巻号一覧
74 巻, 5 号
選択された号の論文の5件中1～5を表示しています
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Men-dar WU, Masaru KIMURA, Shigeru INAFUKU, Hiromichi ISHIGAMI1997 年 74 巻 5 号 p. 155-165
発行日: 1997/12/22
公開日: 2012/09/24
ジャーナル フリーThe age-related induction of inducible nitric oxide synthase (iNOS) and apoptotic cell death in spiral ganglion cells (SGCs) of ddy strain mice were studied with immunohistochemical method and TdT-mediated dUTP-biotin nick end labeling (TUNEL), respectively. A large amount of iNOS was expressed in SGCs of 18- to 24-month-old mice, but not in those of the mice less than 12 months of age. Moreover, these mice were accompanied by a great rise in auditory brainstem response threshold as well as a great decrease in the number of SGCs that seemed to be due to preceding cell death of the cells. However, we were unable to find apoptotic TUNEL-positive cells in the spiral ganglions. This was assumed to be due to a very short clearance time of the dead cell bodies of less than one hour. As has been known, NO produced by iNOS can implicate in causes for either protection of cells from peroxidation and cell death. In the present study, therefore, the steep augmentation of iNOS in the SGCs of senescent mice implies that the iNOS initially induced to protect SGCs from the cytotoxicity of cellular peroxidation eventually contribute to the cell death of SGCs themselves.抄録全体を表示PDF形式でダウンロード (3461K) -
Bo LIU, Hidekazu WAKURI, Weitai YANG, Zhengguo YANG, Ken-ichiro MUTOH, ...1997 年 74 巻 5 号 p. 167-169
発行日: 1997/12/22
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (849K) -
Kazuyuki SHIMADA, Naotoshi TAKESHIGE, Hiroshi MORIYAMA, Yasushi MIYAUC ...1997 年 74 巻 5 号 p. 171-179
発行日: 1997/12/22
公開日: 2012/09/24
ジャーナル フリーIn this study, we clarified the distribution of elastic and oxytalan fibers in a human sternoclavicular joint (SCJ) using a color image system and in extracellular matrices using immunoperoxidase staining. Fine elastic fibers (EFs) were scattered in the fibrous layer of the sternoclavicular disk. This articular disk was composed of a collagenous bundle on the sternum side of the articular disk in the SCJ and cellular components including connective tissue on the clavicular side of the articular disk. The thickness of the disk gradually increased from the inferior to superior portion. Collagen fibers type I, III and V and other extracellular matrices (ECMs) were detected in the hypertrophic zone in the clavicular and sternum side of the SCJ and in the connective tissue of the articulatio condylar. On the cervical surface of the articular disk, cellular activity was higher than on the sternum surface.抄録全体を表示PDF形式でダウンロード (3247K) -
Effect of Sublethal X-irradiation on Follicular Trapping of Immune Complexes in the Mouse Lymph NodeDong CHEN, Hajime HOSHI, Kiyoshi TANAKA, Kaeko HORIE, Shin-ichi NEGISH ...1997 年 74 巻 5 号 p. 181-191
発行日: 1997/12/22
公開日: 2012/09/24
ジャーナル フリーIn one set of experiments, the effect of sublethal X-irradiation on the 24 h localization of subcutaneously injected immune complexes in the lymph node follicles was studied in mice which were given HRP-anti-HRP complexes into the rear footpad at 1-3 weeks after irradiation and killed I day later. The 24 h follicular localization of injected immune complexes in draining popliteal nodes was severely impaired at 7 days after irradiation, at which time residual follicles were markedly depleted of B lymphocytes. In following weeks, residual follicles began to be repopulated, and the 24 h follicular localization of immune complexes became restored. Follicular dendritic cells (FDC), as was detected by the in vitro trapping assay and/or by the immunostaining for complement receptors CR1, were present in lymph nodes at any time after irradiation. Another group of mice were given HRP-anti-HRP complexes at 6 days of X-irradiation and killed from 15 min to 24 h later. Following the injection, complexes localized in residual follicles in draining nodes within 15 min but soon diminished in density and finally disappeared by 24 h after injection. It is obvious that sublethal irradiation affect neither transport of immune complexes to lymph node follicles nor their localization in these follicles. Rather rapid disappearance after temporal localization of immune complexes in residual follicles in irradiated mice indicates that persisting FDC were unable effectively to trap immune complexes which were transported and localized in residual follicles. Ineffective trapping by FDC of immune complexes temporally localized in residual follicles is discussed in relation to the depletion of follicular B lymphocytes due to X-irradiation.抄録全体を表示PDF形式でダウンロード (2703K) -
Nobutsune ICHIHARA, Kiyoaki SASAKI, Sachi ISERI, Hirokazu KIMURA, Kosh ...1997 年 74 巻 5 号 p. 193-198
発行日: 1997/12/22
公開日: 2012/09/24
ジャーナル フリーImmunohistochemical localizations of carbonic anhydrase isozymes (CA-I, CA-II and CA-III) in bovine male reproductive tracts were studied. In bulls, no immunoreaction was seen after treatment with antibodies to CA-I, -II and CA-III in the testis. Specific staining for CA-III, however, was evident in peritubular cells in interstitial tissue of the testis, epididymis. CA-II activity could be detected in epithelium of the epididymis, ductus deferentis and ampulla ductus deferentis. Especially, a strong reaction for CA-II was seen in apical in epithelium of the epididymis in the initial and middle segment. CA-I activity was only founded in ductus deferentis and ampulla ductus deferentis. No or a weak reaction for CA-I, CA-II and CA-III were seen in the three accessory reproductive glands. Specific immunostaining for CA-II and CA-I could be observed in the organ, suggesting the bicarbonate in bovine semen to derive primarily from the genital tract and not accessory reproductive organs. CA-III-positive peritubular cells in interstitial tissue were also stained for alpha smooth muscle actin, and were very similar to contractile myofibroblast cells (Wrobel et al.,1979).抄録全体を表示PDF形式でダウンロード (1659K)
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