巻号一覧
51 巻, 8 号
選択された号の論文の26件中1～26を表示しています
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Regular Articles
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Katsumasa Aoki, Yoshinobu Ishikawa, Miyuki Oyama, Yoshikazu Tomisugi, ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 899-903
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーA series of tentacle porphyrins having four aminoalkyl groups at the periphery was synthesized, and the DNA binding properties were investigated by absorption and circular dichroism (CD) spectroscopic methods. The aminopropyl chain was found to facilitate binding, and bisignate induced CD spectra revealed that the porphyrins are self-stacked on the DNA surface. The photonuclease activity of the tentacle porphyrins was also studied, and the aminopropylporphyrin showed the highest activity. The activity increased in proportion to the porphyrin load, but higher loads resulted in the decrease of activity. This inhibitory step corresponded to aggregation of the porphyrin. Thus, the aggregation was suggested to shield the inner porphyrin from the solvent, the production of active oxygen species being suppressed.抄録全体を表示PDF形式でダウンロード (182K) -
Yorinobu Yonezawa, Sumio Ishida, Hisakazu Sunada原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 904-908
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーTo obtain basic and clear release properties, wax matrix tablets were prepared from a physical mixture of drug and wax powder at a fixed mixing ratio. Properties of release from the single flat-faced surface, curved side surface, and/or whole surface of the wax matrix tablet were examined. Then tortuosity and the applicability of Higuchi's square-root time law equation were examined. The Higuchi equation well analyzed the release processes of different release manners. However, the region fitted to the Higuchi equation differed with the release manner. Tortuosity obtained with release from the single flat-faced surface and curved side surface was comparable with that obtained with the release from a reservoir device tablet, whereas tortuosity obtained with release from the whole surface was larger. As the wax matrix tablets were prepared at a fixed mixing ratio, their internal structures should be similar. Therefore changes in the matrix volume or volume fraction with release were examined, and an extra volume where dissolved drug stray becomes large with release time in the case of release from the whole surface. These factors should be taken into account for evaluation of applicability and release properties. Furthermore, the entire release process should be analyzed using a combination of the square-root time law and other suitable equations in accordance with release manner or condition.抄録全体を表示PDF形式でダウンロード (100K) -
Kinzo Watanabe, Miyuki Sekine, Kazuo Iguchi原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 909-913
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーThree marine prostanoids, 1, 2, and 3, were isolated from the extract of the Okinawan soft coral Clavularia viridis. The structures of these compounds were assigned based on the results of spectroscopic analysis. Compound 1 was shown to be preclavulone-A methyl ester, and this is the first isolation of the ester of preclavulone-A as a natural product. Preclavulone-A is proposed to be the key intermediate in the biosynthesis of marine prostanoids exemplified by clavulones in C. viridis. The new prostanoid 3 was suggested to be a biosynthetic intermediate from preclavulone-A to clavulones, and a possible biogenetic pathway via 3 is proposed.抄録全体を表示PDF形式でダウンロード (83K) -
Laura Ribeiro, Thorsteinn Loftsson, Domingos Ferreira, Francisco Veiga原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 914-922
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーThe purpose of this study was to investigate the interactions between vinpocetine (VP), sulfobutyl ether beta-cyclodextrin (SBEβCD) and the water-soluble polymers polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC). The water-soluble polymers were shown to improve the complexation efficiency of SBEβCD, and thus less SBEβCD was needed to prepare solid VP–SBEβCD complexes in the presence of the polymers. The interactions between VP and SBEβCD, with or without PVP or HPMC, were thoroughly investigated in aqueous solutions using the phase-solubility method as well as in the solid state. The amount of VP solubilized in water or aqueous polymer solution increased linearly with increasing SBEβCD concentration, demonstrating AL-type plots. We estimated the apparent stability constant (Kc) at room temperature of VP–SBEβCD binary complex to be 340 M−1 and this value increased to 490 M−1 or 390 M−1, respectively, with the addition of PVP and HPMC, assuming a 1 : 1 VP–SBEβCD molar ratio. Improvement in the Kc values for ternary complexes clearly confirmed the benefit of the addition of water-soluble polymers to promote higher complexation efficiency. Solid VP–SBEβCD binary and ternary systems were prepared by physical mixing, kneading, coevaporation, and lyophilization methods and fully characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray diffractometry. The results obtained suggest that coevaporation and lyophilization methods yield a higher degree of amorphous entities and indicated formation of VP–SBEβCD binary and ternary complexes.抄録全体を表示PDF形式でダウンロード (411K) -
