巻号一覧
21 巻, 5 号
選択された号の論文の43件中1～43を表示しています
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小林 五郎, 松田 芳郎, 夏木 令子1973 年 21 巻 5 号 p. 921-925
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーReaction of α, α'-dimethylthiomethylene-2-pyridylacetonitrile (I) and active methylene compounds in dimethyl sulfoxide, in the presence of potassium carbonate, afforded 1-cyano-2-methylthio-4H-quinolizin-4-ones with the corresponding substituent in 3-position. Reaction of some of these 3-substituted compounds with benzylamine produced 2-benzylamino-1-cyano-4H-quinolizin-4-ones. Reduction of one of the 3-substituted compound over Raney nickel catalyst gave 1-cyano-3β-pyridyl-4H-quinolizin-4-one.抄録全体を表示PDF形式でダウンロード (550K) -
米田 文郎, 佐久間 義治, 上野 猷子, 西垣 貞男1973 年 21 巻 5 号 p. 926-930
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリー1, 3-Dimethyl-4-thio-7-azalumazine derivatives (5-thiofervenulins) and 1, 3-dimethyl-4-thio-6-azalumazine derivatives (5-thioisofervenulins) were synthesized by the thiation of 1, 3-dimethyl-7-azalumazine derivatives (fervenulins) and 1, 3-dimethyl-6-azalumazine derivatives (isofervenulins). The 1, 3-dimethyl-4-thio-6-azalumazines were converted into theophyllines by treatment with sodium dithionite in formic acid. These thio-azalumazines displayed low antibacterial activities in vitro.抄録全体を表示PDF形式でダウンロード (595K) -
大村 智, 中川 彰, 山田 陽城, 秦 藤樹, 古崎 昭雄, 渡辺 得之助1973 年 21 巻 5 号 p. 931-940
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーA series of new antibiotics, Kinamycin A, B, C, and D which are mainly effective against gram-positive bacteria, were extracted with chloroform from the broth filtrate of Streptomyces murayamaensis sp. nov. HATA et OHTANI. Kinamycin C (I), C24H20O10N2, m/e 496 (M+), was determined to have an 8-hydroxynaphthoquinone skeleton, nitrile, acetoxyl, and tertiary methyl groups from its ultraviolet (UV), infrared (IR), and nuclear magnetic resonance (NMR) spectra, and was further found to have a unique structure of N-C-N from some chemical reactions and X-ray diffraction. Structure relationship among I and other components A, B, and D was assumed to be due to the difference in the number and position of the acetoxyl group from analyses of IR, NMR, and mass spectra of their acetylated compounds. The antimicrobial activity of the four kinamycins increases with the decreasing number of acetoxy group, in the order of kinamycin C, A, D, and B. In addition, some derivatives obtained during structural studies on I were found to have nearly equal or increased antimicrobia1 activity compared with I and kinamycin D (XI).抄録全体を表示PDF形式でダウンロード (1108K) -
小林 栄1973 年 21 巻 5 号 p. 941-951
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーA series of compounds possessing the pyrazolo[3, 4-d]pyrimidine nucleus were synthesized, characterized and screened for the ability to inhibit xanthine oxidase activity. The compounds were compared with 4-hydroxypyrazolo[3, 4-d]pyrimidine (4), which showed 100% inhibition at a 33 μmole concentration. The structure-activity relationships of the synthesized compounds were discussed. 4-Amino-6-hydroxy-3-phenyl-pyrazolo[3, 4-d]pyrimidine (30b) and 4-amino-3-(p-chlorophenyl)-6-hydroxypyrazolo[3, 4-d]pyrimidine (30c) were found to be as potent inhibitors as allopurinol.抄録全体を表示PDF形式でダウンロード (1161K) -
倉本 戴寿, 菊地 博達, 実森 宏, 穂下 剛彦1973 年 21 巻 5 号 p. 952-959
