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松原 守, 野原 大輔, 栗本 英治, 黒田 良孝, 酒井 朝也
1993 年 41 巻 7 号 p.
1207-1210
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Several factors and/or procedures were examined quantitatively to improve the refolding yields of hen egg white lysozyme from its fully denatured and reduced state. Firstly, we found that refolding treatments were better conducted at lower lysozyme concentrations. The refolding yield decreased from 70% to less than 5% by increasing the lysozyme concentration from 1 to 36μM in the refolding solution, probably due to aggregation. Secondly, in order to reduce the aggregation and improve the efficiency of refolding, we applied the "loose folding" procedure which required the incubation in the presence of about 2M urea. The refolding of the lysozyme, studied at 17.4μM, increased the yield to 80% yield in the presence of 2M urea compared with a 30% yield in the absence of urea. Furthermore, we obtained a dramatic refolding yield of more than 95% in an experiment conducted at a concentration of 1.1μM lysozyme, in the presence of 2M urea. Finally, we examined the "delayed oxidation" procedure which meant that conformational folding preceded formation of disulfide bounds. The application of this procedure resulted in increases of 5-10% in the refolding yield. These procedures are expected to be useful in improving the refolding yield of precipitated proteins, for example, formed during recombinant DNA protein syntheses.
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三宅 宗晴, 桐沢 誠, 古賀 憲司
1993 年 41 巻 7 号 p.
1211-1213
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Novel cyclophanes (9a, b) having eight carboxyl groups on the aromatic rings were designed and synthesized. Macrocyclization of 7a and 7b with 6 was carried out under a high dilution condition to give the corresponding 8a and 8b in 23% and 28% yields, respectively.
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田中 隆, 立花 英樹, 野中 源一郎, 西岡 五夫, 徐 鳳麟, 神田 博史, 田中 治
1993 年 41 巻 7 号 p.
1214-1220
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Chemical examination of the leaves of Rubus lambertianus SERINGE (Rosaceae) has led to the isolation of four new ellagitannins, which were characterized on the basis of chemical and spectroscopic evidence to be dimers [lambertianins A (6) and B (7)], a trimer [lambertianin C (8)] and a tetramer [lambertianin D (10)], all having sanguisorbic acid ester group(s) as linking unit(s) between glucopyranose moieties. Furthermore, HPLC analyses of fifteen Rubus species collected in Japan and Taiwan revealed that the trimer (8) and the tetramer (10), together with sanguiin H-6 (1), occur widely in these species.
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栗原 拓史, 坂本 靖彦, 高井 雅人, 大内 かおり, 春沢 信哉, 米田 龍司
1993 年 41 巻 7 号 p.
1221-1225
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Oxidation of 2-ethylhexahydroazeto[1', 2' : 1, 2]pyrido[3, 4-b]indole-1-carboxylate 9 with m-chloroperbenzoic acid in methylene dichloride at -5°C gava the corresponding cis-N-oxide 10, which was spontaneously transformed in tetrahydrofuran to the 3, 6-epoxy-1, 2, 3, 4, 5, 6-hexahydroazocino[5, 4-b]indole 11 (75%) via the [1, 2]-Meisenheimer rearrangement, along with a formation of the isoxazolidinone 12 (6.4%) through Cope elimination. The structural assignment of azocinoindole 11 was accomplished, mainly based on the
1H-NMR spectrum and also by chemical transformation of 11 to the azocinoindole 14.
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太田 俊作, 川崎 郁勇, 福野 晃久, 山下 正行, 多田 俊治, 川端 哲郎
1993 年 41 巻 7 号 p.
1226-1231
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
N-Unsubstituted 3-acyl-1H-1, 2, 4-triazoles (3), and 5-acyl-1-alkyl-1H-1, 2, 4-triazoles (4) were synthesized by acylation of 5-lithiotriazoles with amides. The 3-position of 1-methyl-5-phenylthio-1H-1, 2, 4-triazole (11) was lithiated by lithium 2, 2, 6, 6-tetramethylpiperidide, and acylation of the produced carbanion with amides followed by desulfurization with Raney nickel give the 3-acyl derivatives (5). The structural isomers, 3-acyl-4-alkyl-4H-1, 2, 4-triazoles (6), were prepared by N-methylation of 3.
