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Volume 42, Issue 9
Displaying 1-10 of 10 articles from this issue
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Yoshiaki Kawashima2005 Volume 42 Issue 9 Pages 607
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (2560K) -
Mitsumasa Kimata, Kenji Miyawaki, Masahiro Hasegawa2005 Volume 42 Issue 9 Pages 608-612
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe effect of washing silica sand on the adsorption property was studied using a vessel-type stirred washer. The sand sample was washed with water containing no cleaning agents. The adsorption capacity of silica sand was enhanced when it was washed at a stirring rate of more than 300rpm for 24h. The characteristics of ferrous ion adsorption to the cleaned silica sand surface were also investigated. The desorption experiments carried out with deionized water and a hydrochloric acid showed that the ferrous ions are adsorbed on the cleaned silica sand. The adsorption isotherm is a Langmuir type and the desorption of ferrous ions from the clean silica sand by washing is relatively easy because they are weakly adsorbed on the silica sand (90% of adsorbed ferrous ions are recovered by the washing).View full abstractDownload PDF (614K) -
Kuniaki Gotoh, Tatsuo Daikoku, Tatsuo Nishimura2005 Volume 42 Issue 9 Pages 613-618
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSFluid penetration method is applied in order to evaluate the non-uniformity of a particle bed structure. The apparatus developed consists of a cubic sample box which can be set on either surface. The pressure drops across the packed bed in the packing direction and its perpendicular direction were measured. The fluid penetration resistance in gravitational direction (=packing direction) was higher than that in the perpendicular direction, and the difference depended on the particle size and shape.
In order to find the relationship between the differences and the orientation of particles to the packing direction in a packed bed, experiments were conducted using a model packed bed consisting of uniform cylinders with a diameter of 4mm and a length of 100mm. A correlation was obtained between the orientation angle of cylinder axis to the packing direction and the ratio of specific surface area in perpendicular direction to that in the gravitational direction which were determined by the pressure drop measurements. Non-uniformity of a packed bed structure can be evaluated with the orientation angle to the packing direction using the obtained correlation.View full abstractDownload PDF (2654K) -
Masashi Wada, Mitsuhiko Hata, Masami Furuuchi, Chikao Kanaoka2005 Volume 42 Issue 9 Pages 619-624
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSIt is very important to clarify the mechanism of hardening of a powder layer under humid conditions in order to avoid the potential trouble caused by the layer hardening. This phenomenon is believed to be closely related to the formation of liquid bridge at the contact point of two particles which leads to an increase in adhesion force.
In this paper, the applicability of impedance of an electrical equivalent circuit for a particle-contact point system has been examined for the evaluation of adhesion force at different humidity. An electrical equivalent circuit was designed to express the condition of contacting particles in powder layer and the impedance of conductive and non-conductive particles was calculated at different humidity.
Adhesion force and impedance of a single contact point of particle with liquid bridge has been measured directly by a modified AFM. Based on the measurements, the applicability of impedance for the investigation of the change in adhesion force acting between contacting particles with liquid bridge was discussed.View full abstractDownload PDF (693K) -
Makio Naito, Hiroya Abe, Kazuyoshi Sato2005 Volume 42 Issue 9 Pages 625-631
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSNanoparticle bonding technology is a promising approach to present designs of particles as well as nano/micro structural control of materials. By making use of the unique properties of nanoparticle surface, the bonding can be well conducted at lower temperature without any binders. In this paper, the concept of nanoparticle bonding process is introduced. Examples of particle designs including composite particles are explained. Nano/micro structures of materials fabricated by the process and their applications are also introduced.View full abstractDownload PDF (9897K) -
Katsuhide Terada, Yoko Takada, Yasuo Yoshihashi, Etsuo Yonemochi2005 Volume 42 Issue 9 Pages 632-637
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe crystalline state of drug substance, such as polymorphic forms and crystallinity, in the manufacturing process was analyzed by the Near Infrared Spectroscopy (NIR) calibrated with a set of blend mixture of polymorphs and amorphous samples. The crystalline state of drug substance in the mixture and the tablet was well analyzed by the NIR spectroscopy. However, the crystalline state of drug substance in the granule was determined only when there were no molecular interactions between the drug substance and the excipient since molecular interaction inhibited the accurate evaluation of crystalline state. Chemometrics and spectroscopic measurements will be a useful tool for the evaluation of crystalline state in dosage form when no molecular interaction occurs in the manufacturing process.View full abstractDownload PDF (699K) -
Tadatsugu Tanino2005 Volume 42 Issue 9 Pages 638-647
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSAccording to FDA guidance, PAT (Process Analytical Technology) is a system for designing, analyzing, and controlling manufacturing through timely measurements (i. e., during processing) of critical quality and preformance attributes of raw and in-process materials and processes. A desired goal of the PAT framework is to design and develop well understood processes that will consistently ensure a predefined quality at the end of the manufacturing process. PAT tools can be categorized according to the following: 1) Multivariate tools for design, data acquisition and analysis, 2) Process analyzers, 3) Process control tools, 4) Continuous improvement and knowledge management tools.
In this article, process analyzers are introduced and discussed with their actual application under the recognition of PAT as a system.View full abstractDownload PDF (8158K) -
Yoshihide Mawatari2005 Volume 42 Issue 9 Pages 648-651
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe present study was performed to clarify the operational range for vibro-fluidization of fine cohesive particles (glass beads, dp=6μm). The lower and upper limits of gas velocities for intermittent channel breakage by vibration were obtained experimentally. The lower limit of such gas velocity decreased as the vibration strength increased, while the upper limit had a maximum with a certain vibration strength. This indicates that there is a suitable combination of gas flow and vibration strength to achieve favorable vibro-fluidization.View full abstractDownload PDF (1967K) -
2005 Volume 42 Issue 9 Pages 652-653
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (4025K) -
2005 Volume 42 Issue 9 Pages 655-656
Published: September 10, 2005
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSDownload PDF (236K)
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