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーBile salts of six different species of the Anura were investigated by means of thin-layer chromatography, gas-liquid chromatography, and mass spectrometry. Bile of Xenopus laevis contained taurine-conjugated and free forms of 3α, 7α, 12α-trihydroxy-5β-cholestanoic acid and 5β-cyprinol sulfate2) as its chief constituents. Smaller amounts of cholic acid and chenodeoxycholic acid were also detected in the hydrolyzed bile. Neither conjugated bile acids nor bile alcohol sulfates were found in the bile of Bombina orientalis, the chief constituents of which were free 3α, 7α, 12α-trihyboxy- and 3α, 7α, 12α, 24-tetrahydroxy-5β-cholestanoic acids. Hyla arborea japonica contained 5β-ranol sulfate as almost the only bile salt. Rana brevipoda contained taurine-conjugated and free forms of cholic acid and 3α, 7α, 12α-trihydroxy-5β-cholestanoic acid, and 5β-cyprinol sulfate. Rana rugosa had mainly 5α-cyprinol sulfate in its bile. There was also a minor amount of tauro-3α, 7α, 12α-trihydroxy-5α-cholestanoate. Rana limnocharis limnocharis contained taurine-conjugated and free forms of cholic acid and 3α, 7α, 12α-trihydroxy-5β-cholestanoic acid, and 5β-bufol sulfate.抄録全体を表示PDF形式でダウンロード (998K) -
広瀬 徳康, 左右 田茂, 栗山 鎮雄, 豊島 昭二1973 年 21 巻 5 号 p. 960-971
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーThirty one derivatives of 3-alkoxy-1[ω-(N-substituted amino)-3-phenylindolin-2-one and related compounds were synthesized for pharmacological testing. As a preliminary screening test compounds were tested for analgetic-antiphlogistic activity by anti-writhing test in mice. Acute toxicity and gross behavioral changes in mice were also determined. The majority of the compounds produced anti-writhing activity.抄録全体を表示PDF形式でダウンロード (1267K) -
重実 桂助, 溝口 富茂1973 年 21 巻 5 号 p. 972-980
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーModifications were attempted on the renin inhibitors, leucylleucylvalyltyrosine ethyl ester or leucylleucylvalylphenylalanine ethyl ester which were reported in the preceding paper. Borohydride reduction of the above peptide esters, prepared by the solid phase method using bromoacetyl polystyrene, afforded the respective C-terminal carbinol derivatives, which were moderately soluble in water and the renin inhibitory activity was found to be retained. Elongation of the aforementioned tetrapeptide esters or carbinols by a hydrophilic amino acid residue or introduction of the sodiumsulfomethyl group was rather fruitless with regards to solubility as well as to renin inhibitory activity. Octapeptide-carbinol derivative, prolylphenylalanylhistidylleucylleucylvalyltyrosyl-serinol was synthesized, whose dihydrochloride was moderately soluble in water and exhibited the highest renin inhibitory activity among the compounds tested throughout this series of work.抄録全体を表示PDF形式でダウンロード (1363K) -
塩川 洋一, 大木 貞雄1973 年 21 巻 5 号 p. 981-988
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーCycloaddition reactions of 2-azido-1-methylbenzimidazole (I) with such reagents as diphenylketene, dimethyl acetylenedicarboxylate, methyl propiolate, and N, N-diethyl-phenylethynylamine were investigated. The diester exclusively reacted with the carbonnitrogen double bond of imidazole ring to give the 1 : 1 molar adduct (IV). On the other hand, the ynamine added to azido group at C2-position and only triazole derivative (XI) was obtained. For thermal decomposition of the adduct (XI), the presence of 2-azirine compound (XIX), a four electron system, as intermediate was assumed from consideration of structures of the decomposition products (XII and XIII). Reaction of I with the ester gave a mixture of the triazolo derivative (VI) as major product and the 1 : 1 molar adduct (VII). Also, diphenylketene exothermically reacted with I and gave 2, 3-dihydro-9-methyl-3-oxo-2, 2-diphenyl-9H-imidazo[1, 2-a] benzimidazole (II).抄録全体を表示PDF形式でダウンロード (1028K) -
友田 正司, 田中 真知子1973 年 21 巻 5 号 p. 989-994