Hiroyuki Nojima, Mayuko Takeda-Shitaka, Youji Kurihara, Kenshu Kamiya, ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 923-928
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーClass II major histocompatibility complex (MHC) has tolerance for binding longer antigen peptides than those bound by class I MHC. In this paper, a normal mode analysis on HLA-DR1 class II MHC involving an antigen peptide indicated that the peptide-binding groove had some different dynamic characteristics from that of HLA-A2 class I MHC. The dynamic changes in the class I groove with removal of the bound peptide were limited primarily to the central region and the C-terminal side (corresponding to the C-terminal side of the bound peptide) of the groove, while the dynamic changes in the class II groove with removal of the bound peptide extended to the whole of the groove, and were especially remarkable around a strand located in the N-terminal side (corresponding to the N-terminal side of the bound peptide) of the groove. These results suggest that the N-terminal side of the class II groove is more flexible than the same side of the class I groove, and this flexibility may allow some N-terminal residues of the bound peptide to extend outside the class II groove. Definite anti-correlative motions with removal of the bound peptide appeared between two α-helical regions of class II MHC as in the case of class I MHC. These motions of the class II groove may play an important role in obtaining “a flexible dynamic fit” against diverse longer peptides both of whose terminals extend outside the groove.抄録全体を表示PDF形式でダウンロード (219K) -
María Luisa Jimeno, Ibon Alkorta, Carolina Cano, Nadine Jagerov ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 929-934
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーThe oxalate salts and free bases of fentanyl and N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide, a new lead compound for long-acting analgesia, have been characterized by 1H- and 13C-NMR spectroscopy. The crystal structure of the hydrochloride of N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide monohydrate has been determined. Two centrosymmetrically related cations, joined through C(phenyl)-H…π contacts, encapsulate a large void that contains pairs of anions and bridged water molecules into a zero-dimensional (0D) supramolecular motif. The cations are linked to this framework via N+H…Cl− contacts. GIAO/B3LYP calculations have been carried out to compare the experimental 13C chemical shifts with the absolute shieldings thus calculated. The protonation of both molecules takes place on the piperidine ring (axial protonation), as has been verified both in the solid state (X-ray) and in solution (NMR).抄録全体を表示PDF形式でダウンロード (109K) -
Li-Yan Wang, Nai-Li Wang, Xin-Sheng Yao, Syohei Miyata, Susumu Kitanak ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 935-941
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーFour new ingenane-type diterpenes, 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-acetylingenol (1), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-deoxyingenol (2), 3-O-(2E,4Z-decadienoyl)-20-deoxyingenol (3), and 3-O-(2E,4E-decadienoyl)-20-deoxyingenol (4), two new jatrophane-type diterpenes, kansuinins D (9) and E (10), and four known ingenane-type diterpenes were isolated from the root of Euphorbia kansui. Their structures were elucidated by spectroscopic and chemical analysis, and individual Xenopus cells at the blastular stage were cultured with the diterpenes to test for biological activity. 20-Deoxyingenol diterpenes 3 and 4 induced the greatest cell cleavage arrest (0.5 μg/ml of each compound resulted in >75% cleavage arrest), but cell cleavage inhibitory activity became weak when C-16 had an acyl residue. In contrast, the jatrophane diterpene kansuinin D (9) showed no activity.抄録全体を表示PDF形式でダウンロード (85K) -
Toshihiro Shimizu, Yoshinori Nakano, Shuji Morimoto, Tetsuro Tabata, N ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 942-947
