All issues
Volume 46 (1994)
- Issue 6 Pages 689-
- Issue 5 Pages 559-
- Issue 4 Pages 379-
- Issue 3 Pages 283-
- Issue 2 Pages 165-
- Issue 1 Pages 1-
Volume 46, Issue 6
Displaying 1-6 of 6 articles from this issue
- |<
- <
- 1
- >
- >|
-
Gestational change of platelet aggregation inhibiting activity of brush border membraneShinobu AKADA1994 Volume 46 Issue 6 Pages 689-697
Published: November 01, 1994
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSTo investigate the platelet aggregation inhibiting mechanism of human placental chorioepith-elium, we compared the platelet aggregation inhibiting activity of human placental chorioepithelial brush border membrane vesicles (BBMV) and basal plasma membrane vesicles (BPMV) in early, mid and late gestation, and obtained the following results.
(1) Strong platelet aggregation inhibiting activity was found in BBMV of every stage of gestation. BBMV inhibited platelet aggregation induced by ADP (adenosine diphosphate) and arachidonic acid. In contrast, BPMV showed no detectable platelet aggregation inhibiting activity.
(2) We found no difference in the BBMV's inhibiting activity against ADP and arachidonic acid induced platelet aggregation in each stage of gestation.
(3) Quite high ADP degrading activity was present in BBMV of every stage of gestation. The platelet aggregation inducing activity of ADP was quickly lost when ADP was preincubated with BBMV. We found no difference in the BBMV's ADP degrading activity of each stage of gestation.
(4) Platelet thromboxane B2 production was inhibited by BBMV of each stage of gestation. We found no difference in the BBMV's inhibiting activity against platelet thromboxane B2 production in each gestational stage.
These results showed that chorioepithelial brush border and basal plasma membrane of the human placenta have markedly different properties with respect to platelet aggregation inhibiting activity. It was indicated that platelet aggregation within the intervillous space of placenta was controlled by the platelet aggregation inhibiting activity of chorioepithelial brush border membrane from early stage of gestation.
[Adv Obstet Gynecol 46 (6) 689-697, 1994 (H6.11)]View full abstractDownload PDF (1246K) -
Takao KAMIYA, Atsushi KAWATA, Shinji URAKAWA, Kaoru OKAMOTO, Ryosuke K ...1994 Volume 46 Issue 6 Pages 698-705
Published: November 01, 1994
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSTo elucidate the direct effects of nicotine on the ovaries, buserelin acetate (LH-RH agonist) was used to suppress the hypophyseal-ovarian function, and the effects of nicotine on the ovarian function and the ovulation were morphologically and endocrinologically studied. Twenty adult female rats were daily given 10μg buserelin. On the tenth day in the studies, all rats were in constant diestrus and divided into 4 groups. Rats of group 1 were daily given 10μg nicotine, group 2, 100, ug, group 3, 1000μg, and group 4 was given physiologic saline solution as control. All rats of 4 groups were given PMSG on the 29th day and hCG on the 31st day, and all rats were laparotomized 12 hours after hCG injection. The serum estradiol (E2) concentrations were 17.6±3.9, 18.5 ±3.6, 16.4±1.1, and 16.3± 1.8 pg/ml for group 1, 2, 3, and 4 respectively, but the numbers of ova recovered from their oviducts were 24.2±6.2, 16.0±4.5, 10.8±3.6, and 33.4±4. 7. There were almost no differences of morphological changes in the ovaries of the 4 groups.
These results suggested that in the rat, nicotine did not act on the steroidgenesis in the ovaries, but inhibited ovulation.