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPlantasan, the seed mucilage of Plantago major L. var. asiatica DECAISNE, has been subjected to partial acid hydrolysis, and three disaccharides were obtained. Analysis of components, periodate oxidation, methylation and enzymic degradation studies provided the evidences that they are O-β-D-xylopyranosyl-(1→2)-D-xylopyranose, O-β-D-xylopyranosyl-(1→4)-D-xylopyranose, and O-β-D-glucopyranosyl-uronic acid-(1→5)-L-arabino-furanose.抄録全体を表示PDF形式でダウンロード (834K) -
園 正憲, 早津 彦哉1973 年 21 巻 5 号 p. 995-1000
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーAs an extension of the work on the permanganate oxidation and the oxygen-mediated bisulfite reaction of 4-thiouridine, the reactions of 2-thiouracil were studied. On treatment with a stoichiometric amount of permanganate at pH 7 and 0°, 2-thiouracil yielded uracil-2-sulfonate. The sulfonate was susceptible to hydrolysis with weak acid but was stable in alkali. Kinetic studies of the acid hydrolysis were carried out. 2-Thiouridine also underwent a rapid oxidation on treatment with permanganate under similar conditions. Uridine and a small amount of uracil were detected as the products of the reaction of the nucleoside, suggesting that the intermediate uridine-2-sulfonate is more susceptible to hydrolysis compared with uracil-2-sulfonate. Treatment of 2-thiouracil with dilute bisulfite at pH 7 and room temperature under oxygen-bubbling resulted in quantitative formation of uracil-2-sulfonate. The mechanism of the reaction involves action of the free radicals generated during the autoxidation of bisulfite, a mechanism already had been described in the bisulfite reaction with 4-thiouridine.Oxygen-mediated bisulfite reaction with 2-thiouridine was shown to be complex, yielding not only uridine but also other products including an appreciable amount of uracil.抄録全体を表示PDF形式でダウンロード (820K) -
飯田 英夫, 許 弘卿, 菊地 豊彦1973 年 21 巻 5 号 p. 1001-1004
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーBischler-Napieralski reaction of phenolic bromo amide (VIII), which was obtained from the Schotten-Baumann reaction of 4-benzyloxy-2-bromo-5-hydroxyphenethylamine (VI) with 2-bromo-4, 5-dimethoxyphenylacetyl chloride (VII) and then reduction with NaBH4 of the resultant dihydroisoquinoline (IX) gave 7-benzyloxy-5-bromo-1-(2-bromo-4, 5-dimethoxybenzyl)-8-hydroxy-1, 2, 3, 4-tetrahydroisoquinoline(X). N-Methylation of X afforded XI. The Ullmann reaction of XI in the presence of potassium carbonate and cupric oxide in pyridine gave 6-benzyloxy-4-brome-1-methyl-9, 10-dimethoxy-1, 2, 3, 12, 12a-pentahydrobenzoxepino[2, 3, 4-i, j]isoquinoline (XII). Subsequent debenzylation and debromination of XII with hydrogen over 10% palladium-charcol gave dl-cularidine (Id) which was identified with natural cularidine by infrared and nuclear magnetic resonance spectral comparisons.抄録全体を表示PDF形式でダウンロード (535K) -
広瀬 徳康, 栗山 鎮雄, 左右 田茂, 坂口 健哉, 山本 ひろみ1973 年 21 巻 5 号 p. 1005-1013
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーA series of 1- or 3-substituted spiro[cycloalkane-1', 2(1H)quinazolin]4(3H)-ones and the related compounds were synthesized for pharmacological testing. They could be prepared via anthranilic acid N-substituted amides or N-substituted anthranilamides with appropriate ketones, but attempts for introduction of the substituents at 1 or 3 position of spiro[cyclohexane-1', 2(1H)quinazolin]-4(3H)-one were failed. Mass fragmentation pathways are described for the several representative compounds briefly.抄録全体を表示PDF形式でダウンロード (1041K) -
西川 嘉廣, 道下 一彦, 黒野 吾市1973 年 21 巻 5 号 p. 1014-1019
