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Volume 51 (1999)
- Issue 6 Pages 551-
- Issue 5 Pages 489-
- Issue 4 Pages 325-
- Issue 3 Pages 179-
- Issue 2 Pages 135-
- Issue 1 Pages 1-
Volume 51, Issue 2
Displaying 1-5 of 5 articles from this issue
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Naoya HARADA, Hajime MORIKAWA, Shigeru SAITO1999 Volume 51 Issue 2 Pages 135-144
Published: 1999
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSWe investigated physiological effects of IL-4 and IL-7 on trophoblasts, focusing mainly on the mechanism of hCG release. Trophoblasts were isolated from placental villus at gestational ages between 6 weeks and 11 weeks, and cultured. At culture medium exchange 48 hours after initiation of culture, IL-4, IL-7, IL-6 or GnRHa was added, and hCG concentration in the culture supernatant was determined by EIA. In addition, anti -IL-6R antibody, anti-IL-2RYantibody, PKC inhibitor (H7), PKA inhibitor (H8), calmodulin inhibitor (W7)or tyrosin kinase inhibitor (Herbimycin A) was simultaneously added with the above cytokines in another set of cell culture to investigate the effects of these subjects. As a result, IL-4 and IL-7 promoted hCG release from chorionic cells similarly to IL-6 and GnRHa. This effect was dependent on the time and concentration, and additive effects were also observed. The effect was not inhibited by anti-IL-6R antibody but was inhibited by addition of anti-IL-2RYantibody. H7, H8 and W7 did not inhibit IL-4 or IL-7-induced hCG release response, but the release effect of IL-4 and IL-7 was inhibited by Herbimycin A. Furthermore, high expression of tyrosin kinase. JAKI and JAK3 on the trophoblasts was detected by immunohistological examination. These results suggested that IL-2RY is essential for hCG release from chorionic cells and this response is mediated by tyrosin kinase. [Adv Obstet Gynecol 51(2); 135-144, 1999(H11.3)]View full abstractDownload PDF (8394K) -
Yoshiro HANADA, Kazuko MITO, Hiroyuki YAMAMOTO, Ryoji KUSHIMA, Tadao K ...1999 Volume 51 Issue 2 Pages 145-150
Published: 1999
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSThe synchronous occurrence of carcinoma in the ovary and the endometrium is an uncommon but well recognized event. The simultaneous presence of multiple tumors may indicate either metastatic disease or independently developing neoplasms. The distinction between the two can be difficult but is important to determine the aggressiveness of such lesions which consequently influences the prognostic judgement and therapeutic approach to be taken. In particular, if these lesions are separate, limited primary neoplasms of the ovary and endometrium, they can be treated successfully by surgery alone, but if they are metastatic, extensive chemotherapy may be required. In this report, we reviewed a case we experienced with synchronous dual primary carcinomas of the ovary and endometrium. [Adv Obstet Gynecol 51 (2); 145 150, 1999 (HI 1.3) ]View full abstractDownload PDF (6552K) -
Shinji TOYODA, Nobuo KURAI, Yoshio ITANI, Keizo YAMAGAMI, Katsutada HI ...1999 Volume 51 Issue 2 Pages 151-154
Published: 1999
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESShe patient was a 26-year-old woman who had no history of pregnancy orillness. The chief complaints were genital bleeding and lower abdominal pain. Extra-uterine adenocarcinoma with positive uterine cervical cytology was suspected at first examination. However, endometrioid adenocarcinoma with positive uterine corpus cytology and endometrial biopsy was noted. The patient underwent surgery on July 24th, 1997. Simple total hysterectomy with bilateral salpingo-oophorectomy was performed. Histological diagnosis was moderate differentiated endometrioid adenocarcinoma. Myometrial invasion was below 1 / 3, and positive vessel permeation was found. Ascites with positive cytology identified this case as stage ilia. After surgery the patient was given 3 courses of adjuvant CAP chemotherapy, ADM (50mg / body), CPM (500mg / body) and CDDP (100mg /body) by intravenous injection. The patient has survived without evidence of a recurrence for 12 months. [Adv Obstet Gynecol 51 (2); 151 154, 1999 (H11.3) ]View full abstractDownload PDF (4264K) -
Takanobu KANAMORI, Masafumi NONOGAKI, Toshiyuki TACHIBANA, Ikuo KONISH ...1999 Volume 51 Issue 2 Pages 155-159
Published: 1999
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSUterine lipoleiomyoma is a rare variant of leiomyoma that microscopically contains large amount of fat cells, and only 20 cases have been described in Japan. Most of cases were diagnosed incidentally at the postoperative histopathological examination. Here we report a case of a uterine lipoleiomyoma, which was preoperatively diagnosed by MRI findings. T1 weighted MR images showed a well-demarcated mass with high intensity in the uterine body. Fat content with in the tumor was confirmed by a T2 fat suppression image. Microscopically, the tumor was confirmed to be lipoleiomyoma that consisited of numerous matured fat cell which were intermingled with smooth muscle cells. Differential diagnosis among uterine smooth muscle tumors by MRI is discussed. [Adv Obstet Gynecol 51 (2); 155 159, 1999 (H11.3) ]View full abstractDownload PDF (6539K) -
Tatsuya NAKAJIMA, Hirokazu YORIOKA, Takashi OSAKI, Ryosuke KONDO, Taka ...1999 Volume 51 Issue 2 Pages 160-164
Published: 1999
Released on J-STAGE: September 27, 2010
JOURNAL FREE ACCESSPolymyositis (PM) is collagen disease that affects striated muscle. We present a case of polymyositis occurring during pregnancy. The patient was a 27-year-old pregnant woman (gravida 1, para 1). She had neither a past nor a family history of collagen disease. At 14 weeks of gestation, she complained of myalgia, muscle weakness in all extremities, and gross hematuria, and was admitted to our hospital. The laboratory data revealed extreme elevation of creatinine kinase (CK) in serum (43, 560IU / 1). The findings of an electromyogram showed a myogenic pattern. The diagnosis of polymyositis was made from these findings and 60mg / day of prednisolone was started. The laboratory findings and clinical symptoms improved dramatically and the disease was inactive during the rest of the pregnancy by prednisolone treatment. A healthy male infant weighing 2880g was born at 37 weeks of gestation without prolonged labor, and the clinical course after delivery was unremarkable. In the literature, it is reported that the risk of intrauterine growth retardation, intrauterine fetal death or neonatal death in pregnancies complicated with PM is higher than that in normal pregnancies. Additionally, some cases are active or exacerbated during pregnancy even though corticosteroid therapy is administered. Therefore, pregnancies associated with PM should be managed carefully. In this case, maternal and fetal outcomes were successful because of a good response to corticosteroids. The successful management of polymyositis occurring during pregnancy could be dependent on the response to corticosteroid therapy. [Adv Obstet Gynecol 51 (2); 160 164, 1999 (H11.3)]View full abstractDownload PDF (2002K)
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