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田中 隆, 折居 由利子, 野中 源一郎, 西岡 五夫
1993 年 41 巻 7 号 p.
1232-1237
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
From the dried leaves of Syzygium aromaticum MERR. et PERRY (Myrtaceae), eleven new compounds, i.e., eugenol 4-O-β-D-(6'-O-galloyl)glucopyranoside (17), 2-methyl-5, 7-dihydroxychromone 8-C-β-D-glucopyranoside (18) and its 6'-O-gallate (19), 2, 4, 6-trihydroxyacetophenone 3-C-β-D-glucopyranoside (20) and its 2'-O- (21), 6'-O- (22), 2', 3'-di-O- (23), 2', 6'-di-O- (24), 2', 3', 6'-tri-O- (25), 2', 3', 4', 6'-tetra-O-gallate (26) and 2', 3'-di-O-galloyl-4', 6'-O-(S)-hexahydroxydiphenoyl ester (27) were isolated, together with sixteen known tannins and related compounds. The structures of these compounds were established on the basis of spectroscopic and chemical evidence.
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/ 門田 重利, 寺島 恵, 清水 岑夫, 難波 恒雄, Tsuneo NAMBA
1993 年 41 巻 7 号 p.
1238-1243
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Ethyl acetate- and n-butanol-soluble fractions of the leaves of Morus insignis showed a significant hypoglycemic activity on streptozotocin (STZ)-induced hyperglycemic rats. From these hypoglycemic activity-showing fractions, two new compounds, mulberrofuran U (2) and moracin M-3'-O-β-D-glucopyranoside (3) were isolated, along with six known compounds [β-sitosterol, β-sitosterol-3-O-β-glucopyranoside, ursolic acid, moracin M (1), kaempferol-3-O-β-glucopyranoside and quercetin-3-O-β-glucopyranoside] and the structures of the new compounds were determined by spectroscopic and chemical methods.
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赤路 健一, 中川 喜仁, 藤原 洋一, 藤野 賢二, 木曽 良明
1993 年 41 巻 7 号 p.
1244-1248
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
A newly isolated rat brain natriuretic peptide 45 (rBNP45) was synthesized using the 9-fluorenylmethyloxy-carbonyl (Fmoc)-based solid-phase method. Tetrafluoroboric acid (HBF
4) deprotection was successfully applied for this synthesis, while the conventional trifluoroacetic acid (TFA)-thioanisole method gave unsatisfactory results. The disulfide bond of rBNP45 was constructed by using the silyl chloride method within 10min, which was extremely advantageous to avoid the formation of Met(O)-rBNP45. The chick rectum relaxant activity of the synthetic rBNP45 was three times as potent as that of α-rat atrial natriuretic peptide (α-rANP).
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古川 宏, 井藤 千裕, 呉 天賞 /, Andrew T. MCPHAIL
1993 年 41 巻 7 号 p.
1249-1254
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
In previous studies on the chemical constituents of Murraya euchrestifolia HAYATA (Rutaceae) collected in Taiwan, we preliminarily reported the first isolation and structure of a binary carbazole alkaloid, murrafoline-A (1). Since then, the isolation and spectroscopic structural elucidation of three new binary carbazoles, murrafoline-B (2), -C (5), and -D (3), have been reported. This paper describes in detail the structural elucidation of these novel binary carbazole alkaloids and also introduces two additional ones, murrafoline-G (4) and -H (6). Treatment of a mixture of girinimbine (7) and murrayafoline-A (8), which are monomeric carbazoles and structural components of murrafolines, with Nafion 117, an acidic perfluorinated ion-exchange resin, was found to produce murrafoline-D (3), -G (4), and -H (6).
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南雲 清二, 梶 紀裕, 井上 隆夫, 永井 正博
1993 年 41 巻 7 号 p.