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーThe low molecular weight carbohydrate constituents of eight species of lichens (Cetraria islandica, Cladonia crispata, C. rangiferina, C. squamosa, Peltigera aphthosa, P. nigripunctata, Umbilicaria caroliniana, and Usnea rubescens) have been analysed as their acetyl, trifluoroacetyl, and trimethylsilyl derivatives by gas chromatography. Glycerol, erythritol, ribitol, arabinitol, mannitol, fructose, glucose, sucrose, and trehalose were detected commonly in these lichens. In addition, the occurrence of 3-O-β-D-glucopyranosyl-D-mannitol in P. aphthosa and P. nigripunctata and of 2-O-β-D-galactofuranosyl-D-arabinitol (umbilicin) in C. islandica and U. caroliniana have been found.抄録全体を表示PDF形式でダウンロード (840K) -
野中 源一郎, 小寺 喜子, 西岡 五夫1973 年 21 巻 5 号 p. 1020-1026
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーThe structure (I) of a new alkaloid, corydalic acid methyl ester, mp 140-141°, [α]D+85.4°, C22H23O6N, isolated from Corydalis incisa PERS. (Papaveraceae) only in the vegetative stage, was established by the spectroscopic studies and chemical correlation with mesotetrahydrocorysamine. Furthermore, on the basis of the stereochemical investigation of mesotetrahydrocorysamine, the stereostructure of corydalic acid methyl ester was determined as XII. Corydalic acid methyl ester is a noteworthy natural alkaloid in which aromatic ring is attached to the position-3 of the tetrahydroisoquinoline, and biogenetically it is supposed to be derived from protoberberine skeleton by a fission of B-ring, possibly through an aldehyde-type intermediate.抄録全体を表示PDF形式でダウンロード (828K) -
石墨 紀久夫, 森 和夫, 稲葉 茂穗, 山本 久夫1973 年 21 巻 5 号 p. 1027-1030
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーChromic acid oxidation of N-phthalimidoacetylindoles (4) caused cleavage of the indole 2, 3-double bond affording the expected 2'-benzoyl-2-phthalimidoacetanilides (5). Ozonolysis, on the other hand, resulted in the formation and isolation of the stable crystalline ozonides (6). Ozonides (6) as well as 5 were shown to be converted into benzodiazepin-2-one (7) by treatment with hydrazine hydrate.抄録全体を表示PDF形式でダウンロード (615K) -
島田 和武, 藤井 洋一, 南原 利夫1973 年 21 巻 5 号 p. 1031-1036
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーIn order to obtain the more potent cardiotonic drug digitoxigenin 3-suberoylpeptides whose peptide moieties are derived from the partial structure of kinin, have been synthesized. Some of the desired compounds were prepared from digitoxigenin 3-suberoyl-p-nitrophenol (I) by direct condensation with the pertinent di- or tri-peptide. As for the steroidal peptides having the readily unavailable amino acid sequence the stepwise method involving the repeated p-nitrophenyl ester formation was carried out. The condensation reaction of p-nitrophenyl ester with amino acid or peptide was considerably improved in respect with the yield, when the amino group was activated by leading to the carbamate.抄録全体を表示PDF形式でダウンロード (853K) -
神谷 和秀, 和田 喜一, 野村 容朗, 西川 正夫, 森本 至郎1973 年 21 巻 5 号 p. 1037-1041
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーThe absolute configuration of (-)-α-sulfophenylacetic acid (II), the side chain acid of a novel antipseudomonal semisynthetic penicillin, (-)-α-sulfobenzylpenicillin (I), has been determined and confirmed to be in the D-series. Accordingly, the biologically more active diastereoisomer which is derived from II has been assigned to be D(-)-α-sulfobenzylpenicillin.抄録全体を表示PDF形式でダウンロード (596K) -
EUGENE L. PARROTT, ROBERT J. BRAUN1973 年 21 巻 5 号 p. 1042-1046
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーUsing micellar diffusion coefficients calculated by means of dissolution-rate and solubility measurements, the Stokes-Einstein equation was employed to estimate the relative micelle size and the micellar weight of benzoic acid-micelle species in solutions of polysorbate 80. The necessity of considering the relative viscosity of the micellar solutions and the variance of diffusion coefficients with concentration was demonstrated. Under the experimental conditions described it does not seem justifiable to use the Stokes-Einstein equation in the determination of micellar weight and/or size.抄録全体を表示PDF形式でダウンロード (583K) -
