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Volume 6, Issue 5
Displaying 1-11 of 11 articles from this issue
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[in Japanese], [in Japanese]1974 Volume 6 Issue 5 Pages 338-339
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (2300K) -
Kazuie IINUMA, Akira ONUMA, Muneyuki TANABU, Norimitsu TAKAMATSU1974 Volume 6 Issue 5 Pages 340-348
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA clinical study on the central nervous system involvement was done in 4patients with congenital muscular dystrophy (Fukuyama type).
Pneumoencephalographic examination was made in 3 cases. It was found that these patients had ventricular dilatation and air accumulation at the outside of the ventricular system, especially at the insular portion, and the wide communication between the fourth ventricle and cisterna magna. These observations suggest the presence of atrophy of insular portion and cerebellar vermis.
The carotid angiography showed that patients had the medio-dorsal displacement of Silvius sulcus portion of the middle cerebral arteries, also suggesting the atrophy of the insular portion.
In the electroencephalographic findings, the resting record showed 10 to 16 per second fast activities for age in those 4 patients. The sleep record showed about 10per second regular activities in spindle form mainly at the frontal areas, and those activities seemed to be transformed into extreme spindles with aging.
The ophthalmologic examination revealed pathological findings such as optic atrophy (3 cases) and pigmentation at the peripheral part of the retina (1 case).
These central nervous system symptoms seemed to be specific findings in the Fukuyama type of congenital muscular dystrophy.View full abstractDownload PDF (3892K) -
Kenichiro HIGASHI, Mitsunori HATANO, Kozo HIRAOKA, Eitaro SUZUKI1974 Volume 6 Issue 5 Pages 349-357
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSNine infants of purulent meningitis with complications requiring surgery have been treated in our clinic during the period from 1970 to 1972. These complications consisted of 7 cases of hydrocephalus, 1 brain abscess and 1 subdural abscess.
For hydrocephalus, a ventriculo-peritoneal shunt was carried out following observation for at least two months after CSF became aseptic. In spite of such cautious treatment, most of the patients required frequent revision of shunts due to obstruction or infection of shunt valves. Long-lasting high concentration of protein and/or pleocytosis in CSF impedes the potency of shunt valves. In order to overcome such obstacles, we employed either frequent removal of ventricular fluid by means of a subcutaneously placed Ommaya reservoir or lavage of the ventricles so as to dilute the concentrated CSF. Both methods produced successful results. The patient with brain abscess died after surgery for hydrocephalus, while the patient with subdural abscess reco vered completely after drainage of the abscess cavity.
In our experience, surgical intervention to treat these complications of purulent meningitis yield good results unless the patient has had neurological deficits preoperatively. Therefore, surgical treatment must be performed as early as possible, well in advance of development of irreparable brain damage.View full abstractDownload PDF (4688K) -
Ken FUJITANI, Anatole S DEKABAN, Andrew W ZIMMER1974 Volume 6 Issue 5 Pages 358-362
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDetermination of serum levels and urinary excretion of PB, DPH, and PRM in a group of children and a group of adults with epilepsy were conducted. On comparable or higher doses per kg body weight, children had lower mean values of serum levels of all drugs tested than the adult patients. The excretion of PB (whether derived from the intake of PB or PRM) was also lower in children; this finding is consistent with faster catabolism of PB in children. The means of dose excretion ratios of PRM was about the same in children as in adults. The urinary excretion of DPH by the patients of both groups was negligible. Potential factors influencing metabolism of anticonvulsant drugs were considered.View full abstractDownload PDF (554K) -
Toru KUROKAWA, Kiyoshi YOKOTA, Akihisa MITSUDOME, Rumiko SHIBATA1974 Volume 6 Issue 5 Pages 363-370
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDiagnostic value of EEG with intravenous injection of Diazepam was assessed in terms of localization and severity of brain damage on 20 cases of childhood epilepsy, including infantile spasms (11 cases), other types of generalized seizures (3 cases) and partial or unilateral seizures (6 cases).
The results are summarized as follows:
1) EEG with i.v. injection of Diazepam showed localized epileptic discharges in 7% of generalized seizure cases and in 67% of partial-unilateral seizure cases. 2) Drug induced low voltage fast activity (LVFA) did not appear in the region of cerebral damage. 3) LVFA diffusely appeared in three out of five cases with normal psychomotor development, while LVFA were well induced only in one case out of 15 cases with developmental retardation. 4) Epileptic discharges were not suppressed in all ten cases with abnormal pneumoencephalographic findings and/or microcephalus. LVFA were not induced in nine cases of them. 5) Seizures ware completely controlled after ACTH or steroid therapy in four out of five cases with good suppression response of epileptic discharges to i.v. injection of Diazepam. On the other hand, seizures were not controlled in four out of five cases with poor response.
In conclusion. EEG with i.v. injection of Diazepam was useful in evaluating pathophysiological status and prognosis of childhood epilepsy.View full abstractDownload PDF (1514K) -
Kenji NIHEI, Hiromichi MIZUTANI1974 Volume 6 Issue 5 Pages 371-377
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSAlthouth the pathogenesis of Schilder's disease remains obscure, there is a suggestion that a slow virus infection might be responsible for initiating the disease.
