imai, Kazue Takagi, Kiyoshi Ari ...1995 Volume 27 Issue 4 Pages 315-319
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 1-year-and-9-months old boy with gait disturbance during the 3rd week of Kawasaki disease (KD) was described. He had been previously healthy, and developed high fever and rash. The diagnosis of KD was based on 5 of 6 major criteria on the 3rd clinical day. He was initially treated with intravenous γ-globulin 400 mg/kg/day for five days. On the 17th clinical day, the patient developed gait disturbance after most clinicalsigns disappeared. His gait was wide-based and unstable. Generalized hypotonia with poor traction response was also seen. Pyramidal tract signs including exaggerated patellar and Achilles tendon reflexes and positive bilateral Mendel-Bechterew reflex were presented. Cerebrospinal fluid was normal. Brain CT, MRI, and 123I-IMP SPECT images were normal without broad hemorrhage or infarction of the cerebral parenchyma. Gait disturbance recovered spontaneously within one month without any sequelae.View full abstractDownload PDF (3420K) -
[in Japanese]1995 Volume 27 Issue 4 Pages 321-323
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1995 Volume 27 Issue 4 Pages 324-327
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1995 Volume 27 Issue 4 Pages 327-329
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
[in Japanese]1995 Volume 27 Issue 4 Pages 335-341
Published: July 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (981K)
- |<
- <
- 1
- >
- >|