加藤 鉄三, 山本 豊, 武田 四郎1973 年 21 巻 5 号 p. 1047-1052
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーThe reaction of diketene with ketene acetals (Ia-f) has been studied on cycloaddition reaction to form 4-pyrone derivatives (II and III). Cyanoketene diethylacetal reacted with diketene to give 3-cyano-4-ethoxy-6-methy1-2-pyrone besides the formation of IIIf. IIa, b and IIIa, b, c, d, f were converted in good yields to corresponding 2-ethoxy-6-methyl-3-substituted-4-pyridone (V), respectively, whereas VI was converted to VIII and IX by treatment with ammonia.抄録全体を表示PDF形式でダウンロード (698K) -
塩谷 俊作, 米谷 正1973 年 21 巻 5 号 p. 1053-1060
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーNew synthetic routes of 3-methyl-2, 3, 4, 5, 6, 7-hexahydro-2, 7-methano-1H-3-benzazonine (A) and 4-methyl-2, 3, 4, 5, 6, 7-hexahydro-1, 6-methano-1H-4-benzazonine (B) were described. A Schmidt reaction of ethyl 2-oxo-5-phenylcyclohexanecarboxylate (I) gave the corresponding lactam (II), which in turn was reduced with lithium aluminum hydride to afford 2-hydroxymethyl-4-phenyl-2, 3, 4, 5, 6, 7-hexahydro-1H-azepioe (III). The N-ben-zoyl derivative (IV) of III was oxidized with dimethylsulfoxide and dicyclohexylcar-bodiimide to give the corresponding aldehyde (V), which was submitted to oxidation with silver hydrodde to give N-benzoyl-4-phenyl-2, 3, 4, 5, 6, 7-hexahydro-1H-azepine-2-carboxylic acid (VI). Cyclization of VI by heating with polyphosphoric acid yielded 2, 3, -4, 5-tetrahydro-2, 7-methano-1H-3-benzazonin-7(6H)-one (VII). A Wolff-Kishner reduction and the successive N-methylation gave the final compound A. While, Wolff-Kishner reduction of the N-methyl derivative (IX) of VII gave an elimination product, 1-(N-methylaminopropyl)-1, 2-dihydronaphthalene (XI) . Treatment of 4-(N, N-dimethylaminoethyl)-3, 4-dihydronaphthalen-1(2H)-one (XII) with ethyl chlorocarbonate afforded a carbamate, 4-(N-methyl-N-ethoaycarbonylaminoethyl)-3, 4-dihydro-naphthalen-1(2H)-one (XIII), which was hydrolized, followed by a Mannich reaction with formaldehyde to yield 4-methyl-2, 3, 4, 5-tetrahydro-1, 6-methano-1H-4-benzazonin-7(6H)-one (XV). Reduction of the ketone XV with lithium aluminum hydride or by catalytic hydrogenation over Adams' catalyst gave the corresponding hydroxyl derivative (XVI), which was reduced with hydriodic acid and red phosphorus to give the final compound B.抄録全体を表示PDF形式でダウンロード (1044K) -
原山 尚, 大谷 光昭, 沖 正信, 犬伏 康夫1973 年 21 巻 5 号 p. 1061-1068
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーIn connection with the synthesis of serratinine (A), the selective cyclization reaction of the 1, 2-cyclohexanediacetaldehyde derivatives, IIIa and IITb, through the intramolecular aldol condensation reaction was investigated. Cyclization reaction of IIIa or IITb by basic alumina or by the enamine method2) using piperidine acetate in dry benzene gave selectively IVa or IVb. On the other hand, cyclization reaction of IIIa or IIIb using excess pyrrolidine acetate in abs. MeOH afforded selectively Va or Vb which is suitable for the present purpose.抄録全体を表示PDF形式でダウンロード (1106K) -
小林 優, 三橋 博1973 年 21 巻 5 号 p. 1069-1075
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーThe reaction of nitrous acid with steroidal amides (I, VII, IX and X), α, β-unsturated ε-lactams (XIX and XXI), and enamine-type lactams (XXIV, XXVIII, XXX and XXXI) was studied. The amides mainly gave esters in low or modest yield with retention of the configuration. The α, β-unsaturated lactams gave N-nitroso-lactams quantitatively. The enamine-type δ-lactams gave oximino-δ-lactams in a high yield.抄録全体を表示PDF形式でダウンロード (1097K) -
