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Volume 13 (1972)
- Issue 6 Pages 923-
- Issue 5 Pages 769-
- Issue 4 Pages 455-
- Issue 3 Pages 249-
- Issue 2 Pages 105-
- Issue 1 Pages 1-
Volume 13, Issue 5
Displaying 1-20 of 20 articles from this issue
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Akira B. MIURA, Akira SHIBATA, Tetsuo AKIHAMA, Yasuyuki ENDO, Katsuko ...1972 Volume 13 Issue 5 Pages 769-776
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (764K)
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T. MIYAZAKI, T. ISHIZAKI, I. MAEKAWA, H. SANO, K. IDAKA, T. SHIRAISHI, ...1972 Volume 13 Issue 5 Pages 777-786
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSPipobroman [N, N'-bis-(3-bromopropionyl) piperazine] was orally administered to 8 patients with polycythemia vera once a day for 7 to 71 weeks. Firstly, 0.5 mg/kg/day of Pipobroman were administered to 3 cases, 1.0 mg/kg/day to 4 and 1.5 mg/kg/day to one.
Complete remission was observed in 3 cases of them, the partial remission in 2 and the hematological improvement in one case. One of two remainders did not respond well to Pipobroman, possibly due to the insufficient period of treatment, while the other develeoped hypoplastic anemia, in whom the dose had been increased up to 2.5 mg/kg/day in order to get the further effect on the clinical and hematological state. For one relapsed case, 0.5 mg/kg/day was administered with partial remission. Another one case with the maintainance dose of 0.38 mg/kg/day has been administered up to now for about 71 weeks, holding the complete remisson for these 6 months.
Slight degree of leukopenia was observed in some of the patients. However, no serious side-effects were not recognized.
From these results, it is concluded that the effect of Pipobroman on polycythemia vera is able to be expected as same as that of Myleran. As to the dose of Pipobroman, 0.5 mg/kg/day should be administered firstly, thereafter, if necessary, 0.25 mg/kg/day could be added to the initial dose. Further, 0.1-0.5 mg/kg/day would be favourably recommended as a maintainance dose in order to prevent the relapse and hold the remission as long as possible.View full abstractDownload PDF (802K) -
—in vitro measurement using 75Se-selenomethionine—Makoto HASEGAWA, Hiroo YOSHIOKA, Shigeru ARIMORI, Ichiro IWASAKI1972 Volume 13 Issue 5 Pages 787-792
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSHuman peripheral lymphocytes were cultured for 96 hours in the medium added 75Se-selenomethionine. Incorporation of 75Se-selenomethionine into globulin was assayed by well type scintillation counter. Phytohemagglutinin (PHA) reactivity of lymphocytes was represented as the ratio of the PHA stimulated lymphocytes to that of the unstimulated ones. The lymphocytes of healthy adult were stimulated by PHA and globulin synthesis was activated. But PHA reactivity of lymphocytes was suppressed in the patients with Hodgkin's disease, CLL, SLE, dermatomyositis, autoimmune hemolytic anemia, uremia, infectious mononucleosis and hypoplastic anemia.View full abstractDownload PDF (428K) -
Eiko OHTA, Yutaka MIURA, Yoshio TOZAWA1972 Volume 13 Issue 5 Pages 793-799
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe fibrin plate method by Astrup and Mullertz (1952) is a typical one among the methods for measuring fibrinolytic activities.
A new method of the authors in which agar gel was used as a support in fibrin plate was named “Fibrin-Agar-Plate (F.A.P.)” method.
The principle of the F.A.P. method is the same as that of the fibrin plate method and the procedures are similar to those in radial immunodiffusion method.
F.A.P. was prepared in Petri dishes (9 cm in diameter) in a following way: Seven ml of a 2 per cent agar solution (Difco) was mixed with 3 ml of an aqueous solution containing 8 mg of fibrinogen at 40 to 50°C (final concentration of agar was 1.4% and that of fibrinogen 0.08%, pH. 7.8). When the agar-fibrinogen mixture has solidified at room temperature, 1.5 ml (5 units) of thrombin solution was added. Afilter paper (8.6 cm diameter) was placed on it so that the surface of the agar plate became uniformly wet. It was allowed to stand at 4°C for not less than 5 hours. Then the filter paper was taken off and the holes with a diameter of 2 mm were punched out, samples (2 μl) poured in and the plates were kept at 37°C for 18 hours. The size of the zone of lysis was taken as a measure of fibrinolytic activity.
