Solubilities and initial dissolution rates of indomethacin polymorphs, pure α and γ forms, in water at various temperatures were determined, and from these parameters and temperatures, the heats of solution, ΔH
2(soln), and heats of dissolution, ΔH
2(diss), of these polymorphs were obtained. The activities of these polymorphs in water were calculated using the ideal solubility equation, and the activity coefficients were also calculated from these activities and mole fraction solubilities. The heats of solution, ΔH
2(soln), of these polymorphs were evaluated using melting points, heats of fusion at the melting points, mole fraction solubilities and activation coefficients. Comparing ΔH
2(soln) with ΔH*
2(soln) or ΔH
2(diss), it was suggested that ΔH
2(soln) corresponded to ΔH
2(diss) rather than to ΔH
2(soln).
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