長谷 純一, 小橋 恭一, 小林 玲子1973 年 21 巻 5 号 p. 1076-1079
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーInvestigations were performed on the correlation between the inhibitory power on Na+, K+-ATPase activity of phlorizin, asebotin, coreopsin, naringin-and hesperidin-chalcone and their chemical structure. Both chalcone and dihydrochalcone inhibited Na+, K+-ATPase activity, depending upon the number and position of phenolic hydroxyl group in their carbon skeleton. Free hydroxyl group at 4' position of phlorizin played an important role in the inhibitory power.抄録全体を表示PDF形式でダウンロード (524K) -
柳沢 宏明, 中尾 英雄, 安東 秋子1973 年 21 巻 5 号 p. 1080-1089
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーSulfonamide or phosphonic acid analogs of oxolinic acid (I) and nalidixic acid (II), in which the carboxyl groups of I and II were replaced by sulfamoyl and phosphono groups, were synthesized conveniently by the modification of the Camps'es quinoline synthesis. They were evaluated for antimicrobial activity but no significant activity was noted.抄録全体を表示PDF形式でダウンロード (1259K) -
平井 功一, 松田 秀文, 岸田 有吉1973 年 21 巻 5 号 p. 1090-1095
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーAttempts were made to prepare sulfur substituted 2-azetidinones by the reaction of vinylsulfide with chlorosulfonyl isocyanate (CSI). The main product of the reaction of β-methylthiostyrene (I) with CSI was pyridone derivative (II), but in the case of 1-phenylthio-1-propene (V) the main products were dihydrouracil derivatives (VI and VII) and acrylic acid derivatives (VIII and IX). Reaction of 1-p-chloro- or p-methylphenylthio-1-propene (Xa and b) with CSI in dry ether at -30°gave the desired 2-azetidinone (β-lactam) derivatives (XIa and b) in 63 and 66.4% isolated yield respectively.抄録全体を表示PDF形式でダウンロード (742K) -
高尾 楢雄, / 高尾 佐知子, SACHIKO TAKAO1973 年 21 巻 5 号 p. 1096-1102
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーEs wird die Struktur des (+)-14-Epicorynolins, das provisorisch als Base II gezeichnet wurde, ein neues Alkaloid aus Corydalis incisa beschrieben. Das Des-N-Produkt (9) der Base II, das durch die aweimaligen Emde-Abbauen erhalten wurde, stimmt mit der optisch aktiven Form des Des-N-Produkts (7) des Corynolins uberein. Base II stimmt weder mit Corynolin (1) noch mit 11-Epicorynolin (3) uberein. Die aus Base II abgeleitete Anhydrobase (6) erwies sich als nicht identisch mit der optisch aktiven Anhydrobase (5) des Corynolins. Daher wurde festgestellt, dass die Verknupfungsweise der Ringe B und C in der Base II trans sein muss. (+)-14-Epicorynolin stellt den ersten Beispiel der Benzo(c)-phenanthridintyp-Alkaloide mit der trans-Verknupfung der Ringe B und C dar, die in der Natur vorkommen.抄録全体を表示PDF形式でダウンロード (1036K) -
須見 泰子, 亀谷 富士夫1973 年 21 巻 5 号 p. 1103-1107
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーTwo of five isomers of 2, 3, 5, 6-tetramethyl-1, 4-dioxane were isolated. Their configurations were assigned with the coupling constants of the methine protons of the 1, 4-dioxane ring by nuclear magnetic resonance (NMR) spectrometry. 2, cis-3-Bis(Iodomethyl)-cis-5, trans-6-dimethyl-1, 4-dioxane (IIa) and 2, trans-3-bis-(iodomethyl)-trans-5, cis-6-dimethyl-1, 4-dioxane (IIb) were obtained by the cyclization reaction of meso- and dl-2, 3-butanediol, respectively, and 1, 3-butadiene with mercuric oxide and iodine. 2, cis-3, cis-5, trans-6-Tetramethyl-1, 4-dioxane (IIIa) and 2, trans-3, trans-5, cis-6-tetramethyl-1, 4-dioxane (IIIb) were obtained by reduction of IIa and IIb, respectively, with LiAlH4. The coupling constants and τ values of the methine protons of the 1, 4-dioxane ring were 3.3, 9.0 Hz, 6.16, 6.30, 6.54, 6.76 τ for IIIa, and 9.0 Hz, 6.77 τ for IIIb.抄録全体を表示PDF形式でダウンロード (561K) -
