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Volume 27, Issue 1
Displaying 1-16 of 16 articles from this issue
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[in Japanese]1995 Volume 27 Issue 1 Pages 2
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
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Kyokazu Ono, Junji Uematsu, Chie Ishizuka, Akira Aisaka, Yoshiro Watan ...1995 Volume 27 Issue 1 Pages 3-9
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe corticospinal tract in the rat after neonatal ablation of the unilateral cerebral cortex was studied morphologically using the antegrade horse-radish peroxidase (HRP) tracing method. An aberrant ipsilateral tract was observed 7 days after the operation. Formation of the aberrant neuronalpathway has been confirmed to be contributed mainly by new axons, which ramified at the level of the pyramidal decussation from healthy corticospinal fibers. This ramified axon ran toward the ipsilateral dorsal funiculus. A few fibers also contributed to the aberrant pathway by changing their direction on the way of extension at the level of the pyramidal decussation. These results indicate that the ramification and change of the direction of extending axons play an important role for formation of a new ipsilateral corticospinal tract.View full abstractDownload PDF (12269K) -
Kazuya Goto, Koichi Wakayama, Tomoki Maeda, Naoki Fukushima, Tatsuro I ...1995 Volume 27 Issue 1 Pages 10-16
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSUsing a software program for measuring surface area, we quantified the relative size of four parts of the lateral ventricles, including the body, the trigone, the anterior horn and the occipital horn, compared to the hemispheres in the axial plane of magnetic resonance imaging (MRI) in neonates. In 44 neonates without any neurological disorders from 26 to 41 weeks of gestational age (GA), MRI was performed between 12 and 124 postnatal days.
The mean of the relative size of the ventricle compared to the hemisphere (RSVH) among the subjects showed a significant left-right asymmetry that was observed only in the occipitalhorn. However, in the body, the anterior horn and the occipital horn, the percentage of neonates with alarger left RSVH compared to the right RSVH was significantly higher than the percentage of neonates with a larger right RSVH compared to the left RSVH. The RSVH of the body and the occipital horn increased according to the number of postnatal days and decreased according to GA.
Measuring RSVH was useful in assessing the size of the ventricle in the axial plane of neonatal MRI. It clarified the fact that normative asymmetry, GA of subject, and the number of postnatal days should be considered in assessing the size of ventricle.View full abstractDownload PDF (2963K) -
Yukio Arai, Sachiko Yoshihara, Kazuso Iinuma1995 Volume 27 Issue 1 Pages 17-22
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSComputed tomographic images of brains from 26 individuals (10 males and 16 females) with Down syndrome were analysed for roentogenographic measurement. Their ages ranged from 14 to 47 years, the average being 28 years. The results showed that their Sylvian fissure ratio was larger in the aged group. A high incidence of calcification in basal ganglia, choroid plexus and pineal body was noted (85%). An increased Sylvian fissure ratio and a high incidence of intracranial calcification may be practically used as representatives of premature aging. Furthermore, a high incidence of mega cisterna magna implicates that it is worthy of study whether individuals with Down syndrome have a predisposition to underdevelopment of cerebellum.View full abstractDownload PDF (609K) -
Akie Miyamoto, Satoru Takahashi, Junichi Oki, Junichi Itoh, Kazuhiko C ...1995 Volume 27 Issue 1 Pages 23-28
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe treated one hundred and seventy-eight epileptic children with carbamazepine (CBZ) for eight years. Among them, four children with symptomatic localization-related epilepsy, aged 11 months to 12 years, developed exacerbation of seizures. Their epilepsies were associated with hypoxic ischemic encephalopathy, head injury and ectopic gray matter. Despite the serum levels of CBZ (7.0-9.5μg/ml) being within the therapeutic range, all of them had more frequent and severe partial seizures than before taking CBZ and one developed new atonic seizures. Diffuse irregular spike-wave complexes appeared on EEG in two children. Following discontinuation of CBZ in addition to replacement with phenytoin, their seizures became wellcontrolled and EEG findings improved except for residual focal spikes. Although CBZ is a widely used and effective antiepileptic drug for partial seizures, it should be kept in mind that CBZ may exacerbate seizures in children with symptomatic localization-related epilepsy.View full abstractDownload PDF (720K) -
Seigo Korematsu, Kazuya Goto, Takanobu Ishihara, Shun Ishiwa, Tatsuro ...1995 Volume 27 Issue 1 Pages 29-34
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo patients with Sotos syndrome showed very intractable and prolonged status epilepticus, resulting in poor outcomes. Clinical seizures and EEG abnormalities in patients with Sotos syndrome are sometimes noted, but they are usually mild. These two patients showed hypoplasia of corpus callosum on MRI. We considered the mechanism of intractable seizures, and emphasized the importance of careful management for their seizures and EEG abnormalities.View full abstractDownload PDF (4749K) -
Susumu Sumitani, Yukitoshi Ishikawa, Yuka Ishikawa, Ryoji Minami1995 Volume 27 Issue 1 Pages 35-40
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe reported a 12-year-old boy with Emery-Dreifuss muscular dystrophy (EMD). He was born after uncomplicated full term pregnancy and delivery. There was neither consanguinity nor a history of neuromuscular disorders or cardiac diseases in his family. He walked at 14 months. Toe walking was recognized at age 5 years. Examination at age 12 years showed the following. He could walk and climb stairs. There was no Gowers' sign. He had mild weakness of muscles except for face muscles. He had joint contractures at heels, elbows and knees. Deep tendon reflexes could not be elicited. Serum creatine kinase activity was significantly raised. Electromyography showed a myogenic pattern. Muscle biopsy from the left quadriceps showed mild dystrophic changes. 24 h Holter monitoring showed atrioventricular block with Wenckebach phenomenon.
