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Volume 27 (1975)
- Issue 6 Pages 449-
- Issue 5 Pages 405-
- Issue 4 Pages 315-
- Issue 3 Pages 169-
- Issue 2 Pages 83-
- Issue 1 Pages 1-
Volume 27, Issue 2
Displaying 1-5 of 5 articles from this issue
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Tatsuya ISHIGUXO1975 Volume 27 Issue 2 Pages 83-94
Published: March 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSThe developmental features of immunologic response and antibody-eliciting capacity of peritoneal macrophages obtained from the immunologically mature adult as well as immature suckling rats were studied. Sheep red blood cells (SRBC) were used as the test antigen and the antibodyforming activity was assessed by the number of hemolytic plaque-forming cells per unit number of spleen cells or the hemagglutinin titer of the serum or both. It was found that suckling rats younger than 14 days of age lacked a primary response to SRBC. The initial appearance of demonstrable 19S-PFC was at the age of 14 days. 19S-PFC in rats older than 14 days of age increased in number in correlation with age, and by about 50 days the number of 19S-PFC reached the adult level. It was shown that transplantation of the SRBC-containing macrophages derived from adult rats elicited the apparently normal antibody response in adult recipients but not in the immunologically deficient suckling animals. It was also found that the macrophages of the suckling rats were capable of ingesting SRBC and of transferring the antibody-eliciting capacity when transplanted into normal adult rats after ingestion of the antigen.
It was concluded from these findings that maturation of the phagocytic as well as antigenprocessing capacity of macrophages preceded the differentiation of immunologically competent, antigen-reactive cells or the precursor of antibody-forming cells or both.View full abstractDownload PDF (3264K) -
Tadafumi SHIMAMOTSO, Sachio OGITA, Masanori OHNISHI, Hideharu NOMA, Os ...1975 Volume 27 Issue 2 Pages 95-99
Published: March 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSTo date it is realized that neonatal icterus closely relates to the function and maturity ofnew born liver.
That is to say, neonatal icterus depends on the activity of enzymes concerned bilirubin metabolic pathway such as UDPG-dehydrogenasaen d UDP-gluculonyltransferase.
On this view point, the activity of UDPG-dehydrogenasea nd UDP-gluculonyltransferase in the rat liver was measured during development of the fetus and in the neonatal period.
Although both enzymes have very low activity in the fetus, activity of the enzymes gradually elevates in the neonatal period.
The results obtained indicate these enzymes might be adaptive enzymes hence the possibility of inducing these enzymes by the respective substrate was considered. So, Bucolome (5-n-Butyl-1-cyclic-2, 4, 6-trioxoperhydropyrimidinew) as injected to new born rats, and significant elevation of the UDP-gluculonyltransferasea ctivity was observed after 5 days from the initial injection.
Daily administration of Bucolome to pregnant rats for 7 days resulted increase of the enzymes of new born rat liver, while UDPG-dehydrogenaswe as not influenced. On the basis of these experimental results, Bucolome was administrated retrospectively over 10 days daily to 30 pregnant women who have ABO incompatibility.
The new born infants treated with Bucolome showed significantly low bilirubin levels compared with non treated infants.View full abstractDownload PDF (530K) -
Shinpei TANAKA1975 Volume 27 Issue 2 Pages 101-103
Published: March 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSA clinical use of antibiotics during pregnancy may raise a sereous problem of placental transfer as well as in vivo dynamics of mothers.
This problem is particularly noteworthy in cases with renal impairment and varies depending upon the antibiotics to be used.
In vivo dynamics of cephalosporin C were investigated in normal pregnant women as well as in cases of toxemia, and also experimental study using non-pregnant, normal pregnant and renal impaired pregnant rabbits was performed.
The following results were obtained:
1) In vivo dynamics of cephalosporin C was changed by the difference in the side chains of cephalosporin C.
2) In normal pregnant rabbits and normal pregnant women, serum concentration of cephalosporin C showed prolongation as the gestational advances.
3) Regarding to the normal pregnant and renal impaired rabbits, a CER administered group showed apparently much greater placental transfer rate, especially the transfer rate to the amniotic fluid was remarkedly increased in comparison with CEZ and CET administered groups.
This result suggested the close relationship between cephalosporin C and serum protein binding rate.
4) In cases of toxemia, half-life of cephalosporin C in serum was prolonged and urinary recovery was decreased.
5) Treated cases of toxemia with clinical improvement induced the shortening of biological half-life and increase of urinary recovery of CEZ, but one case with severe renal impairment the behavior of CEZ failed to alter in a short period of time.View full abstractDownload PDF (429K) -
Sadamu NODA, Sadao TERAMUSA1975 Volume 27 Issue 2 Pages 105-114
Published: March 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSIn places such as Osaka or Tokyo, which are the most densely populated cities in Japan, detection methods suitable for smaller places are not fast enough. In Osaka alone there are 2, 000, 000w omen possibly eligible for government-directed mass-screening using cytology;but it is impossible under present circumstances to screen them all. Therefore since December 1968 we have been using the private surgeries of about 800 local gynaecologists, scattered evenly over Osaka Prefecture.
However, even after five years we have made only minimal progress.-Only 22, 258 have been checked by this method. How can we improve on this? Conclusions were:If we consider that a working year is only actually 10 months, and that a working month is only actually 20 days, and that a working week is only actually five days, then even so, if 800 gynaecologists every working day screened 5 people using cytology they could all individually screen 1, 000 per year. Thus, the yearly grand total could be 800, 000. And this number is larger than 600, 000 that is CAI (Cytology Activity Index) 300 in Osaka.
If we worked on the basis suggested by statistical averages, we may find that only 60, 000, i. e. 10%, would need to be re-checked at hospital. This is not an impossible number, as we have over 140 hospitals, and they individually could re-check 3 persons per day very easily. Thus, if 140 hospitals each re-checked 3 persons per day, this would mean 60 persons per month, and 600 per year at each individual hospital. Thus the grand total could be over 80, 000, which is more in fact than suggested in this report. And this is still a workable number.
However, WHO can work to decrease the number from 600, 000 to 60, 000? Clearly the establishment of a public Cytology Center is the first and greatest essential for determining the present and future development of uterine cancer detection using cytology.View full abstractDownload PDF (1153K) -
Keizo INOUE, Asaji ICHIMONJI, Yoshihiro TAKAHASHI, Tsuneo NODA1975 Volume 27 Issue 2 Pages 115-118
Published: March 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSA case of leiomyoma of the stomach confirmed by laparotomy under the diagnosis of ovarian tumor was described.
A 63-year-old female suffering from tumor formation in the lower abdomen was hospitalized May 20, 1974. A firm, movable and child's head sized mass was palpable in the lower abdomen. X-ray films of the stomach, gastrocamera, hystero-salpingography, pyelography and echo-scanning gave a impression of ovarian tumor.
A hard and exogastric tumor, 18×14.5×13cm, was identified on the greater curvature of the stomach by laparotory. Subtotal gastrectomy was done. Histological examination of this tumor revealed a leiomyoma.View full abstractDownload PDF (3942K)
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