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Volume 25, Issue 6
Displaying 1-13 of 13 articles from this issue
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Yoshiaki KAWASHIMA1988 Volume 25 Issue 6 Pages 337
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
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Tooru MAKI, Nobuo UMEKI, Yasuo OZAWA1988 Volume 25 Issue 6 Pages 338-343
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSIn order to control the release rate of the drug from the pharmaceutical dosage form, a useful method for coating the fine wax powder to the surface of the drug-containing granules with the binder solution is by using the tumbling agglomeration apparatus that was developed here. We used hydrogenated castor oil, stearic acid and carnauba wax as coating materials and investigated the effects of wax species, particle size, coating amount and heat treatment on the drug release.
The release rate of the drug from the wax-coated granules could be extensively controlled by varying these conditions. Heat treatment was easy and useful to control the drug release. This method is applicable to the preparation of the controlled-release dosage.View full abstractDownload PDF (4306K) -
Keijiro TERASHITA, Munehiro MITSUI, Kei MIYANAMI, Kazunori SAKAMOTO, T ...1988 Volume 25 Issue 6 Pages 344-349
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSMixtures of magnetic powder materials, having different flowabilities, were continuously kneaded. The materials obtained from the kneading were used to make videotapes by diluting and dispersing them, and their kneading and dispersion states were evaluated, respectively.
The kneading state could be estimated from the microscopic observation of binder coated on magnetic powder and measurement of the mixing torque required in kneading. The dispersion state could be evaluated from gloss, X-ray microanalysis and magnetic hysteresis curve.
From the results, it was clarified that the low cohesiveness and high flowability of the mixture contribute to good dispersion of magnetic powder materials. They also contribute to a satisfactory kneading state which ensures high-grade videotape results from a well-dispersed state of materials.
In conclusion, it can be said that a performance of videotape is dependent on its kneading state.View full abstractDownload PDF (4105K) -
Masazumi IHZUKA, Takayoshi KIMURA, Jiro KOGA, Isao ENDO1988 Volume 25 Issue 6 Pages 350-353
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe liposomes encapsulating a Adenosine-3′, 5′-cyclic Monophosphate (c-AMP) sodium salt solution were prepared by the reverse-phase evaporation method. The liposomes were made from the mixture of dipalmitoyl lecithin, dicetyl phosphate and cholesterol. The encapsulation of c-AMP sodium salt in liposomes was determined by the measurement of the optical density at 259nm. The size of liposomes was determined by the photon-correlation method.
The experimental results show that these liposomes were reduced in size up to 0.4-0.5μm by the addition of dicetyl phosphate. The encapsulation ratio of the c-AMP salt solution increased up to about 55% by the addition of cholesterol.View full abstractDownload PDF (423K) -
Keijiro TERASHITA, Naruo YABE, Kiichi IZUMIDA, Kei MIYANAMI1988 Volume 25 Issue 6 Pages 354-358
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSA keading experiment was carried out on thermoplastic resin and carbon black (materials for toner) with a continuous kneader using the kneading temperature as a variabe. In addition to measuring the mixing torque in kneading and the residence time of the material, evaluation of the condtion of dispersion was attempted by means of image analysis.
The results showed that image analysis enables the assessment of the condition of carbon black dispersion in the kneaded material. It also shows, that the degree of dispersion in the kneaded material both radially and axially increases depending on the material in which the mixing action works as well as with increases in the kneading energy.View full abstractDownload PDF (1886K) -
Kanji MATSUMOTO, Hideaki AKUTSU, Akihiko YOSHIMIDZU, Gonghong HONG, Ki ...1988 Volume 25 Issue 6 Pages 359-364
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSEquipment for measuring the wettability (i. e. the contact angle) of hydrophobic powder was newly developed, based upon the so-called constant flow method. This equipment has a feature in which the specific surface area of the powder, the threshold pressure at which a liquid begins to penetrate the powder bed and its contact angle are calculated and printed out. This happens when the values related to the operational conditions and the physical properties of air, liquid and powder used in the measurement are put in advance into the computer installed in this equipment.
The availability of this equipment was confirmed by investigating the effect of operational factors such as the feed rate of pure water, the porosity of the powder bed and its height on the contact angle of aluminum hydroxide powder treated with stearic acid. The relationship between the contact angle of the sample powder and the concentration of stearic acid, the mixing time, the dispersion state in pure water or the amount of DOP (dioctyl phthalate) absorbed was also obtained.View full abstractDownload PDF (2054K) -
Kanji MATSUMOTO, Yuji TABATA, Gonghong HONG, Kinnosuke WATANABE1988 Volume 25 Issue 6 Pages 365-370
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe equipment for measuring the wettability (i. e. the contact angle) of hydrophilic powder was newly developed, based on the so-called CST(Capillary Suction Time) method. This equipment has a feature in which the wetting liquid spreads horizontally and radially into the powder bed having a disk shape 2mm thick. The contact angle is calculated from the time (CST) which it takes for the wetting liquid to move from the 1st sensor to the 2nd one. The wetting front was detected by either an electrical conductance method or a reflecting light method.
The availability of this equipment was confirmed by investigating the effect of the type of sensor, the distance between the two sensors, the porosity of the powder bed, and the temperature, etc. on the contact angle of untreated aluminum hydroxide powder or that treated with stearic acid.View full abstractDownload PDF (2298K) -
Kenichi SUGIMORI, Shoichi MORI, Yoshiaki KAWASHIMA1988 Volume 25 Issue 6 Pages 371-374
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe compressibility of powders was evaluated by using residual die wall pressure and measuring the binding strength of the compacted powders.
The binding strength was reflected in a saturated curve as the compaction pressure increased. However, the residual die wall pressure increased in proportion to the compaction pressure. These phenomena explained the capping behaviors during tableting.
In the binary mixed powders, the binding strength changed in a complicated way, but the residual die wall pressure changed simply with the composition of the mixture. The ratio of these two values was defined as the capping index, and the actual capping tendency was defined as the capping ratio. Good correlation was observed between this index and ratio.View full abstractDownload PDF (419K) -
Sachio MATSUMOTO1988 Volume 25 Issue 6 Pages 375-380
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
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Nobuyoshi KANENIWA, Kanji IMAGAWA, Jun-ichi ICHIKAWA1988 Volume 25 Issue 6 Pages 381-387
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
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Yoshinobu NAKAI1988 Volume 25 Issue 6 Pages 388-394
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
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Wetting and DispersionMasumi KOISHI1988 Volume 25 Issue 6 Pages 395-401
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
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Hideharu HIROSUE, Noriyuki YAMADA, Eiichi ABE1988 Volume 25 Issue 6 Pages 402-406
Published: June 10, 1988
Released on J-STAGE: April 30, 2010
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