Japan is a sleepless country in the world. The social structure is always complicated and it is difficult to secure sleep due to labor shortage and long working hours. Therefore, it is important to improve the quality of sleep, and we focused on the meal. In particular, lipids such as omega-3 fatty acids, phospholipids and choline compounds are related with central functions. This review introduces the author’s studies and the relationship between lipid intake and sleep.

Sleep plays an important role in metabolic regulation and insomnia disorder, short sleep and long sleep are also related with dyslipidemia. Among them especially, numerous evidence suggests that sleep disordered breathing is closely associated with dyslipidemia, hypertension and diabetes, and increases the risk of cardiovascular disease. In addition, in recent years, studies that elucidate the molecular mechanism of dyslipidemia due to sleep disorder by a mass spectrometer is increasing. The relationship between severity and lipid species profile in patients with obstructive sleep apnea has been reported, and the previous study revealed a significant overall shift in lipid metabolism, with higher levels of phospholipids under sleep-restricted conditions. Comprehensive analysis of lipid metabolites using a mass spectrometry further the understanding of sleep/wake regulation and the associated metabolic processes, and will be vital to identify robust biomarkers for disease states and drug efficacy. In this paper, we review epidemiological and mass spectrometric studies on the relationship between sleep and dyslipidemia.

In recent years, many studies have revealed that sleep and general health are closely related. The social and economic loss caused by sleep problems in Japan is estimated to be 15 trillion yen a year, and the social significance of improving sleep is to be important. In this paper, we will report on the development of “Foods with Function Claims” that improves the quality of sleep, focusing on the findings of "Sake Yeast GSP6" and its effect of sleep improvement. In addition, as part of the study of general health through sleep, we will also introduce the improvement of skin quality and the reduction of fatigue by the improvement of sleep quality.