Single sera from 4 cases of Schilder's disease, 2 cases of SSPE and 12 cases of multiple sclerosis were examined for HI antibodies to measles, parainfluenza I-IV SV5, rubella and vaccinia viruses. Significantly higher measles antibody titers than control subjects were obtained only in patients with SSPE.
Increased relative cerebrospinal fluid concentrations of Ig-G were also found in patients with Schilder's disease, as well as in patients with SSPE and multiple sclerosis.
The in vitro macrophage migration inhibition assay demonstrated the presence of hypersensitivity to brain tissue antigen in patients with Schilder's disease, as well as in patients with SSPE and multiple sclerosis.
The cellular hypersensitivity to measles antigen was demonstrated only in patients with SSPE.
A possible explanation was prsented for these findings that a similar immunological mechanism might be associated with the aetiology of Schilder's disease and multiple sclerosis.View full abstractDownload PDF (939K) -
Considerations on the diagnosis of congenital Minamata disease from two casesMasazumi HARADA1974 Volume 6 Issue 5 Pages 378-387
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTwo patients with mental deficiency born in 1956 and 1958 in Minamata city were reported. Idiocy, dysarthria, athetosis, chorea, paroxysmal symptoms and clumsiness of movements were observed in either of these patient. In Case 2, strabismus and hypersalivation were also found.
The patients were diagnosed as exogenic mental deficincy.
They were born at the area and during the period of the outbreak of the congenital Minamata disease. The mothers of the patients had eaten a lot of fish or shell-fish contaminated by methyl mercury compounds, and presented some symptoms of the Minamata disease. Any other cause of the disease could not be found in their life history.
Although the neurological symptoms and motor disturbances in the patients were milder than those in the previously reported congenital Minamata disease cases, I conclude that the mental deficiency in these patients were caused by methyl mercury, which had affected during the fetal period. This fact seems to suggest that some mild or atypical cases of the congenital Minamata disease may appear clinically as mental deficiency only.
Finally, the diagnosis of the congenital Minamata disease was discussed.View full abstractDownload PDF (3198K) -
Kazuko MARUYAMA, Hiroshi MARUYAMA1974 Volume 6 Issue 5 Pages 388-396
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTwo patients with “head nodding reflex” were described. The reflexes were elicited immediately by stretching fingers in one case, and by sucking in the other. Both patients had cerebral palsy, classified as tension-athetoid quadriplegia and spastic diplegia respectively. However, they showed both spasticity and athetoid movements to some extent.
Non-epileptic nature of the reflex was acertained on electroencephalogram, which did not demonstrate the relationship between the wave pattern and the elicited reflexes.
The reflex was not suppressed by antiepileptic drugs, but was reduced or abolished by levodopa.View full abstractDownload PDF (4443K) -
Masao KINOSHITA, Nobuyuki KAMEI, Yutaka TSUCHIYA, Takasumi ASAISHI, Mi ...1974 Volume 6 Issue 5 Pages 397-403
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA 11-year-old boy and his 40-year-old mother were presented. Both patients had an identical clinical features with long, thin face, nonprogressive weakness and atrophy of the limbs since childhood, high arched palate, scoliosis and normal serum CRK levels. Muscle biopsies also showed completely identical change with selective atrophy of type I and hypertrophy of type II fibers. The changes of cellular structures of the fibers were almost negative except for rod bodies in the occasional areas in both cases. The disorder of this family might have been same as socalled nemaline myopathy, because the selective type I fiber atrophy has been common in certain number of the reported cases.
However, in this family, the evidence for nemaline myopathy was minimal and was insufficient to establish the diagnosis. In addidtion, whether the disorder was neurogenic or myopathic in origin was also obscure.
The connection of this family to congenital fiber type disproportion of Dubowitz was also discussed, and finally it was considered to be proper to term the neuromuscular disorder in this family simply “type I fiber atrophy”. Possible pathogenesis of selective type I fiber atrophy was briefly discussed.View full abstractDownload PDF (6307K) -
Vergleichende Diskussion mit foetalen heterotopischen Zellmassen im gleichen OrtAkira HORI, Masaaki MATSUSHITA, Kunshi MUROFUSHI, Reiji IIZUKA1974 Volume 6 Issue 5 Pages 404-408
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDie im Kleinhirnmark als Zufallsbefund zu beobachtenden Nervzellheterotopien wurden schon bei Foeten als heterotopische Zellmasse beobachtet. Bei Foeten sind die heterotopischen Zellen viel weniger differenziert als die des Zahnkerns.
Sie werden so oft bei Foeten gefunden (27.7%), daißsie als Normvariant gedacht werden könnten. Nicht alle Heterotopien bei Foeten wurden ent wickeln, sodaß sie seltener bei Infanten (20.0%) und bei Erwachsenen (13.3%) wären. Bei einem 80-jährigen Patienten fand sich eine Pseudokal kablagerung in der Grundsubstanz der Hetero topie.View full abstractDownload PDF (4771K) -
[in Japanese]1974 Volume 6 Issue 5 Pages 409-412
Published: September 01, 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (3482K)
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