All issues
Volume 44 (1992)
- Issue 6 Pages 581-
- Issue 5 Pages 475-
- Issue 4 Pages 351-
- Issue 3 Pages 239-
- Issue 2 Pages 143-
- Issue 1 Pages 1-
Volume 44, Issue 3
Displaying 1-5 of 5 articles from this issue
- |<
- <
- 1
- >
- >|
-
Yukitoshi YAMAGUCHI, Tetsuo OTANI, Matsuto MOCHIZUKI1992 Volume 44 Issue 3 Pages 239-244
Published: 1992
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSPlacental alkaline phosphatase (P-ALP) is a glycoprotein hormore expressed mainly in term placenta. However, there are many obscurities about its physiological action. Here, we analyzed the control mechanism of P-ALP expression utilizing molecular biological methods.
First, to detect attitude of P-ALP expression in trophoblastic tissue, we examined expression of this protein at transcriptional level by hybridization utilizing P-ALP specific cDNA probe. Then we studied the relationship between morphology of cultured trophoblastic cells and P-ALP secretion pattern, utilizing cytotrophoblast culture system. Next, we studied effect of toxemia of pregnancy and IUGR (intrauterine growth retardation) on P-ALP mRNA expression. Last of all, we studied the serum P-ALP level during the course of normal pregnancy.
The result of these studies indicated that P-ALP gene expression is controlled at transcriptional level and the expression needs a process which involves changes in morphology from mononuclear cytotrophoblast to multinuclear syncytiotrophoblast like cells. Both serum protein and mRNA of P-ALP is detected in trophoblasts obtained from eaerly pregnancy at lower level and the expression increase as pregnancy proceeds. Not much difference of P-ALP expression was found between normal term pregrancy, toxemia of pregnancy or IUGR due to large difference in P-ALP expression among individual cases.View full abstractDownload PDF (7179K) -
Tatsuji HOSHINO, Eise TAKASHIMA, Yoshiyuki ONO, Masafumi NONOGAKI, Ich ...1992 Volume 44 Issue 3 Pages 245-251
Published: 1992
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSWe report clinical history, cytological findings, colposcopic findings and pathohistological findings in a case of adenoma maligum.
Adenoma malignum (minimal deviation adenocarcinoma) is classified as adenocarcinoma, endocervical type, well-differentiated in the “General rules for clinical and pathological management of uterine cervical cancer”.
The adenoma malignum was characterized by long clinical history of profuse muco-serous vaginal discharge, cytological findings of a large conglomerated cluster with irregularly enriched cytoplasm (some cells were large and mucinous while others were small and compressed against neighboring cells), colposcopic findings of atypical vessels and large glandular opening in rough-surfaced, atypical transformation zones, and pathohistological findings of proliferating grands of varying size containing cells with enriched cytoplasma and almost normal small basal nuclei.View full abstractDownload PDF (8025K) -
Kozo ITO1992 Volume 44 Issue 3 Pages 252-257
Published: 1992
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSAs a result of clinical and pathological studies, it has been shown that mixed mesodermal tumor (MMT) has a poor prognosis compared with endometrial carcinoma, and occurs predominantly in elderly women. Because of the rapidity of proliferation of this tumor, its early invasion into the lymphatics and blood vessels, and the likelihood of both lymph node and hematogenous metastases, early diagnosis and early treatment are particularly important. In the investigation of MMT, endometrial cytodiagnosis is essential, but it is quite difficult to diagnose the tumor correctly before surgery. For early diagnosis, the most effective current mean seems to be a cytodiagnosis.
In the present study on cytodiagnosis of this tumor, the characteristics of the rhabdomyosarcoma component of MMT were investigated and the following findings were obtained.
An important point in the cytodiagnosis of this tumor is the simultaneous detection of malignant epithelial cells and non-epithelial cells, but since detection of MMT cells tends to be determined by the extent of proliferation of the lesion, the epithelial malignant component is actually more likely to be detected, as reported previously. In the epithelial component, adenocarcinoma cells are apt to apper. On the other hand, in the non-epithelial component, cells with a wide variety of features and some similarities appear, and utmost caution seems to be required against their differentiation. However, when rhabdomyosarcoma cells appear, their features are characteristic and easy to distinguish. The features of these cells are as follows.
The cells which appear independently and sporadically, are relatively large in size, and have a polyhedral band form. The cell margins are rather unclear and the cytoplasm is generally stained with a light green color, there are some pale red eosinophilic areas and the staining is non-uniform. The nuclei are swollen and elliptical, the chromation is densely stained in a coarse granular pattern, the nuclear margins are expanded, and the N/C ratio is high. This type of cell has abundant cytoplasm and is shaped like a tadpole, having amoeboid protrusions.The cytoplasm is light green and is filled with granules of various sizes, being nonuiform and heavy in its staining characteristics. The chromatin shows coarse granulation, and a large red nucleolus is found therein.View full abstractDownload PDF (6104K) -
a case reportYoshinori NAKATA, Masakazu YOKOZEKI, Kiyoyuki HARADA, Toshio YAMADA, M ...1992 Volume 44 Issue 3 Pages 258-262
Published: 1992
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSIn a 34-year-old woman (gravida 1, para 0) left tubal pregnancy was diagnosed prior to rupture at 8 weeks' gestation by transvaginal ultrasound tomography. She was treated with conservative surgery by carbon dioxide laser salpingostomy of the left fallopian tube. The antimesosalpingeal border was injected with an epinephrin solution, and a 1-cm linear salpingostomy incision was made. The intratubal contents were removed and the incision was closed with 4-0 nylon sutures. Her postoperative hospital course was uncomplicated. A postoperative hysterosalpingogram postoperatively showed patency in the surgically treated tube.View full abstractDownload PDF (5274K) -
Yuichiro NAKAI, Yoshihiko MIYAZAKI, Yasunaga MATSUOKA, Yoshikiyo OSAWA ...1992 Volume 44 Issue 3 Pages 263-266
Published: 1992
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSInterstitial pregnancy is a rare type of ectopic pregnancy. Diagnosis before rupture by transabdominal ultrasonography is difficult, and the laparoscopy or hysteroscopy has been used for the diagnosis of unruptured interstitial pregnancy. However, laparoscopy requires general anesthesia, and hysteroscopy has risks for the fetus if the pregnancy is normal. Transvaginal approach of ultrasonography can image the internal reproductive organs better than the transabdominal approach. We were able to diagnose an unruptured interstitial pregnancy by this method.
A 34-year-old para-0, gravida-2 woman reported amenorrhea and pregnancy of 6 weeks was diagnosed. However, no gestational sac was seen in the uterine cavity and an endometrial echo was detected by transabdominal ultrasonography.
In the 7th gestational week, a gestatoinal sac was seen in the right wall of the uterus, but an endometrial echo was also observed by transvaginal ultrasonography. Interstitial pregnancy was diagnosed.
Severe lower abdominal pain occurred in the 11th gestational week. We diagnosed threatened rupture of the interstitial pregnancy and confirmed it by laparotomy.
We conclude that an unruptured interstitial pregnancy can be diagnosed when a gestational sac is seen in the wall of the uterus, and endometrial echo is observed by transvaginal ultrasonography.View full abstractDownload PDF (5297K)
- |<
- <
- 1
- >
- >|