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Volume 27 (1975)
- Issue 6 Pages 449-
- Issue 5 Pages 405-
- Issue 4 Pages 315-
- Issue 3 Pages 169-
- Issue 2 Pages 83-
- Issue 1 Pages 1-
Volume 27, Issue 5
Displaying 1-6 of 6 articles from this issue
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Katsuma UEDA, Hlroshi NAKAMORI, Hisao SAKO, Motokazu HAYASHI, Naohiko ...1975 Volume 27 Issue 5 Pages 405-411
Published: September 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSFrom the point of transplantation immunity a successful intrauterine graft of genetically alien tissue can never be explained without a peculiar mechanism in the mammalia.
The possible reason about the puzzling mechanism has been discussed by Medawar, Billingham and others. But almost all remains still unresolved.
One's attention might focus on the immunological antigenicity of the trophoblast when a pregnancy is discussed from the immunological aspect. So that, an immunogenicity of normal human trophoblast at early gestational stage was investigated by Mixed Leucocyte Trophoblast Interaction (MLTI) technique in vitro.
The results were as follows;
(1) The optimum conditions of MLTI were established.
(2) The response index of MLTI using trypsinized trophoblast and autochthonous leucocyte was 4.9.
(3) In the experiment with the addition of pregnant serum, the response index was decreased to 1.9.
(4) The antigenicity of trophoblast was increased twice degree when treated with trypsin solution.
From the above results, it was confirmed that human trophoblast has an antigenicity, of which liberation is depressed with masking substance covering trophoblastic cell surface and also with an inhibitory factor in pregnent serum in in situ.View full abstractDownload PDF (2044K) -
Katsuma UEDA, Hisao SAKO, Hiroshi NAKAMORI, Motokazu HAYASHI, Shigefus ...1975 Volume 27 Issue 5 Pages 413-418
Published: September 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSA mammalian pregnancy has been interpreted as an exceptionally homotransplant, because an embryo and its appendices might be recognized as a hybrid consisted of two different histoincompatible antigen. The possible reasons why a fetus is not immunologically rejected have been investigated from the point of view of cellular immunity. We have previously reported the characteristic maternal lymphocyte response to phytohemagglutinin using micro whole blood culture method and the peculiar alteration of the maternal lymphocyte activity was referred to the change in the absolute number of T-cells.
In this study, the inhibitory factor in pregnant serum on the T-cell function was examined. As a result, it was shown that pregnant serum has an inhibitory effect on the DNA synthesis of lymphocyte during gestational course and it increases following gestational stage and reaches it to maximum level at full term. Moreover, ovarian or uterine venous blood was collected to examine the distribution of inhibitory factor in pregnant serum;consequently high concentration of immunosuppressant was confirmed at the point of chorion-decidual junction comparing with systemic venous blood. As a conclusion, it was suggested that a high concentration of immunosuppressave factor in feto-maternal conflicting junction might play an important role as prevention from immunological rejection.View full abstractDownload PDF (814K) -
Kazutaka HAMADA, Yoshinobu HONDA, Motokazu HAYASHI, Katsuma UEDA, Tada ...1975 Volume 27 Issue 5 Pages 419-425
Published: September 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSTrophoblastic disease may be a model of tumor immunity because of its genetically allien tissue to the host. From this point of view, the host-tumor relationship must be considered in the treatment of trophoblastic disease. We followed up the cellular immune response of the host in two cases of choriocarcinoma with massive pulmonary metastases.
Cellular immune status was monitored by the following three points. 1) Absolute lymphocyte count in peripheral blood. 2) Percentage composition of small lymphocytes in heavier fraction (equivalent to 1, 066 to 1, 072). 3) Appearance rate of PHA-induced blastoid cell in heavier fraction.
Case 1-There was inverse relationship between the hCG titer and percentage composition of small lymphocyte and its blastoid cell in heavier fraction, but the latter kept under normal range constantly. This patient died of cerebral metastasis 12 months after admission.
Case 2-Above described three points monitoring immune status was retured to normal range with the recovery of clinical condition.
These results were suggestive that immunological monitoring might give us some information about prognosis and presumption of recurrence.View full abstractDownload PDF (4715K) -
Report of two Cases and Review of 13 Japanese Reported CasesMasato YAMASAKI, Gaiko UEDA, Yasuko SATO, Keizo HIRAMATSU, Keiichi KUR ...1975 Volume 27 Issue 5 Pages 427-432
Published: September 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSDysgerminoma ovarii associated with pregnancy is relatively rare. Two pregnant women with this neoplasm, both having stage 1A disease, are reported.
One patient, 21-year-old primigravida, was operated under the diagnosis of the twisted ovarian tumor at 17 weeks' gestation and was found to have a dysgerminoma of the left ovary. The patient was allowed to continue the pregnancy and gave birth of full term baby. She had two subsequent successful pregnancies and healthy 7 years later.
The other patient, 25-year-old primigravida, was operated under the diagnosis of the ovarian cyst at 7 weeks' gestation and was found to have a dysgerminoma of the right ovary. The patient gave birth of full term baby and without recurrence 3 months later.
However, immediate total hysterectomy and bilateral adnexectomies are recommended, if tumor is beyond stage 1A, or mixed or poorly differrentiated dysgerminoma.
Review of the Japanese literature revealed 13 reported cases of dysgerminoma associated with pregnancy. Our two case reports therefore brings the total of reported cases to 15.View full abstractDownload PDF (692K) -
—Changes in Vaginal Cytology and their Relation to Hormon Transition in Urine—Minoru UEKI, Ryo IKEDA, Takashi SANO, Katsuichi WATANABE, Osamu SUGIMO ...1975 Volume 27 Issue 5 Pages 433-439
Published: September 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSA case of 21-OH-lase deficiency non-salt losing type of congenital adrenal hyperplasia was diagnosed on the basis of endocrinological and other examinations.
Clitoridectomy was followed by glucocorticoid therapy, of which effect was evaluated by changes of the level of urinary 17-KS. Having some decrease of clinical symptoms and complete recovery of sexual function, the patient eventually married and became pregnant.
Vaginal smears taken before and periodically during the entire course of treatment sensitively reflected to alterations in the hormonal state. The androgen effect in vaginal cytology gradually disappeared with the treatment, replaced by estrinization. At the time of menarche, the vaginal smears showed normal female ones. Although ovulatory menstruation was induced, the cytology showed incomplete maturation unlike that in normal menstrual cycle. The maturation index closely coincided with changes in the urinary 17-KS and 17-OHCS levels.View full abstractDownload PDF (8527K) -
Noboru NAKASHIMA, Kenzi SEKINE, Noritsune YAMADA, Susumu HAYASHI, Kuni ...1975 Volume 27 Issue 5 Pages 441-448
Published: September 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSThe case was a 53 years old woman with uterine myoma and vaginal cyst, suffering from intermittent complte urinary retention for several years and repeating occasional high fever which had no relation with the urinary retention. As a result of various examinations, inter mittent complete urinary retention was presumably caused by retroflexed uterus of newborn baby's head size, but the source of the high fever remained unknown.
Abdominal hysterectomy carried out on May 2, 1974 revealed that the left ureter was doubled, and one of the mchanged to a solid tube of 1.0-1.5cm in diameter over the whole length.
The upper end of the tube ended with a thumb sized cul-de-sac at the height of the first to second lumber vertebra. On the other hand, the lower end of the tube was narrowed and obstructed just above the urinary bladder.
The tube was filled with pus which certainly was the cause of occasional high fever.View full abstractDownload PDF (12563K)
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