巻号一覧
83 巻 (2006)
- 4 号 p. 97-
- 3 号 p. 73-
- 2 号 p. 35-
- 1 号 p. 1-
83 巻, 1 号
選択された号の論文の5件中1～5を表示しています
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Hanayo OKAMOTO, Takanori MIKI, Kyoung-Youl LEE, Toshifumi YOKOYAMA, Hi ...2006 年 83 巻 1 号 p. 1-6
発行日: 2006年
公開日: 2008/01/12
ジャーナル フリーChronic ethanol consumption has adverse effects on the central nervous system. Hippocampus is one of the target sites of ethanol neurotoxicity. Hippocampal damage is known to result in impairment of learning and memory. This study was aimed to determine whether chronic ethanol consumption could alter the expression levels of brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) mRNAs in the hippocampus. Male Wistar rats were given unrestricted access to a liquid diet containing 5% (v/v) ethanol as the sole fluid source for 19 weeks beginning at 10 weeks of age. The expression levels of BDNF and GDNF mRNAs in the hippocampus were analyzed by real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis. The present study revealed that chronic ethanol consumption did not result in significant changes in the expression levels of BDNF and GDNF mRNAs. Our present results showed no significant alteration in the expression of these neurotrophic factors; these results will lead to further studies to examine the possible alterations in the gene expression of various neurotrophins that are related to hippocampal functions including learning and memory.抄録全体を表示PDF形式でダウンロード (102K) -
Junji ITO, Hiroshi MORIYAMA, Kazuyuki SHIMADA2006 年 83 巻 1 号 p. 7-14
発行日: 2006年
公開日: 2008/01/12
ジャーナル フリーThe facial muscles are composed ofstriated muscle fibers, as well as other skeletal muscles, and can produce more delicate and complex expressions. We studied 2 facial muscles of 10 Japanese cadavers (8 males and 2 females, average 74.7 years old) by histological techniques. We measured the cross-sectional area of the muscle belly (mm2), number ofmuscle fibers per mm2, total number ofmuscle fibers, and muscle fiber size (μm2). The depressor anguli orism. was predominant for the cross-sectional area and the total number of muscle fibers than other facial muscles. For the muscle fiber size, muscles inserted to the angle of the mouth were larger than those inserted to the lip. The orbicularis oculi and orbicularis oris muscles were the smallest facial muscles. The muscle fiber sizes in the facial muscles were less than other skeletal muscles.抄録全体を表示PDF形式でダウンロード (159K) -
Shiro FUJIWARA, Shunji KUMABE, Yasutomo IWAI2006 年 83 巻 1 号 p. 15-24
発行日: 2006年
公開日: 2008/01/12
ジャーナル フリーMany studies have been conducted on tissue stem cells in the field of regenerative medicine, and cultured dental pulp mesenchymal cells have been reported to secrete dentin matrix. in the present study we used alginate as a scaffold to transplant subcultured rat dental-pulp-derived cells subcutaneously into the back of nude mice. We found that when β-glycerophosphate was added to the culture medium, the mRNA of the dentin sialophosphoprotein (DSPP) gene coding dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) was expressed, and an increase in alkaline phosphatase, an early marker of odontoblast differentiation, was also demonstrated. Six weeks after implantation, subcutaneous formation of radiopaque calcified bodies was observed in situ. Immunohistochemical and fine structure studies identified expression of type I collagen, type III collagen, and DSP in the mineralizing transplants, and isolated odontoblast-like cells began to form dentin-like hard tissue formation. Scattered autolyzing apoptotic cells were also observed in the transplants. The study showed that subcultured rat dental-pulp-derived cells actively differentiate into odontoblast-like cells and induce calcification in an alginate scaffold.抄録全体を表示PDF形式でダウンロード (491K) -
Hiromi UEDA, Takuya MATSUKAWA, Takafumi WATANABE, Yoshinao HOSAKA, Kaz ...2006 年 83 巻 1 号 p. 25-32
発行日: 2006年
公開日: 2008/01/12
ジャーナル フリーThe cruciate ligament and the collateral ligament play key roles in stabilization of the knee joint. Cases of serious knee joint problems presented at the, the Veteimary Teaching Hospital of Rakuno Gakuen University, Japan mostly involved rupture of the cranial cruciate ligament (CCL). Disorders in structural and biochemical components of the CCL were thought to be the causes of the knee problems. Morphological, biochemical and biomechanical features of the CCL and the lateral collateral ligament (LCL) were therefore analyzed. in the CCL, fibroblasts with ovoid and enlarged nuclei were observed mainly at the periphery ofcollagen bundles. The array ofcollagen fibrils in the LCL was slightly disoriented, but that of the CCL was tight and regular. in the LCL, the major groups of collagen fibnls were those with diameters of 70-80 and 120-130 nm. Most collagen fibrils in the CCL had diameters of 70-80 nm. The mean collagen diameters were 90 nm in the CCL and 105 nm in the LCL. The ratios of the noncollagen area to the area occupied by collagen fibrils were 43% in the CCL and 55% in the LCL. There was no difference between the amounts of HA or between the amounts of DS in two ligaments. However, the amount of CS in the CCL was about 17-times greater than that in the LCL. The expansion of and the resistance to tension exerted onto the CCL were less than those of the LCL. A high concentration of CS and low tensile strength due to small-sized collagen fibrils cause the CCL to rupture easily, especially when overextension of the kneejoint occurs.抄録全体を表示PDF形式でダウンロード (254K) -
Re; Fibrous Connective Tissue between Müller's Muscle and the Palpebral Conjunctiva as a Reinforcement Structure and a Natural Barrier for the Upper EyelidHirohiko KAKIZAKI, Masahiro ZAKO, Takashi NAKANO, Ken ASAMOTO, Osamu M ...2006 年 83 巻 1 号 p. 33-34
発行日: 2006年
公開日: 2008/01/12
ジャーナル フリーPDF形式でダウンロード (28K)
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