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Volume 41, Issue 7
Displaying 1-9 of 9 articles from this issue
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Sang-Gwon Lee, Manabu Nashimoto, Yoshio Otani, Kazunori Ishizeki, Hisa ...2004 Volume 41 Issue 7 Pages 500-507
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDispersion performance of Dry Powder Inhaler (DPI) depends largely upon the inhalation patterns of patients. In the present work, the inhalation patterns of healthy and COPD subjects with DPI were measured and a breathing simulator was constructed. Then, a measurement method with a gravitational settling chamber that allowed the particle size measurement without the dispersion during the measurement was proposed for the measurement of DPI dispersion performance under the simulated inhalation conditions. As a result, it was found that an increase in pressure drop of DPI markedly reduces the peak flow rate and that the dispersion performance of DPI is greatly affected by the inspiration patterns. The experimental data also suggested that Andersen impactor which is commonly used for the evaluation of dispersion performance of DPI is not suitable for this purpose because the dispersion of drug particles in the impactor is inevitable.View full abstractDownload PDF (4517K) -
Kouichi Higashiyama, Hideki Kanda, Hiromi Shirai, Hisao Makino, Ryoich ...2004 Volume 41 Issue 7 Pages 508-513
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSIn this study, we examined influences of temperature, humidity and coal ash characteristics on hardening phenomena of coal ash beds. Coal ash beds were moistened and hardened at a high relative humidity and we found that hardening is prevented by removing sulfur trioxide on the surface of coal ash, e. g., by washing it in water or by contacting it with ammonia gas. Therefore, sulfur trioxide on the surface of coal ash plays an important role on the hardening of coal ash bed. In addition, moistened coal ash bed was hardened more by drying. The mechanism of hardening is such that alkaline materials in coal ash react with sulfuric acid formed by the adsorbed moisture and sulfur trioxide to produce sulfates by the neutralization reaction. Crystalline of sulfate, which is formed by drying, interconnects coal ash particles.View full abstractDownload PDF (741K) -
Hiromitsu Yamamoto, Wataru Hoshina, Homare Kurashima, Hirofumi Takeuch ...2004 Volume 41 Issue 7 Pages 514-521
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe objective of the present research is to develop a new particulate preparation process for dry powder inhalation by which peptide-loaded PLGA nanospheres are granulated with sugar alcohol (mannitol, c. a. 4μm in diameter). A spray drying fluidized bed granulator was used to form soft matrix composite granules. Nanosphere suspension can be readily obtained by dispersing the composite granules in distilled water. The composite granules showed inhalation performance superior to that of freeze-dried nanosphere powder. More than 50% of composite granules were delivered to the bronchioles and alveoli of a rat. The composite granules of insulin-loaded nanosphere have strong and prolonged pharmacological effect compared to the inhalation of insulin solution.View full abstractDownload PDF (4198K) -
Effect of Initial Height on Sedimentation BehaviorTakamasa Mori, Makoto Ito, Tadamitsu Sugimoto, Hidetoshi Mori, JunIchi ...2004 Volume 41 Issue 7 Pages 522-528
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSSlurry compressibility was evaluated by using hydrostatic pressure measurement. The dependency of sedimentation behavior and final packing fraction of sediment on the initial slurry height was studied. The final packing fraction of sediment decreased with the initial slurry height for slurries with pH5.5. It was also found that the hydrostatic pressure at the vessel bottom decreased gradually in the initial stage of sedimentation but dropped abruptly after 20h. These results suggested that the particles were well dispersed in the initial stage of sedimentation, however the flocculation of particles proceeded during the sedimentation. The local packing fraction of final sediment layer was measured from the intensity of gamma ray penetration through the sediment layer. We found that the sediment layer formed from the slurry with pH5.5 consisted of two layers, i. e., dense and loose zones, and that the loose zone increased with the initial height, which led to a smaller final packing fraction of sediment layer.View full abstractDownload PDF (789K) -
Yasuyuki Miyano, Yasushi Kikuchi2004 Volume 41 Issue 7 Pages 529-534
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (3638K) -
Takayuki Hirai2004 Volume 41 Issue 7 Pages 535-540
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (11275K) -
Katsunori Ishito2004 Volume 41 Issue 7 Pages 541-542
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (1777K) -
Yoshikazu Kuga2004 Volume 41 Issue 7 Pages 543-545
Published: July 10, 2004
Released on J-STAGE: January 24, 2011
JOURNAL FREE ACCESSDownload PDF (3931K) -
[in Japanese]2004 Volume 41 Issue 7 Pages 547
Published: July 10, 2004
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (116K)
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