Unlike fibrin plate method, the F.A.P. method requires neither a wide horizontal laboratory desk nor skill. The zones of lysis produced show a sharp contrast with the fibrin substrate and were almost always circular.
The F.A.P. method is reproducible and a close correlation with fibrin plate method has been obtained.View full abstractDownload PDF (562K) -
Kotaro YAMAOKA, Yoshiro OHTA, Masashi SEITA1972 Volume 13 Issue 5 Pages 800-804
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe present paper is concerned with a method of thin layer starch gel electrophoresis modifying the method of Baur. Characteristics and advantages of this method are the following: (1) proteins are clearly separable by means of a relatively simple technique, and (2) many samples are at the same time analyzed only for two hours.
Two square glass plates (size 20×20 cm) are prepared as a pair, one of which is fraund with vinyl tape of 2 mm thickness for the square and another is used as the cover.
Gel preparation buffer (pH 8.6) is 0.9 M tris (hydroxymethyl) aminomethane, 0.02 M EDTA and 0.5 M boric acid as a stock solution. This stock solution is diluted 15 times with water before use. The electrode buffer (pH 8.6) is 0.18 M boric acid and 0.08 M sodium metaborate.
Ten gm of hydrolysed starch (Connaught Laboratories) is mixed with 60 ml of gel preparation buffer.
Concentrations of hemolysate, serum and urine are approximately 10 gm/dl, 7 gm/dl, and 2—6 gm/dl, respectively.
Electrophoresis was performed 250 volts/20 cm for 2 hours and stained with amido black 10 B. Using electrophoresis of this system for screening of abnormal hemoglobins, we have detected 22 abnormal hemoglobins and 6 thalassemias among 60,000 blood specimens in Western Japan.View full abstractDownload PDF (486K) -
Analysis of 64 Autopsy Cases and Report on the Prophylactic Effect of Oral Antibiotic Combination Regimen.Yasusuke ONOZAWA, Shimpei FURUSAWA, Yamao ADACHI, Heihachiro KASHIWAGI ...1972 Volume 13 Issue 5 Pages 805-810
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe incidence of disseminated and deep mycotic infections was investigated in 64 autopsy cases with disorders of the hematopoietic tissue experienced in the past 5 years. The overall incidence of fungal infections was 45%. The average incidence among patients with acute leukemia was similar to that found in patients with non-leukemic diseases including malignant lymphoma, aplastic anemia, multiple myeloma, etc. Candida albicans and Aspergillus dominated the major pathogenic fungal strains followed by Mucor and Cryptococcus. Fungi were identified most frequently in the lung and digestive tract. The incidence of these mycotic infections and severe bacterial infections was strikingly high among patients whose circulating neutrophil counts within a week before demise were below 500/mm3. Ulceration, erosion and necrotic changes in the gastrointestinal mucosa were also common in severely neutropenic patients.
In a separate study, 10 hospitalized patients with acute leukemia were given an oral regimen of the combination of gentamycin sulfate 600 mg, amphotericin B 2000 mg and kanamycin 2000 mg daily divided in 4 doses while they were neutropenic below 500/mm3. Only well-cooked diet was offered to these patients while they were given this oral antibiotic regimen. Serial fungal colony counts of feces of these patients revealed that the growth of fungi in feces was clearly suppressed while the patients were under this antibiotic regimen. There was no evidence of clinically apparent mycotic infections in these patients during the study.
Seven of the 10 patients underwent complete or incomplete hematological remission while the remaining 3 died during the hospitalization without achieving remission from anti-leukemic chemotherapy. The direct causes of death in these 3 mortalities were Pseudomonas septicemia, hemorrhage and probable bacterial infection, respectively. A single incidence of nausea was observed during the therapy. The combination of gentamycin sulfate, amphotericin B and kanamycin by oral route appears to be a useful adjunct to the anti-leukemic therapy of patients whose resistance against mycotic and bacterial infections is at harzard from severe neutropenia.View full abstractDownload PDF (515K) -
Hiroshi OHTA, Yasushi IKEDA, Toshihiko SHIBATA, Hiromi HATTORI, Akiyas ...1972 Volume 13 Issue 5 Pages 811-819
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSEffect of melphalan in the treatment of myelomatosis was studied in 17 case with this disorder out of 25 cases given melphalan during 4 year period.
