All issues
Volume 49 (1997)
- Issue 6 Pages 623-
- Issue 5 Pages 507-
- Issue 4 Pages 365-
- Issue 3 Pages 171-
- Issue 2 Pages 91-
- Issue 1 Pages 1-
Volume 49, Issue 2
Displaying 1-6 of 6 articles from this issue
- |<
- <
- 1
- >
- >|
-
Tomoyo YASUI1997 Volume 49 Issue 2 Pages 91-98
Published: March 01, 1997
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSThe purpose of this study was to gather data from experimental animals as a basis for future clinicaI applications of plasmapheresis to remove an anemia-inducing substance (AIS) from weight losing patients with tumors. A fraction containing AIS was obtained by chromatography on a phenyl-Sepharose column of plasma from blood sampled from two groups of rabbits with cachexia 55 days after inoculation with VX2 carcinoma cells. One group was untreated and the other underwent plasmapheresis twice a week for 4 weeks to remove AIS. A portion of a fraction was added to the culture medium of murine 3T3-L1adipocytes, and the amount of glycerol released into the medium was measured as an index of lipolysis. To other cultures, a plasma fraction obtained in the same way from rabbits without tumors and fed as usual (controls), or from such rabbits with feed withheld, was added. Adipose tissue was obtained from three of these groups of rabbits (with cachexia, starved, or fed as usual) and the incorporation of radiolabelled glucose into glycerides by the tissue was measured. Glycerol release into medium from 3T3-Llcells treated with the fraction containing AIS from plasma of cachexia before and after plasmapheresis or with the same fraction from starved and healty control rabbits were 0.370, 0.313, 0.265 and 0.288 1cmol/105 cells in 8 hr, respectively. Intracellular levels of triglycerides for each group was 0.294, 0.327, 0.316 and 0.340 pmol/105cells, respectively. Incorporation of radiolabelled glucose into adipose tissue from cachectic, starved, and control rabbits were 15.9, 46.8 and 18.0 x 105 cpm/g per hour, respectively. Glycerol release from the materials were 511, 365 and 201 nmol/g per hour. These data suggests that pathophysiology characterized to lipid metabolism in cachexia includes accelerated lipolysis and reduced lipogenesis and that the pathological changes may be improved by plasmapheresis. [Adv Obstet Gynecol 49 (2); 91-98, 1997 (H9.3)]View full abstractDownload PDF (4196K) -
Yoshiaki YAMAMOTO, Minoru AKIYAMA, Nobuyuki KITA, Ichirou YAMADE, Tosh ...1997 Volume 49 Issue 2 Pages 99-105
Published: March 01, 1997
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSThis study was conducted to assess the usefulness and limitations of conventional methods for treating patients with infertility, so as to determine the most appropriate time for assisted reproductive technology (ART). Six hundred and eighty two couples with infertility treated in Shiga university hospital for ten years since 1984 were studied. In all case, age exceeded 29 years old and those with infertility for more than four years showed fewer pregnancies. Conception for each infertility factor was 59.9% in patients with ovulatory disorder, 46.6% with luteal phase defect, 31.0% in endometriosis, 20.6% for the tubal factor, 21.9% for the male factor and 15.3% for others. In the first 30 months after the start of treatment 89.1% of the women were pregnant and only 10.9%were pregnant during the following 36 months. It is evident from the present study that, for patients after 30 months treatment by conventional methods, more than 29 years of age, more than four years infertility or tubal, male, uterine factor or unknown factors, the pregnancy rate is low and they ART should be recommended. [Adv Obstet Gynecol 49 (2); 99-105, 1997 (H9.3)]View full abstractDownload PDF (2885K) -
Emiko ABE, Hiroshi OZASA, Shigeo YURA, Takashi NONOGAKI, Kenji IDA, To ...1997 Volume 49 Issue 2 Pages 106-109
Published: March 01, 1997
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSWith recent advances in the technique of hemodialysis, patients on hemodialysis live longer and the probability of encountering such patients with malignant disease has increased. Surgery has previously been considered relatively contraindicated for patients on hemodialysis who harbored malignant disease. We report here a case of surgically-treated endometrial carcinoma in a patient on long-term hemodialysis. [Adv Obstet Gynecol 49(2); 106--109, 1997(H9.3)]View full abstractDownload PDF (1688K) -
Mitsunaga KONISHI, Masafumi KOSHIYAMA, Masumi YOSHIDA, Maki TAKEMURA, ...1997 Volume 49 Issue 2 Pages 110-115
Published: March 01, 1997
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSCPT-11 was given to 14 patients with CDDP-resistant recurrent ovarian carcinoma and 6patients with radiotherapy-resistant uterine cervical carcinoma between August 1994 and April 1996. At first, CPT-11 was given to 4 ovarian carcinomas in the defined method A of 100 mg/m2/ week. However, the side effects of diarrhea and leukocytopenia were too severe to maintain the therapy. In an effort to reduce these side effects, a new administration method was devised: an initial dose of 70mg/m2 followed by increasing the dose to 100 mg/m2 every 10 days. Administrating the medication nine times in this method was defined as one course of therapy. This new method of administrating CPT-11 was practiced in the following 16 cases. It proved to be apparently helpful in reducing the previous side effects of diarrhea and leukocytopenia. Since both grade3 diarrhea and grade3 leukocytopenia were particularly reduced, we could smoothly treat every patient according to our schedule. In view of the anti-cancer effect, response was observed in 2 of 10 ovarian carcinomas, and 3 of 6 uterine cervical carcinomas inculuding 1adenocarcinoma. We could suggest that our new method of CPT-11 administration is clinically useful. [Adv Obstet Gynecol 49 (2); 110 115, 1997 (H9.3)]View full abstractDownload PDF (3296K) -
Shinji TOYODA, Yoshinari HIRANO, Takuo TANIGAWA, Hiroyasu HISANAGA, Ke ...1997 Volume 49 Issue 2 Pages 116-119
Published: March 01, 1997
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSThe patient was 53-year-old woman who had undergone four pregnancies and had one child. She had been hypertensive for one year. The chief complaint was abdominal distention, and ascites with positive cytology was noted. There was no remarkable primary lesion on ultrasonography or MR imaging. We suspected ovarian cancer or SSPC, and she was given neo-adjuvant CAP chemotherapy, CDDP(80mg/body) by intraperitoneal injection, ADM(50mg/body) and CPM(400mg/body) by intravenous injection. Soon after she completing one course chemotherapy, ascites was significantly reduced, and laboratory data showed that serum CAl25 had decreased from 1600 to 180 U/ml and that serum TPA was reduced from 390to 110 U/1. After completing three courses of chemotherapy, the patient underwent surgery. Simple total hysterectomy with bilateral salpingo-oophorectomy, omentectomy and pelvic and paraaortic lymph node resection were performed. At surgery, both ovaries were normal in size and shape. Ascites was slight, but there were many small papillous tumors about the size of a red bean in the omentum, right mesosalpinx, vesicouterine peritoneum, cul-de-sac, and caecum. Histological diagnosis was surface serous peritoneal adenocarcinoma. Clinical stage was III c (FIGO). After surgery, she was given 6 more courses of the same chemotherapy. The patient has survived without evidence of disease for 38 months to date. [Adv Obstet Gynecol 49 (2); 116.119, 1997 (H9.3)]View full abstractDownload PDF (4618K) -
1997 Volume 49 Issue 2 Pages 120-124
Published: March 01, 1997
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSDownload PDF (518K)
- |<
- <
- 1
- >
- >|