All issues
Volume 36 (1984)
- Issue 6 Pages 579-
- Issue 5 Pages 471-
- Issue 4 Pages 313-
- Issue 3 Pages 195-
- Issue 2 Pages 97-
- Issue 1 Pages 1-
Volume 36, Issue 6
Displaying 1-4 of 4 articles from this issue
- |<
- <
- 1
- >
- >|
-
Yoshimasa TSUJI1984 Volume 36 Issue 6 Pages 579-594
Published: November 01, 1984
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSUtero placental blood flow (UPBF) and placental function is important for fetal growth.
In an attempt to accelerate UPBF and placental function of IUGR pregnant rat model, I tried theophylline administration as a new therapy.
Rat IUGR model was made by actinomycin-D (AcD) method (AcD 0.07μg/g was injected intraperitoneally to pregnant rats on 14th day of gestation) or made by microspheres (Msp) method (Msp was injected into abdominal aorta to decrease placental blood flow on the 18th day of gestation).
Then, at the 16-20th day or 18-20th day of gestation, the IUGR model rats were administered twice a day with 2.5mg of Th (AcD+Th group or Msp+Th group) or 2.5ml of saline (AcD+saline group or Msp+saline group).
The following result was obtained:
1) At the 20th day of gestation the fetal weight was significantly lower in AcD+saline group or in Msp+saline group than control group (control 4.42g, AcD+saline group 3.91g, Msp+saline group 3.21g), and markedly recovered by Th administration (AcD+Th group 4.41g, Msp+Th group 3.66g).
2) Compaired weth controls, IUGR rats had a poor placental blood flow (control 0.89 ml/min, AcD+saline group 0.63 ml/min, Msp+saline group 0.38 ml/min, P<0.001), and had the significant recoveries of that blood flow by Th administration (AcD+Th group 0.99ml/ min, Msp+Th group 0.53ml/min, P<0.001).
3) Placental c-AMP was significantly lower (P<0.05) in AcD+saline group (204±53p moles/mg protein) compaired with normal pregnancy (316±68p moles) and recovered to 255±34p moles in AcD+Th group.
4) Spontaneous uteine contraction was inhibited at the5×10-3mg/ml or more of Thadministration.
5) Via placental maternal transport of 3H-glucose and 14C-α-aminoisobutyric acid (AIB) was lower in AcD+saline group (19.1%, 21.5%) than normal control group.
Recovery rates of these transport in Th series were 13.5%, 16.5% in AcD+Th group.
6) Aminophylline (250mg, 10minutes) was infused venously to 6 pregnant women at 3rd trimester, and 7 women at delivery. Fetal heart function was increased in rate and in varia bility but maternal heart rate and blood pressure had no change.
These data suggested that Th is useful drug for the treatment of IUGR pregnancy.View full abstractDownload PDF (3571K) -
Hideaki IIOKA, Ikuko MORIYAMA, Motohiko ICHIJO1984 Volume 36 Issue 6 Pages 595-602
Published: November 01, 1984
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSUsing microvilli (brush border) vesicles prepared from human term placenta the uptake of L-alanine was studied using rapid filtration technique. The uptake of L-alanine into the vesicles was osmotically sensitive.
A Na+ electrochemical gradient (extravesicular>intravesicular) stimulated the initial rate of L-alanine uptake and the Na+ dependent uptake of L-alanine into vesicles shows a typical overshoot phenomenon. This overshoot and the initial rate of uptake are markedly increased when the intravesicular space is rendered electrically more negative by membrane diffusion potentials, induced by the use of highly permeant anions. A similar stimulation of L-alanine uptake was observed, when membrane potential (inside negative) was imposed by K+ diffusion potentials via valinomycin.
These results indicated that a sodium dependent uptake of L-alanine into the microvilli membrane vesicles is dependent on the electrical potential difference of membrane.View full abstractDownload PDF (689K) -
Masafumi ITOH, Ichiro KITAGAWA, Takara YAMAMOTO, Hiroji OKADA1984 Volume 36 Issue 6 Pages 603-610
Published: November 01, 1984
Released on J-STAGE: December 02, 2011
JOURNAL FREE ACCESSWe treated a 48-year-old woman with multiple metastasis of gestational choriocarcinoma by the use of large dose of methotrexate (MTX) and the rescue by citrovorum factors. The metastasis was extended to lung and liver after the resection of uterine tumor and brain tumor. Dose of MTX (®Methotrexate Inj) was proceeded at 20-100mg per kg of the patients body weigh with the intravenous drip infusion. After its drip infusion, the damage of normal cells was rescued by citrovorum factors (®Leucovorin Inj) under monitoring MTX concentration in serum. The chemotherapy was beyond 5 months (5/23/82-10/12/82) and total doses of MTX was reached to 21, 600mg.
As the result of chemotherapy, the size and the number of hepatic tumor was remarkably reduced. However, pulmonary tumor was uneffective for this therapy and its size was increased during the therapy. Side effects which resulted in the therapy, did not almost appear and the patient was in good condition during the course.
Clinical course for the patient was presented here.View full abstractDownload PDF (5245K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1984 Volume 36 Issue 6 Pages 611-613
Published: November 01, 1984
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESS
- |<
- <
- 1
- >
- >|