Objective: To image the olfactory nerve in vivo using single-photon emission computed tomography (SPECT) and X-ray computed tomography (CT) after nasal thallium-201 (
201Tl) administration to rats.
Methods: Three 8-week-old female Wistar rats (Japan SLC, Shizuoka, Japan) used in this study were assessed under anesthesia (intraperitoneal administration of pentobarbital sodium; 0.05 mg/g body weight) for
201Tl transport to the olfactory bulb 8h after nasal administration of
201TlCl solution (50μl, 74 MBq/ml, Nihon Medi-Physics, Tokyo, Japan) using SPECT/CT (Flex X-SPECT, Gamma Medica-Ideas, USA). The heads of rats were assessed for autoradiography to confirm
201Tl transport to the olfactory bulb after SPECT/CT.
Results:
201Tl transport to the olfactory bulb was shown using SPECT/CT 8h after nasal administration of
201Tl. Coronal section imaging especially indicated
201Tl transport from the nasal cavity to the olfactory bulb.
201Tl transport to the olfactory bulb was confirmed by autoradiography.
Conclusion: SPECT/CT showing
201Tl transport to the olfactory bulb may be useful in visually assessing the olfactory nerve
in vivo.
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