1255-1257
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Two diarylheptanoid glycosides, acerosides V (1) and XI (2), were isolated from the stem bark of Acer nikoense MAXIM. (Aceraceae). On hydrolysis, 1 and 2 yielded new diarylheptanoids, acerogenin D (6) and acerogenin E (7), respectively. Acerogenin D (6) was chemically correlated with acerogenin C (5), and acerogenin E, with alnusone (8). On the basis of the chemical and spectroscopic evidence, the chemical structures of 1 and 2 were established as the 2-O-β-D-glucopyranoside of acerogenin D and 3-O-β-D-glucopyranoside of acerogenin E, respectively. Aceroside XI is the first example of the biphenyl type of diarylheptanoid isolated from this plant. A. nikoense thus contains three types of diarylheptanoid, linear, cyclic biphenyl and cyclic diphenyl ether types.
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Jean-Francois LAGORCE, Francis COMBY, Annick ROUSSEAU, Jacques BUXERAU ...
1993 年 41 巻 7 号 p.
1258-1260
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
A series of compounds was synthesized by linking various derivatives of pyridine, pyrimidine or pyrazine to thiazole-2-thiol or to its partially hydrogenated derivative 2-thiazoline-2-thiol. The reactions of the compounds with molecular iodine and lactoperoxidase were examined in vitro. Their antithyroid activity was also examined in vivo in the rat. T
4 and TSH levels were determined, and the thyroid gland was examined histologically. 2-(3-Hydroxy-2-pyridyl)-2-thiothiazoline had the highest antithyroid activity of the compounds tested (K
c=14931·mol
-1, IC
500.65×10
-4M, activity of thryoid gland +++).
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木津 良一, 金田 学, 山内 泰子, 宮崎 元一
1993 年 41 巻 7 号 p.
1261-1265
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Auranofin [(2, 3, 4, 6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-S)(triethylphosphine)gold(I) : AF] is a unique orally active chrysotherapy agent. A HPLC method has been developed for determining AF in urine. The proposed method comprises initial chromatographic separation of AF followed by on-line decomposition by potassium iodide with a released mercapto group undergoing a color-developing reaction with 5, 5'-dithiobis(2-nitrobenzoic acid). An aliquot (100μl) of a urine sample was chromatographed on a YMC AM-302 octadecylsilica column (4.6mm i.d.×15cm, ambient) with a water-methanol (35 : 65) eluent delivered at a flow rate of 1ml/min. A reagent solution for a postcolumn reaction comprised of 50μM 5, 5'-dithiobis(2-nitrobenzoic acid), 0.3M potassium iodide and a 50mM phosphate buffer (pH 7.4), was delivered at a flow rate of 0.5ml/min. The postcolumn reactor consisted of a poly(tetrafluoroethylene) tube (0.5mm i.d.×5m) at 60°C. Detection wavelength was 412nm. The identity of the AF peak was confirmed by a 3-dimensional chromatogram as well as by atomic absorption spectrophotometric analysis of gold in the column effluent. Under the conditions described above, a linear relationship was obtained between peak height and AF concentration in the range 0.1 to 10μM, with a correlation coefficient of 0.999. The detection limit was 50nM (S/N=3 at 0.005 AUFS) and the reproducibility was within 4% for 5 determinations. The AF concentrations in the urine of a rabbit given AF intraperitoneally were determined.
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糸川 秀治, 近藤 和行, 一柳 幸生, 中村 厚, 森田 博史, 竹谷 孝一
1993 年 41 巻 7 号 p.
1266-1269
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Several aromatic ring substituent modified RA derivatives were prepared from RA-VII (1), RA-V (8) and RA-II (11), and evaluated for cytotoxicity against P388 leukemia and KB cells. In terms of IC
50 values, the C
ζ methoxyl group of Tyr-3 greatly influenced the activities, while the substituents at the C
ζ position of Tyr-6 were less important. One of the derivatives, Tyr-6-C
ζ-deoxyRA-V (9, P388, IC
50, 0.0025μg/ml) was nearly as active as RA-VII (1, 0.0013μg/ml), and also expressed promising anti-P388 in vivo activity (test/control=171%, at 25mg/kg).