Prognosis in EMD is strongly connected with cardiac involvement. Therefore, we must follow up this case carefully for cardiac symptoms.View full abstractDownload PDF (4548K) -
Mitsumasa Fukuda, Takehiko Morimoto, Hiroshi Matsuda, Hideo Nagao, Hir ...1995 Volume 27 Issue 1 Pages 41-46
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe reported a 6-year-old girl with acute idiopathic pandysautonomia (AIPD) associated with syndrome of inappropriate secretion of anti-diuretic hormone (SIADH). She showed various symptoms indicating the impairment of widespread sympathetic and parasympathetic nervous functions and SIADH, which followed common cold. Sural nerve biopsy showed severe reduction of both myelinated and unmyelinated fibers.
The main site of the lesion of AIPD has been assumed to be the peripheral autonomic nervous system. However, there are a few reports indicating the involvement of the central nervous system in AIPD. The present case also indicates the involvement of hypothalamus in addition to the peripheral autonomic nervous system.View full abstractDownload PDF (5305K) -
Kei Shioda, Kuniyasu Takada, Masao Minagawa, Yukio Shimizu, Toshiyuki ...1995 Volume 27 Issue 1 Pages 47-52
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA rare adult autopsy case of Down syndrome was reported. The patient was a 36-year-old male, whose chromosome analysis revealed 47, XY, +21. He showed typical systemic AA-amyloidosis and numerous senile plaques in the brain. Senile plaques were diffuse or primitive. They were composed of β-protein, but negative for Congo-red stain. There were few neurofibrillary changes in the para hippocampal gyri. Nucleus basalis Meynert showed no significant lesion. The distribution of these plaques had some characteristics different from that for Alzheimer's disease. In the brain involvement of systemic AA-amyloidosis was restricted to the regions devoid of blood-brain-barrier, such as choroid plexus and pituitary gland. Cerebral β-amyloid and systemic amyloid A protein were segregated on each side of the blood-brain-barrier. Therefore, we suggested that each amyloid might be synthesized and deposited by its own mechanism. Electronmicroscopically Hirano's body was identified in the hippocampal gyri.View full abstractDownload PDF (8264K) -
Correlation between Clinical Severity and Dystrophin TestingYukitoshi Ishikawa, Yuka Ishikawa, Susumu Sumitani, Ryoji Minami1995 Volume 27 Issue 1 Pages 53-57
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSince the 14kb human Duchenne muscular dystrophy (DMD) cDNA was cloned and its protein product “dystorphin” was discovered, immunochemical, biochemical and genetic analyses of dystrophin (dystrophin testing) have provided an accurate diagnosis of DMD/Becker muscular dystrophy in the clinical field. We performed dystrophin testing for a 5-year-old boy and confirmed he had severe BMD. Multiplex PCR of the DMD gene showed in-frame type deletion from exon 45 to 48. Immunohistochemical analysis of the muscle specimen obtained from the patient showed a discontinuous and patchy staining pattern, using monoclonal antibody that recongnizes the C-terminus domain of dystrophin. On immunoblot analysis, we detected a faint band of 390 kDa. Dystrophin quantity was less than 10% of that compared to normal controls. The correlation between clinical severity and dystrophin testing was discussed.View full abstractDownload PDF (5951K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1995 Volume 27 Issue 1 Pages 58-60
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese]1995 Volume 27 Issue 1 Pages 60-62
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
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[in Japanese]1995 Volume 27 Issue 1 Pages 62-64
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese]1995 Volume 27 Issue 1 Pages 65-67
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese]1995 Volume 27 Issue 1 Pages 68-70
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
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[in Japanese]1995 Volume 27 Issue 1 Pages 75-77
Published: January 01, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3333K)
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