Six to 10 mg melphalan per day was administered for 7 days as an initial loading dose, followed by maintenance therapy with 2 mg daily after the pause to get the recovery of leukocyte count. Therapy with intermittent large doses was given in a few cases.
With a criteria for improvement such as decrease in serum M-component or Bence Jones protein excretion in urine less than 50% of the intial values, decrement of diameter of tumor to less than half of the pretreatment size and disappearance of pain, excellent response to melphalan therapy was obtained in 5 cases, and good response in 6 cases, while 6 patients did not respond to melphalan. Pain relief was the most remarkable effect in responsive cases. The 50% survival of responders was 30.0 months in contrast to 16.5 months in non-responders. There was no significant difference found in the rate of response among patients with different classes of Heavy chain or different types of Light chain of abnormal serum or Bence Jones protein.
Melphalan is considered as the first choice drug for myelomatosis if it is administered under careful observation of patient's hematologic status.View full abstractDownload PDF (753K) -
Noboru MATSUMOTO, Hideki OYAMA, Moichi MATSUMURA, Nobumasa SUETSUGU, S ...1972 Volume 13 Issue 5 Pages 820-826
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSProcarbazine (Natulan) was administered to four patients with malignant lymphoma (2 cases with Hodgkin's disease and 2 cases with reticulum cell sarcoma) with combination of radiation, alkylating agents, Vinca alkaloids, Bleomycin or prednisolone. Significant responses were observed in two patients with Hodgkin's disease and in one of two cases with reticulum cell sarcoma. In a patient with Hodgkin's disease, who had been previously treated with radiation, Vinca alkaloids and alkylating agent, combination of procarbazine with radiation and Vinblastin was effective to induce remission again. It was suggested that procarbazine had no cross-resistance with these agents.
As side effects of procarbazine, pancytopenia was noted in all cases, but myelosuppression was gradually improved after cessation of administration. Significant toxic effects to the liver and kidney were not observed.
Combination of procarbazine with radiation or other anti-tumorous agents seems to be effective for the management of advanced cases with malignant lymphoma.View full abstractDownload PDF (575K) -
Hiroshi SAITO1972 Volume 13 Issue 5 Pages 827-830
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSIron absorption of the patients with iron deficiency anemia was determined with a whole-body counter after the administration of 2 iron tablets contating 100 mg of iron and radioiron in the form of ferrous sulfate and compared with that of the normal control. The whole-body distribution of radioiron was demonstrated by linear scanning at intervals after the oral administration of the drug. This showed a slow decomposition of the tablets and iron absorption.
The total amount of absorption of iron with 100 mg of carrier was 13 times higher than that with 4 mg of carrier in normal. Iron absorption in patients with iron deficiency anemia was sufficiently high and a good effect of the oral iron therapy was expected. No side-effect was observed in the present study with 100 mg dose.View full abstractDownload PDF (269K) -
Tamotsu MATSUDA, Mototaka MURAKAMI1972 Volume 13 Issue 5 Pages 831-834
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESS1. Effects of hydroxyethyl starch on blood coagulation and fibrinolysis were compared to those of dextrans.
The average molecular weight of hyproxyethyl starch was in the range from 30,000 to 40,000, and the degree of substitution was 0.55. The average molecular weights of two different types of dextrans used in this investigation were 40,000 and 70,000, respectively.
2. In vitro experiments revealed that the addition of hydroxyethyl starch or dextran to plasma resulted in accerelation of thrombin time, while there were no significant changes in partial thromboplastin time, prothrombin time, euglobulin lysis time and caseinolytic activity of plasma activated by streptokinase.View full abstractDownload PDF (284K)
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Minoru HAMAZAKI, Hideaki NISHI, Hitoshi KAMIYA, Michio TAKI, Minoru SA ...1972 Volume 13 Issue 5 Pages 835-843
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA systemic and neoplastic proliferation of the primitive reticular cells or their derivatives is often termed malignant reticulosis, malignant reticuloendotheliosis or malignant reticulohistiocytosis. Because of rarity and variability of the clinical picture in this disease, no distinct clinical and pathological concept of this entity has been given.
We have reported 3 different types of so-called malignant reticulosis, which took a rapid fatal course.