[Adv Obstet Gynecol 46 (6) ; 698-705, 1994 (H6. 11)]View full abstractDownload PDF (6111K) -
A review of 88 casesMinoru AKIYAMA, Kohji WAKUDA, Keiko NAKANISHI, Hiroyuki FURUKAWA, Masa ...1994 Volume 46 Issue 6 Pages 706-714
Published: November 01, 1994
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSThe therapeutic results and outcome were analyzed in 88 patients with carcinoma of the corpus uteri (endometrial carcinoma) who were diagnosed and treated during the 14 years since our hospital was established. The five-year survival rates for each stage of cancer at the time of surgery were 93.4% for stage I, 100.0% for stage II, 34.1% for stage III and 20.0% for stage IV. The five-year survival rate for all 88 patients was 72.3%. Of the 88 patients, 9 had recurrence of tumor, most frequently in the vaginal wall or lungs and within 2 years after surgery. Of the 10 patients who were found before or during surgery to have lymph node metastases, only one survived for 3 more than years. Concerning endometrial carcinoma, it is still controversial which therapy should be selected for each stage of this cancer, although there are widely accepted principles for the treatment of each stage of cervical carcinoma. If the stage and other features of endometrial carcinoma can be assessed preoperatively with greater reliability, it may be possible to select an optimal therapy for individual cases, and the resectability of this type of tumor may be increased. In recent years, anti-cancer drug sensitivity tests have begun to be used clinically. If these tests are utilized to select an optimal combination of drugs to which an individual patient is most responsive and to avoid the use of ineffective drugs, postoperative chemotherapy for endometrial carcinoma will be more effective, leading to better prognosis. [Adv Obstet Gynecol 46 (6) 706-714, 1994 (H6.11)]View full abstractDownload PDF (1465K) -
Naohiko UMESAKI, Hiroaki NAKAMURA, Naoki KAWAMURA, Yasushi KANAOKA, Ic ...1994 Volume 46 Issue 6 Pages 715-721
Published: November 01, 1994
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSThe significance of postoperative radiotherapy to the patients with carcinoma of the cervix, postoperative stage 1B with bulky growth of primary lesion or positive pelvic lymph node metastasis and stage 2 was evaluated.
Four hundred and three patients underwent radical hysterectomy at the Hospital of Osaka City University between January 1971 and December 1992. Of these patients, 111 patients received postoperative radiotherapy. An average of 50 Gy. of whole-pelvis radiotherapy was administered to each subject in the postoperative radiation group. Patients were categorized according to the postoperative clinical stage, pelvic lymph-node metastasis and size of their primary lesion. The utility of postoperative radiation therapy was analyzed according to the recurrence and survival rates.
The postoperative radiotherapy was found to reduce the recurrence rate in group pT2, P4-5 of primary lesion and no pelvic lymph-node metastasis. However, no effect on the survival rate in this group was discerned. No increase in the survival rate was found in any group.
In conclusion, postoperative radiotherapy for patients with cervical cancer was sustained until appearance of recurrence in consideration of side effect. [Adv Obstet Gynecol 46 (6); 715-721, 1994 (H6.11)]View full abstractDownload PDF (1147K) -
Hiroaki SHIBAHARA, Tomohiro SHIOTANI, Akiko HASEGAWA, Yoshikazu IKEDA, ...1994 Volume 46 Issue 6 Pages 722-727
Published: November 01, 1994
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSThere have been several reports of ectopic pregnancies resulting from in vitro fertilization and embryo transfer (IVF-ET). Of 747 transfer cycles between March 1983 and December 1993, nine (12.0 %) of the resulting 75 clinical pregnancies were ectopic. Six ectopic pregnancies were ampullary, two were isthmian and one was ovarian. The rate of ectopic pregnancies in the group of the infertile patients between 35 to 39 years old was higher than those in younger groups, but the difference was not significant. There was a significantly lower incidence of ectopic pregnancies in the infertile women with sperm-immobilizing antibodies (SI-Abs) compared to the control, that was why most of the infertile women with SI-Abs had normal tubal passage. The test results from hysterosalpingography (HSG) or diagnostic laparoscopy revealed that the infertile patients with tubal problems such as perifimbrial adhesion or disturbance of tubal passage had significantly greater incidence of ectopic pregnancies. A patient was treated for ampullary pregnancy by the method of laparoscopy-assisted extra-corporeal salpigectomy, and her postoperative course was unventful.
We conclude that the patients with abnormal tubal passage are at risk of developing ectopic pregnancy in IVF-ET. Prophylactic proximal tubal occlusion should be considered for such women with abnormal tubal passage at the time of diagnostic laparoscopy or therapeutic laparotomy. [Adv Obstet Gynecol 46 (6); 722-727, 1994 (H6.11)]View full abstractDownload PDF (1039K) -
1994 Volume 46 Issue 6 Pages 734-764
Published: November 01, 1994
Released on J-STAGE: July 05, 2011
JOURNAL FREE ACCESSDownload PDF (17756K)
- |<
- <
- 1
- >
- >|