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーLansoprazole fast-disintegrating tablet (LFDT) is a new patient-friendly formulation of lansoprazole. Since lansoprazole is an antiulcer agent and is unstable under acidic conditions, we have developed LFDT as an orally disintegrating tablet containing enteric-coated microgranules. The effect of compression on dissolution behavior was investigated, as compression affected cleavage and crushing of the enteric layer. To decrease cleavage and crushing of the enteric layer, the effects of the combined ratio of methacrylic acid copolymer dispersion to ethyl acrylate–methyl methacrylate copolymer dispersion and the concentration of triethyl citrate on the dissolution in the acid stage and the dissolution in the buffer stage were evaluated. By adjusting the ratio of methacrylic acid copolymer dispersion to ethyl acrylate–methyl methacrylate copolymer dispersion to 9 : 1 and adding a 20% triethyl citrate concentration, sufficient flexibility of the enteric layer and sufficient stability against compression forces were achieved. Agglomeration of enteric-coated microgranules during the coating process was decreased at the optimized concentration of triethyl citrate and glyceryl monostearate. We compared the absorption properties of LFDT and lansoprazole capsules in dogs. The absorption profiles of LFDT were similar to those of lansoprazole capsules.抄録全体を表示PDF形式でダウンロード (80K) -
Tian-Shung Wu, Dau-Min Lin, Li-Shian Shi, Amooru Gangaiah Damu, Ping-C ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 948-950
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーFrom the stems of Rubia wallichiana DECNE, thirty-four structurally related compounds were isolated and identified. Three of them, namely rubiawallin-A (1), -B (2), and -C (3), constitute the first report of their occurrence from the natural source. Their structures were determined by comprehensive analyses of their 1D and 2D NMR, and electron impact (EI) mass spectral data. Furthermore, an in vitro screening of cytotoxicity of the isolated compounds was also evaluated. Among the testing compounds, 1-hydroxy-2-hydroxymethyl-3-methoxyanthraquinone (4) demonstrated most effective cytotoxicity towards Hepa-3B and Colo-205 cells.抄録全体を表示PDF形式でダウンロード (57K) -
Takashi Itoh, Kazuhiro Nagata, Masashi Yokoya, Michiko Miyazaki, Keiko ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 951-955
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーChiral 1-substituted isoquinoline derivatives, which were obtained by the reaction using alanine derivatives as chiral auxiliaries, were transformed to (S)-2,3,9,10,11-pentamethoxyhomoprotoberberine (7) and a synthetic intermediate for O-methylkreysigine (9) in good yields and high stereoselectivity. The corresponding chiral allyl derivative of isoquinoline was transformed to a pyrrolidinoisoquinoline (16) in a highly enantioselective manner.抄録全体を表示PDF形式でダウンロード (91K) -
Makiko Nishida, Hitoshi Yoshimitsu, Masafumi Okawa, Toshihiro Nohara原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 956-959
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーFour new cycloartane glycosides, named aquilegiosides G—J, were isolated from the dried aerial parts of Aquilegia vulgaris. Their structures were determined by spectroscopic analysis and chemical evidence.抄録全体を表示PDF形式でダウンロード (74K) -
Yoshihiro Mimaki, Minpei Kuroda, Akihito Yokosuka, Hiroshi Harada, Mas ...原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 960-965
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーTo characterize the stems of Akebia trifoliata chemically, a detailed phytochemical examination was carried out on A. trifoliata stems, with particular attention to the triterpene and triterpene saponin constituents, and resulted in the isolation of three new triterpenes (1—3) and three new triterpene saponins (11—13), together with seven known triterpenes (4—10) and 12 known triterpene saponins (14—25). The structures of the new compounds were determined on the basis of spectroscopic analysis, including two-dimensional NMR spectroscopic data, and the results of hydrolysis. Four saponins (22—25), which were obtained in good yields and were not isolated from Akebia quinata stems, are concluded to be applicable as marker compounds in chemically distinguishing between A. trifoliata and A. quinata by conventional TLC examination. To the best our knowledge, the current work is the first chemical investigation of A. trifoliata.抄録全体を表示PDF形式でダウンロード (96K) -
Tsuyoshi Satoh, Tatsuya Sakamoto, Masanori Watanabe, Koji Takano原稿種別: Regular Article
専門分野: [not specified]
2003 年 51 巻 8 号 p. 966-970
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーTreatment of 1-chlorovinyl p-tolyl sulfoxides, which were synthesized from ketones and chloromethyl p-tolyl sulfoxide, with ethylmagnesium chloride or isopropylmagnesium chloride at below −78 °C gave magnesium alkylidene carbenoids in about 90% yields. The reaction of the generated carbenoids with lithium α-sulfonyl carbanions was found to afford tri- and tetra-substituted allenes. Both cyclic ketones and acyclic ketones were useful in this procedure. However, the 1-chlorovinyl p-tolyl sulfoxides derived from aldehydes gave only rearranged products, acetylenes, under the reaction conditions. The magnesium alkylidene carbenoid derived from an optically active 1-chlorovinyl p-tolyl sulfoxide was treated with lithium α-carbanion of 1-naphthyl phenyl sulfone; however, the obtained allene was found to be racemic. The mechanism of this reaction is also discussed.抄録全体を表示PDF形式でダウンロード (97K)
Notes