西部 三省, 久田 末雄, 稲垣 勲1973 年 21 巻 5 号 p. 1108-1113
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーA new lignan glucoside named nortracheloside (IV), C26H32O12·H2O, mp 95-100°, was isolated from the stems of Trachelospermum asiaticum NAKAI var. intermedium NAKAI (Apocynaceae). The lignan derivatives were prepared from tracheloside (III) and nortracheloside (IV). From the discussion of mass spectra of the lignan derivatives, the structures of III and IV were established as 8(S), 8'(S)-4', 8'-dihydroxy-3, 4, 3'-trimethoxy-lignan-olid(9, 9')4'-β-D-glucopyranoside and 8(S), 8'(S)-4, 4', 8'-trihydroxy-3, 3'-dimethoxy-lignan-olid(9, 9')4'-β-D-glucopyranoside, respectively.抄録全体を表示PDF形式でダウンロード (767K) -
西部 三省, 久田 末雄, 稲垣 勲1973 年 21 巻 5 号 p. 1114-1117
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーA new lignan diglucoside was isolated from the stems of Trachelospermum asiaticum NAKAI var. intermedium NAKAI (Apocynaceae) and its structure was established as nortrachelogenin-4, 4'-di-O-β-D-glucopyranoside (I). Also the presence of α-conidendrin glucoside was suggested.抄録全体を表示PDF形式でダウンロード (628K) -
小林 義郎, 熊懐 稜丸, 関根 安男, 久津間 輝雄1973 年 21 巻 5 号 p. 1118-1123
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーThe 1, 3-dipolar cycloaddition of dicyanoacetylene (IIb) to isoquinolinium ylides did not give the primary adduct but the aromatized and/or isomerized products. Further, in the reaction of isoquinolinium bis(methoxycarbonyl)methylide (Ia), possibly a rearranged addition product, 1, 10b-dihydropyrrolo[2, 1-α]isoquinoline (VII), was obtained beside 2, 3-dihydropyrrolo[2, 1-α]isoquinoline (Va) and pyrrolo[2, 1-α]isoquinoline (VIa). In the reaction of isoquinolinium cyano(methoxycarbonyl)methylide (Ib), 2, 3-dihydropyrrolo[2, 1-α]isoquinoline (VIII), formed by the liberation of a methoxycarbonyl group, was obtained in addition to VIa and pyrrolo[2, 1-α]isoquinoline-1, 2, 3-tricarbonitrile (VIb).抄録全体を表示PDF形式でダウンロード (758K) -
亀谷 哲治, 田口 栄子, 八巻 一弥, 小塚 厚人, 照井 恒一1973 年 21 巻 5 号 p. 1124-1126
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (464K) -
古川 潮, 小島 洋子, 林 清五郎1973 年 21 巻 5 号 p. 1126-1131
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (820K) -
長瀬 弘始1973 年 21 巻 5 号 p. 1132-1135
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (544K) -
寺島 孜郎, 高島 克己, 佐藤 忠夫, 山田 俊一1973 年 21 巻 5 号 p. 1135-1139
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (804K) -
田村 恭光, 隅田 芳男, 玉田 重晴, 池田 正澄1973 年 21 巻 5 号 p. 1139-1142
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (598K) -
山崎 晤弘, 秋山 征男, 熊代 泉, 池原 森男1973 年 21 巻 5 号 p. 1143-1146
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (638K) -
林 時司, 河合 聡, 大野 武男1973 年 21 巻 5 号 p. 1147-1151
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (627K) -
菊川 清見, 市野 元信1973 年 21 巻 5 号 p. 1151-1155
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (607K) -
西部 三省, 久田 末雄, 稲垣 勲1973 年 21 巻 5 号 p. 1155-1157
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (506K) -
山竹 美和, 加藤 仁, 高木 敬次郎1973 年 21 巻 5 号 p. 1157-1160
発行日: 1973/05/25
公開日: 2008/03/31
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塩谷 俊作, 米谷 正1973 年 21 巻 5 号 p. 1160-1163
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (630K) -
藤原 靖弘, 木本 正七郎, 岡本 正夫1973 年 21 巻 5 号 p. 1166-1167
発行日: 1973/05/25
公開日: 2008/03/31
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吉村 英敏, 山本 弘明1973 年 21 巻 5 号 p. 1168-1169
発行日: 1973/05/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (420K)
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