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山本 篤, 宮瀬 敏男, 上野 明, 前田 利男
1993 年 41 巻 7 号 p.
1270-1274
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
From the whole plants of Clinopodium gracile five new saponins, called clinoposaponins I-V, were isolated together with two known and four artifact saponins, and their structures elucidated from spectroscopic data and chemical evidence, These saponins were composed of saikosaponin a and additional glucose moieties.
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藤井 まき子, 日置 美恵子, 西 めぐみ, 逸見 剛士, 中尾 明子, 塩澤 久美, 松本 光雄
1993 年 41 巻 7 号 p.
1275-1278
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
The solid dispersion (SD) preparation method of indomethacin (IM, mp 161°C) with phosphatidylcholine (PC) was investigated. The melting point of PC is high, above 200°C, making a melting method inapplicable. However, PC shows a phase transition at about 100°C when its acyl chains are stearic acid and it is an anhydride. In the case of mole fraction of IM in SD being 0.50, X-ray diffraction patterns suggest that IM is in an amorphous state after heating at 90°C for 1h, at 110°C for 10min or at 180°C for 6min. When the mole fraction of IM is as low as 0.25 or 0.33, IM is also present in an amorphous state after heating at 70°C for 2h and at 90°C for 10min. The obtained SD showed endothermic peaks from about 40°C to 70°C upon thermal analysis. It is possible to prepare SD above 70°C, but this requires a long heating time; therefore, heating at above the phase transition temperature is most suitable. The dissolution patterns of IM from SD compressed into tablet form were fitted to Higuchi's square root equation and the dissolution rate was found to be 1.5-fold that from a physical mixture of the same composition.
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中森 克, 中島 俊明, 小田原 美樹子, 小山 郁夫, 根本 正美, 吉田 継親, 大島 広行, 井上 圭三
1993 年 41 巻 7 号 p.
1279-1283
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
The effect of taurine, as an isotonic solute, and of benzalkonium chloride (BZC), as a positive membrane component, on the long-term stability of liposomal suspensions was investigated by measuring surface potential. The surface potential, which introduced electrostatic repulsion to liposomes against aggregation, increased dose-dependently with the addition of BZC, which gave a positive charge. However, a further addition of BZC caused unexpected aggregation during storage, so the optimum addition of BZC was defined. On the other hand, taurine, which forms a zwitter ion in an aqueous solution, did not reduce the surface potential, suggesting that taurine is of possible utility as an isotonic solute. As the result of stability testing, the liposomal system using taurine and BZC was stable against aggregation during 6 months at 40°C. We were successful in developing a stable, positively charged liposomal system during long-term storage, and our liposomal system is believed to be of wide utility as a drug carrier for therapeutic drugs applied topically to negatively charged mucosal tissues.We applied the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory to estimate the colloidal stability of liposomes. As a result of stability testing, positively charged liposomes had a good correlation betwee maximum total repulsive energy (V
T(max)/kT) between two liposome particles and colloidal stability, suggesting that the V
T(max)/kT value is useful for estimating stability and for designing liposomal preparations containing some ionic substances.
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福岡 英平, 牧田 みどり, 山村 重雄
1993 年 41 巻 7 号 p.
1284-1289
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Features of the preferred orientation plane of some organic crystals were studied from a quantum chemical point of view. The interaction energies in those crystal planes in which cleavage is possible were calculated by using the interaction energies between two molecules. The intermolecular interaction energies were calculated by the CNDO/2 (complete neglect of differential overlap) method. The preferred orientation planes, which have a tendency to orient themselves parallel to the upper surface of a tablet during compression, showed only small interaction energy. Thus, the preferred orientation of crystallites in a tablet was considered to occur by cleavage along that crystal plane which had small interaction energy during compression.
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小股 泰子, 金子 明子, 藤江 忠雄
1993 年 41 巻 7 号 p.