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Carmela Saturnino, Mariafrancesca Buonerba, Gianpiero Boatto, Maria Pa ...原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 971-974
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーThe therapy of human cancer is one of the more pursued goals by medicinal chemistry research. Most of the compounds clinically used as a treatment owe their efficacy to their cytotoxic interaction (direct or indirect) with nuclear DNA. This interaction results in the inhibition of DNA synthesis and the degradation of nucleic strands. Ellipticine is a naturally occurring 6H-pyrido[4,3-b]carbazole alkaloid endowed with antitumor activity, and several ellipticine derivatives have been used in clinical trials. We previously reported some 1,4-dimethyl-9H-carbazole derivatives structurally related to ellipticine. The purpose of our research was to transform the pyridocarbazole in a prodrug so that it would have more penetration in the tumor cells and block their replication. Our prodrug is slowly hydrolyzed in human plasma in the corresponding acid. From these preliminary results, we deduce that our compound can block cellular replication. Our hypothesis is that the antitumoral activity is probably related to the induction of damage to DNA, without cellular lysis in the short term.抄録全体を表示PDF形式でダウンロード (123K) -
Laura Hernández Franco, Jorge Alejandro Palermo原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 975-977
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーThe synthesis of 2-substituted isomers of the meridianins, a familiy of bioactive indole alkaloids isolated from the tunicate Aplidium meridianum, was undertaken. The synthetic route comprises six steps, with a microwave promoted Fischer cyclization as the key reaction.抄録全体を表示PDF形式でダウンロード (61K) -
Muniyandy Saravanan, Kalakonda Sri Nataraj, Kettavarampalayam Swaminat ...原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 978-983
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーThe object of this study was to develop hydroxypropyl methylcellulose (HPMC) based cephalexin extended release tablet, which can release the drug for six hours in predetermined rate. Twenty-one batches of cephalexin tablets were prepared by changing various physical and chemical parameters, in order to get required theoretical release profile. The influences of HPMC, microcrystalline cellulose powder (MCCP), granulation technique, wetting agent and tablet hardness on cephalexin release from HPMC based extended release tablets were studied. The formulated tablets were also characterized by physical and chemical parameters. The dissolution results showed that a higher amount of HPMC in tablet composition resulted in reduced drug release. Addition of MCCP resulted in faster drug release. Tablets prepared by dry granulation was released the drug slowly than the same prepared with a wet granulation technique. Addition of wetting agent in the tablets prepared with dry granulation technique showed slower release. An increase in tablet hardness resulted in faster drug release. Tablets prepared with a wet granulation technique and having a composition of 9.3% w/w HPMC with a hardness of 10—12 kg/cm2 gave predicted release for 6 h. The in vitro release data was well fit in to Higuchi and Korsmeyer–Peppas model. Physical and chemical parameters of all formulated tablets were within acceptable limits. One batch among formulated twenty-one batches was successful and showed required theoretical release. The effect of storage on in vitro release and physicochemical parameters of successful batch was studied and was found to be in acceptable limits.抄録全体を表示PDF形式でダウンロード (92K) -
Alaa Mohamed Nafady, Mohamed Ahmed El-Shanawany, Mahmoud Hamed Mohamed ...原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 984-985
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーBy using β-cyclodextrin-inclusion as a unique technique, an efficient separation of pharmacologically active phenolic compounds from Brazilian propolis was achieved to provide one new compound, 3-(3-hydroxy-3-methyl-butyl)-5-prenyl-4-hydroxycinnamic acid, together with two common cinnamic acid derivatives, artepillin C and capillartemisin A, and two known flavanols, aromadendrin and 3,5,7-trihydroxy-4′-methoxyflavanol.抄録全体を表示PDF形式でダウンロード (47K) -
Yueh-Hsiung Kuo, Chiou-Fung Chyu, Hsiu-Chuan Lin原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 986-989
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーFive new cadinane-type sesquiterpenes, 15-acetoxy-T-muurolol (1), isokhusinodiol (2), cadin-10(14)-ene-4β,5α-diol (3), cadinane-4β,5α,10β-triol (4), and muurolane-4β,5β,10β-triol (5), together with five known compounds, T-cadinol (6), T-muurolol (7), α-cadinol (8), δ-cadinol (9), and khusinodiol (10), were isolated from the roots of Taiwania cryptomerioides. The structure of the new constituents were elucidated through chemical and spectral studies.抄録全体を表示PDF形式でダウンロード (69K) -
