ADVANCES IN OBSTETRICS AND GYNECOLOGY
Online ISSN : 1347-6742
Print ISSN : 0370-8446
ISSN-L : 0370-8446
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Volume 32, Issue 5
Displaying 1-4 of 4 articles from this issue
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  • Studies on Experimental SFD Induced by Actinomycin D
    Katsutada HIRAOKA
    1980 Volume 32 Issue 5 Pages 437-448
    Published: September 01, 1980
    Released on J-STAGE: October 11, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.32.437
    JOURNAL FREE ACCESS
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    It has been well known that maternal environment during pregnancy might affect prenatal growth and neonatal development. Recently SFD became a major problem in obstetrics. Studies have been made of SFD occurring in the third trimester of gestation from viewpoint of uteroplacental bloodflow but the cause of SFD occurring in the second trimester remains unknown. To resolve this problem, in the present work we have investigated experimental SFD in the second trimester.
    SFD was induced by actinomycin D, a nucleic acid synthesis inhibitor, and administered to maternal rats in midpregnancy. Wistar female rats weighing about 200g were used. They were divided into four groups and acute toxicity and teratogenicity tests were performed.
    The results were as follows:
    1. AcD administration after the 10th day of gestation showed low teratogenicity.
    2. SFD occurrence rate was 72% in the AcD group treated at the 11th day of gestation.
    3. Fetal body weight at the 20th day of gestation were 3.50±0.22g (AcD group) and 4.24±0.20g (control .group).
    4. Critical period of placenta was from the 9th day to the 14th day of gestation.
    5. DNA synthesis rate of the fetal liver was most active at the 16th day of gestation.
    6. Glucose transport was lowered by AcD.
    7. Protein synthesis rate in the fetal liver and placenta was inhibited by AcD.
    8. Placental alkaline phosphatase, total ATPase and Na+, K+ ATPase activity were decreased by AcD.
    These results suggest that placental damage in midpregnancy does affect fetal development
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  • [title in Japanese]
    [in Japanese]
    1980 Volume 32 Issue 5 Pages 449-453
    Published: September 01, 1980
    Released on J-STAGE: October 11, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.32.449
    JOURNAL FREE ACCESS
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    [in Japanese]
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  • Two Cases of Delivery of the Pregnant Complicated by ASD and Observed her Cardiovascular Conditions by Plethysmogram
    Ichiro SHINTANI
    1980 Volume 32 Issue 5 Pages 455-464
    Published: September 01, 1980
    Released on J-STAGE: October 11, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.32.455
    JOURNAL FREE ACCESS
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    The pregnancy and delivery of 2 women with ASD are described.
    A 41-year-old multipara was diagnosed as having ASD complicated by mitral requrgitation, chronic endocarditis and toxemia of pregnancy. Cardiac output decreased, heart strength weakened and oedema occurred on the whole body at and after the 34th week of pregnancy. Rapid digitalization was made with lanatoside C and furosemide was given for diuresis. She delivered vaginally a female baby weighing 3, 380 g without developing any complications.
    The other case was a 26-year-old primipara with ASD complicated by mild mitral regurgitation. The caesarean section was performed 3 weeks and 3 days after term because placental dysfunction sndrome appeared. A girl weighing 2, 900g was born, showing no malformation.
    As a useful, conservative method for observing haemodynamics, the electronic plethysmography was applied to these two cases. In both cases, the plethysmograms showrd evident decreases in cardiac output and weakening of contractile force.
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  • A Case of Primary Fallopian Tube Carcinoma Complicated Uterine Body Myoma
    Ichlro SHINTANI, Masamichi SASAKI
    1980 Volume 32 Issue 5 Pages 465-474
    Published: September 01, 1980
    Released on J-STAGE: October 11, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.32.465
    JOURNAL FREE ACCESS
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    A case of the primary carcinoma of the Fallopian tube complicated by myoma uteri corporis was found.
    The patient, a 39-year-old para (II), has been disturbed with slightly bloody genital fluid for the last one year.
    Vaginal smear test before operation showed the (II)nd class of Papanicolaou's staging.
    It seemed from local macroscopic findings that there was hydrosalpinx with uterine body myoma, because the surface of the left Fallopian tube was completely intact except swelling like a sausage.
    So the abdominal total hysterectomy with left adnexectomy was performed.
    Histological examination revealed papillary, partially alveolar-medullary adenocarcinoma of the left tube.
    After surgery she received chemotherapy with furuorouracil, cyclophosphamide, mitomycin C and chromomycin A3 and is living without disease over 9 months.
    Reference is made to 81 cases of the primary Fallopian tube carcinoma reported in Japan
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