The first case was a 6 year old boy, who developed a remittent fever, and hepatosplenomegaly one month prior to admission. Atypical primitive reticular cells were seen in the peripheral blood and bone marrow smears. Histologically, the bone marrow, liver, spleen and lymph nodes were mainly involved. The morphologically malignant reticular cells were infiltrated difusely, without producing tumor, and often, the cells phagocitized red blood cells. From these findings, this case might be categolized into leukemic reticulosis.
The 2nd case was a one year and 2 month old female with Letterer-Siwe's disease, in which infiltration of the more differentiated reticulum cells was observed. The 3rd case was mostly considered as a malignant reticulosis due to clinical findings but autopsy was not performed.View full abstractDownload PDF (922K) -
Hirobumi KONDO, Masahiro HOSHIDA, Akira KAWAMURA1972 Volume 13 Issue 5 Pages 844-849
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 23-year-old house wife on the 7 th month of gestation was admitted to the Ichikawa Hospital on July 22, complaining of severe gingival bleeding since the end of June. Physical examination revealed marked anemia and ecchymoses. Atypical promyelocytes were 84% of peripheral WBC and 88.4% of bone marrow cells. Normal ESR, thrombocytopenia, hypofibrinogenemia and reduced coagulation factors were observed. but hyperfibrinolysis was not present and ethanol gel test was positive. Leukemic cells lysed the fibrin plate markedly.
The patient was treated under diagnosis of acute promyelocytic leukemia, but on the 26 th hospital day the disappearance of the fetal heart sound was noticed in the morning, and the patient died in the evening of the same day. Autopsy revealed proliferation of atypical promyelocytes, marked bleeding in several organs and bilateral renal cortical necrosis with fibrin thrombi in the glomerular capillaries.
The pathogenesis of the marked hemorrhagic tendency with the hypofibrinogenemia in this case was considered to be mainly the intravascular coagulation which had, been reported in some cases of promyelocytic leukemia. In addition to the promyelocytic leukemia, pregnancy and fatal death might also have participated in this phenomenon.View full abstractDownload PDF (605K) -
Atsuo SUZUKI, Akiyuki YAMADA, Haruyo MARUYAMA1972 Volume 13 Issue 5 Pages 850-854
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThis is a case report of a 27 year old woman who had an acute hemolytic anemia accompanied by severe hemoglobinuria resulting in acute renal failure, probably due to Clostridium perfrigens A septicemia following artificial abortion at 13 weeks' gestation. The septicemia and hemolysis were succesfully treated by cephalocin and corticosteroid, but peritoneal dialysis of 12 days' duration was required for recovery from acute renal failure.
As hematological findings, in addition to severe anemia, leucocytosis accompanied by “the shift to the left” of neutrophils, reticulocytosis, extreme enhancement of osmotic fragillity of red cells, peripheral blood smear showed remarkable spherocytosis as outstanding finding which disappeared when the patient recovered.View full abstractDownload PDF (534K) -
—Report of One Family Study and Review of Japanese Literature—Takeo ONISHI, Yasunari NAKATA, Shigeru ARIMORI1972 Volume 13 Issue 5 Pages 855-863
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA sixty-year old man presented himself with a chief complaint of upper abdominal pain which was subsequently found to be due to ascariasis and cleared completely after anthelmintic therapy. Incidental blood study showed normochromic anemia with large numbers of elliptocytary red blood cells. According to Günther's criteria, erythrocytes were classified into four different types and a percentage of each type in the patient was determined. The results were that type I (round) was 0%, type II (oval) 2.5%, type III (elliptical) 1.5% and type IV (rod shaped) 96.0% respectively. In spite of very meticulous observation on the shape of erythroblasts in varying stages of development, no significant changes were noted in the sternal marrow aspirate. Reticulocytes in the peripheral blood were all round in shape.
A total of thirteen of the fourteen members of this family were evaluated through 3 generations, and six were found to have positive elliptocytes. The mode of inheritance in these six kindreds could be explained as a simple or autosomal dominant.
In 1904, for the first time in the world, Dresbach reported one case of elliptocytosis. In Japan, it was in 1938 when the first case was described by Iwao. Since then, forty-two families with this hereditary disease were reported with a totaling number of 152 patients. Symptomatic or transient elliptical erythrocytosis was described in other four reports and another report was concerned with the degrees of elliptical changes seen in normol human erythrocytes.View full abstractDownload PDF (813K) -
Yasushi IKEDA, Hiroshi OHTA, Takeaki TAKENAKA, Junya TAKAHASHI, Senich ...1972 Volume 13 Issue 5 Pages 864-872
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA case of primary macroglobulinemia with apparent punched out bone lesions in skull and femur is reported.