Thirumani Venkateshwar Goud, Masuna Srinivasulu, Vanimireddy Lakshmi N ...原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 990-993
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーTwo new bromotyrosine-derived metabolites (1, 2) have been isolated along with the known compounds 3,5-dibromo-4-methoxyphenylacetonitrile, 3-bromo-4-methoxyphenylacetonitrile, 3-bromo-4-hydroxyphenylacetonitrile, 1-hydroxyuracil, 1-methoxyhemibastadin 2, purpuramine H and a steroid 5α,8α-epidioxycholest-6-en-3β-ol from the sponge Psammaplysilla purpurea. Compounds 1 and 2 were characterized by interpretation of their spectral data. The antibacterial activity of these compounds is summarized.抄録全体を表示PDF形式でダウンロード (58K) -
Tokujiro Kitagawa, Mizuki Nakamura, Katunori Masai原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 994-998
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーA convenient synthesis of 2- and 3-(chloroacetylamino)-3-(2-furyl)propanoic acids (6a, 7a) and their fluoro analogs were developed. Both 6a and 7a showed 51—55% root growth-inhibitory activity towards rape seedlings at the concentration of 1.0×10−4 M.抄録全体を表示PDF形式でダウンロード (75K) -
Sang Hee Shim, Ju Sun Kim, Sam Sik Kang原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 999-1002
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーFour new and five known norditerpenoid alkaloids were isolated from the processed tubers of Aconitum carmichaeli. The new alkaloids are 14-O-cinnamoylneoline (3), 14-O-anisoylneoline (4) 14-O-veratroylneoline (5), and lipo-14-O-anisoylbikhaconine (8). The known alkaloids are neoline (1), 14-O-acetylneoline (2), foresaconitine (6), crassicauline A (7), and lipohypaconitine (9). Alkaloids 2, 6, and 7 were isolated from this plant for the first time. The structures of the new alkaloids were established by spectroscopic and chemical methods.抄録全体を表示PDF形式でダウンロード (72K) -
Yasunori Yaoita, Hitomi Ono, Masao Kikuchi原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 1003-1005
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーRussulanorol (1), a new norsesquiterpenoid with a novel carbon skeleton, was isolated from the fruiting bodies of Russula delica FR. (Russulaceae) together with three known sesquiterpenoids. The structure of 1 was elucidated on the basis of spectral data and chemical transformation. Compound 1 is an equilibrium mixture of two stereoisomers (1a, b) on the C-11 acetal carbon.抄録全体を表示PDF形式でダウンロード (64K) -
Yoshitane Kojima, Yutaka Yoshikawa, Eriko Ueda, Rie Ueda, Shuhei Yamam ...原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 1006-1008
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーIn vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(−)-quinic acid (qui), were found in rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. Based on the results, the blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus was observed by daily i.p. injections of a monomeric zinc(II) complex, Zn(qui)2, for 13 d.抄録全体を表示PDF形式でダウンロード (63K) -
Weihan Zhang, Wing Keung Liu, Chun-Tao Che原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 1009-1011
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーPolyhydroxylated steroids and other metabolites were isolated from the soft coral Nephthea chabroli collected in South China Sea. The structures of two new compounds were determined to be 24-methylcholesta-9(11), 24(28)-diene-3β,12α,19-triol and 4α-methyl-3β,14β-dihydroxy-5α-ergost-24(28)-en-23-one on the basis of spectroscopic analysis. Cytotoxic activities of the polyhydroxylated sterols were evaluated on prostate carcinoma LNCaP cell line.抄録全体を表示PDF形式でダウンロード (52K) -
Hye Sook Kang, Hae Young Chung, Jee Hyung Jung, Byeng Wha Son, Jae Sue ...原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 1012-1014
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーA new phlorotannin, named eckstolonol (1), was isolated from the EtOAc soluble fraction of the methanolic extract of the brown alga, Ecklonia stolonifera OKAMURA, along with three known phlorotannins, eckol (2), phlorofucofuroeckol A (3), and dieckol (4). The structure of eckstolonol was identified as 5,8,13,14-tetraoxa-pentaphene-1,3,6,9,11-pentaol on the basis of spectroscopic evidence. The new compound was found to be a radical scavenger on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.抄録全体を表示PDF形式でダウンロード (58K) -
Yasushi Arakawa, Masafumi Ohnishi, Norikazu Yoshimura, Shigeyuki Yoshi ...原稿種別: Note
専門分野: [not specified]
2003 年 51 巻 8 号 p. 1015-1020
発行日: 2003年
公開日: 2003/08/01
ジャーナル フリーSynthesis of (1R,2S,5S,6R,8S)-3-azabicyclo[3.3.0]octane-2,6,8-tricarboxylic acid (2) from trans-4-hydroxy-L-proline (5) was attempted. A Diels–Alder reaction of 3,4-dehydroproline derivative 9 and cyclopentadiene afforded a single stereoisomer 11. The Diels–Alder adduct was smoothly converted to the hydrochloride of 2 (24) via RuO4 oxidation. Although some racemization of the material or product was observed during the synthetic processes, the amino acid 24 proved to be optically pure.抄録全体を表示PDF形式でダウンロード (101K)
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