Oleoscience
Online ISSN : 2187-3461
Print ISSN : 1345-8949
ISSN-L : 1345-8949
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Volume 4, Issue 5
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  • Development of Water Soluble Eicosapentaenoic acid·Docosahexaenoic acid Derivative and it Physiological Function
    Hidehiko HIBINO
    2004 Volume 4 Issue 5 Pages 197-202
    Published: May 01, 2004
    Released on J-STAGE: June 01, 2013
    DOIhttps://doi.org/10.5650/oleoscience.4.197
    JOURNAL FREE ACCESS
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    The author established the method of compounding water-soluble EPA·DHA derivative, and evaluated the physiological function of the substances. This substance is α-amino acid-N-PUFA-sodium salt (AAS). AAS is the powder of the letter of a white crystal, and the solution is transparent and colorless. AAS induces EPA and DHA to acid-chloride, combined with the amino group of mono sodium glutamate or glutamic acid diethylester. AAS reduces the hemolysis of free fatty acid;EPA and DHA and deteriorate the survival rate of the cell which aquired tolerance to the antineoplastic drug.
    Since AAS can make EPA and DHA water-solubility, using it for medical supplies, such as a nutrition agent and a curative medicine, and a food field widely is expected.
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