The patient, 72 year-old female, was admitted to the Meijo Hospital because of severe lumbago and anemia. She developed bleeding manifestations such as melena, genital bleeding and retinal hemmorhage possibly due to thrombocytopenia. X-ray examination of bones disclosed definite punched out lesions in skull and femur and generalized osteoporosis. M-component found by electrophoresis on cellulose acetate membrane was identified as macroglobulin by immunoelectrophoresis. Levels of the macroglobulin with sedimentation constant of 16.7 S ranged from 900 to 1,300 mg/dl during the course of her disease. Relative viscosity of serum was within normal range.
Plasma cells constituted more than 80% of the total bone marrow cells and plasmacytoid lymphocytes were occasionally found especially at terminal stage. Tumor cells possessed an ovoid or rounded and peripherally displaced nucleus, exhibited abundant cytoplasm rich in endoplasmic reticulum, and had a prominent Golgi area. She died 15 months after the onset of the disease, and the infiltration of plasma cells to bones including sternum, thoracic and lumbar vertebrae and ileum as well as kidney, liver, pancreas, spleen and adrenal cortex was shown by autopsy.
Based on these findings, myelomatous macroglobulinemia was proposed as a rare form of primary macroglobulinemia.View full abstractDownload PDF (2253K) -
Shoichi MATSUMOTO, Takayuki IWANAGA, Osamu HIGO, Atsushi HORIUCHI, Kaz ...1972 Volume 13 Issue 5 Pages 873-878
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThe patient was a 15-year-old female who had complained the anemia and lymph node swelling on April, 1966. She was admitted to our hospital on September 13, 1966. Peripheral WBC was 32,700 with 92% of leukemia cells (93.5% in bone marrow cells), and Auer body was positive.
A complete remission was obtained by 6MP treatment for three months, and was maintained for one year.
On the second admission on November 25, 1967, remission was induced with methotrexate. After seven months, peripheral WBC was 6800 with 45% of leukemic cells (52% in bone marrow cells). But cytoxan was ineffective.
On the third admission on October 16, 1968, she was treated with 6MP and cytosine arabinoside, and the complete remission was obtained after one month. Subsequently she kept the remission for three months by the subcutaneous injection of cytosine arabinoside. Though the leukemic cells occupied 58.4% of the bone marrow cells, vincristine was not effective thereafter.
Daunomycin was administrated in the fourth adimission on August 18, 1969. But the remission did not occurred. She died on October 11, 1969.View full abstractDownload PDF (545K) -
Tetsuo AKIHAMA, Akira SHIBATA, Akira MIURA, Yasuyuki ENDO, Tsuyoshi MU ...1972 Volume 13 Issue 5 Pages 879-884
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSHere described 73-year-old woman who had showed remarkable hemorrhagic diathesis for a few months. The color of her skin was dark reddish and mucous membrane ruddy and cyanotic. Subcutaneous hemorrhage was observed on the anterior chest and forearms. Peripheral blood examination revealed pancythemia, particularly erythrocytosis.
Hematological findings disclosed red-blood cells 8,070,000, hemoglobin 16.8 gm/100 ml., hematocrit 54.9%, white-blood cells 16,100 and thrombocytes 322,000.
She was diagnosed polycythemia vera from physical signs and laboratory findings. Coagulation study was performed because her remarkable hemorrhagic diathesis in spite of thrombocythemia. Except the positive tourdiquet test and low plasma fibrinogen we could not detect a deficiency of coagulation factors nor accelerated fibrinolysis. The hemorrhagic mechanism in this case may chiefly concern with the hemodynamics and the fragility of perivascular tissues. Lysozyme (Muramidase) activity in her serum and urine was elevated compared with control group. These findings may suggest that not only erythropoiesis but granulopoiesis may elevated in polycythemia vera.View full abstractDownload PDF (458K) -
Koh SUGAWARA, Tadashi AIZAWA, Kazuo TAKASHINA, Setsuko KAWAMURA, Yutak ...1972 Volume 13 Issue 5 Pages 885-891
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 42 aged male who had an onset of speech disturbance and was diagnosed as cerebral thrombosis in Sept., 1970, was found to have hypertension and polycythemia. Ten months later, he was refered to our clinic for a thorough examination of erythrocytosis.
Physical examination on admission revealed a soft, uneven, palm-sized tumor palpable in the right abdomen. Liver and spleen were not palpable. Hematological examination showed RBC 6.8 million, Hb 19.8gm/dl, Ht 61%, WBC 5000, pl. 270×103. Bone marrow aspirate showed an increased erythroblasts but no atypical cells. Liver function tests and electrolytes values were within normal limits. Total red cell volume (TRCV) and erythropoietin activity in urine (59Fe-uptake method in starveted rats) were markedly increased.
On plain x-ray film multiple small calcified shadows were found in the right abdomen. Intravenous and retrograde pyelogram, aortogram, selective renal angiogram and renogram suggested a right giant renal tumor probably due to obstructive nephropathy.
The right extirpated kidney was 27×16×9 cm. in size and weighed 2000 gm. The pelves were occupied with caseous mass, and consequently the renal parenchyma was atrophied. The preoperative diagnosis of tuberculous pyonephrosis was confirmed.
Three weeks after nephrectomy the blood counts were RBC 5.2 million, Hb 16.1 gm/dl, Ht 47%. The TRCV was 47.6ml/kg, and erythropoietin activity in urine was markedly decreased. Three months later, the hematological findings were still within normal limits, and no tendency of erythrocytosis was seen.View full abstractDownload PDF (683K) -
Ichiro TSUKIMOTO, Michio HOSHINO, Myota MIURA1972 Volume 13 Issue 5 Pages 892-898
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSThree young infants with consumption coagulopathy are presented. All cases were admitted as emergency cases of severe bleeding, as chief complaint. Coagulation studies and postmortem examination was performed.
Case 1: One month old girl who died of necrotizing enterocolitis 2 days after admission.
Case 2: Four months old girl who died of pneumococcal sepsis 12 hours after admission.
Case 3: A premature infant who died of intracranial hemorrhage and pulmonary hemorrhage at 24 hours of age.
The coagulation studies of all cases revealed decreased platelet counts and prolonged bleeding time, coagulation time, prothrombin time and partial thromboplastin time. Fibrinogen was decreased in only one case. (Case 3).
Postmortem examination was performed on all cases, and two of them had microthrombi in the glomeluli (case 1, 2), and one of them had severe pulmonary and intracranial hemorrhage. (case 3).View full abstractDownload PDF (620K) -
Michiro Go, Yoshihiko KOMATSU, Asano KIMURA, Setsuko KAWAMURA, Yutaka ...1972 Volume 13 Issue 5 Pages 899-903
Published: 1972
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 14 old male who became icteric after fever and diarrhea was diagnosed as having acute hepatitis in April, 1970. Although steroid hormone was instituted jaundice continued. Four months later serum γ-globulin was found to be low as 3%, and the patient was referred to our clinic for a thorough examination. Physical examination on admission revealed an icteric young male, and the liver was palpable three finger breadth beneath the right costal margin. Hematological examination showed: RBC 400×104, Hb 13.2 g/dl, WBC 6,000 and plasma clot time 89.2sec., all being within normal limits. Liver function tests at onset of jaundice were as follows: GOT 860 KU, GPT 890 KU, ZST 5.3 KU, bilirubin 20.5 mg/dl, alkaline phosphatase 26.0 KAU and total cholesterol 152 mg/dl, and those on admission to our clinic showed: GOT 173 KU, GPT 180 KU, ZST 0.6 KU, bilirubin 29.2 mg/dl, alkaline phosphatase 9.8 KAU and total cholesterol 245 mg/dl. ZST level was always low in our clinic, and so was γ-globulin. It was assumed that hypogammaglobulinemia was following acute hepatitis.
In October 1970, as liver functions became better, bleeding tendency occurred, and a marked decrease of the peripheral blood cells (RBC 152×104, WBC 1,100 and pletelet 16,000) developed. Bone marrow aspirate showed hypoplasia in all three elements and no plasma cell. Treatment was started with steroid hormone, protein anabolic hormone and fresh blood transfusion (total 8,230 ml.), and patient felt well by the end of Feb. 1971. In early May the Australian Antigen test became positive, and patient died of acute serum hepatitis in the middle of June. At autopsy the bone marrow was aplastic, and the liver weighed 1,120 gm. Chloramphenicol was not used all through the course.View full abstractDownload PDF (460K)
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