1290-1292
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
The interaction between thiamine tetrahydrofurfuryl disulfide (TTFD) and saturated fatty acid (FA) in 1, 2-dichloroethane at 25°C was studied by phase solubility analysis using FA with various carbon numbers (14, 16, and 18), stearyl alcohol, and stearic acid methyl ester. The solubility of TTFD increased with the addition of FA. The solubility of TTFD also increased with the addition of stearyl alcohol, while its solubility decreased when stearic acid methyl ester was added.It was found that the solubility of stearic acid also increased with the addition of TTFD, and that TTFD cannot form a crystalline complex with stearic acid.These results are compared with those obtained for thiamine disulfide (TDS) and cycotiamine. The mode of the solubilization of TDS by FA in 1, 2-dichloroethane, and its relation to the crystallization of the complex between TDS and FA was discussed.
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高良 真也, 鶴屋 伸一郎, 木村 宗文, 緒方 孝一郎, 富永 義則
1993 年 41 巻 7 号 p.
1293-1296
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Reaction of α-oxoketene dithioacetals with arylamines was accelerated with a catalytic amount of BF
3-OEt
2 to give the corresponding α-oxoketene S, N-acetals selectively in good yields.
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小山 淳子, 小倉 環, 田ヶ原 清, 宮下 正昭, 入江 寛
1993 年 41 巻 7 号 p.
1297-1298
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Thermolysis of cyclohexanone oxime O-crotyl and O-cinnamyl ether in the presence of BF
3-etherate regioselectively gave 4-methyl- and 4-phenyl-5, 6, 7, 8-tetrahydroquinoline, while the addition of organic bases such as triethylamine and pyridine inhibited the rearrangement. These findings suggested that the addition of the acid made [1, 2] shift the predominant one of the two possible transformations, [1, 2] and [2, 3] shift, of the O-allyl ethers.
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小田 和明, 町田 實
1993 年 41 巻 7 号 p.
1299-1301
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Irradiation of arenecarbothioamide iwth 5-membered heteroaromatics, including benzo-fused 5-membered ones, gave regioselectively the corresponding 3-aroyl derivatives.
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井藤 千裕, 小野 友久, 竹村 優子, 中田 裕美子, 天 裕美, 十一 元晴, 岡野 正義, 深宮 斉彦, 古川 宏
1993 年 41 巻 7 号 p.
1302-1304
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
The acetone extract of the root of Citrus hassaku Hort. ex TANAKA (Rutaceae) was subjected to silica gel column and preparative thin layer chromatographies to obtain a new binary coumarin (biscoumarin) named hassmarin (1). The structure, corresponding to a Diels-Alder type adduct of demethyl derivatives of phebalosin (6) and trans-dehydroosthol (8), was assigned on the basis of spectral analyses.
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吉崎 司郎, 玉田 重晴, 楊 永雄, 梅里 正七男
1993 年 41 巻 7 号 p.
1305-1306
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
A series of procaterol derivatives having a substituent at the 7-position of the carbostyril moiety was synthesized. Halogenation of procaterol and its homologues gave the 7-halogeno derivatives (3). Nitration of the procaterol analogues afforded the 7-nitro derivatives (4), and the catalytic reduction of 4 gave the 7-amino derivatives (5). These compounds showed weak β-adrenoceptor stimulant activities in anesthetized dog.
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森田 博史, 松本 浩二, 竹谷 孝一, 糸川 秀治
1993 年 41 巻 7 号 p.
1307-1308
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
A novel azafluoranthene alkaloid, norimeluteine, has been isolated as a cytotoxic substance from Cissampelos pareira (Menispermaceae), together with an alkaloid having the same skeleton, norruffscine. Carbon-13 nuclear magnetic resonance assignments for the azafluoranthene alkaloids were performed by a combination of two dimentional NMR techniques.
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奥山 恵美, 梅山 一大, 斎藤 由紀恵, 山崎 幹夫, 佐竹 元吉
1993 年 41 巻 7 号 p.
1309-1311
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
"Paico, " Chenopodium ambrosioides L., is a traditional Peruvian medicine which is considered to be nervine, antirheumatic, anthelmintic, etc. An attempt was made to isolate the component having sedative and/or analgesic properties from "Paico" and "Aritasou" (the Japanese name for C. ambrosioides). Ascaridole was identified as the active principle in both materials.
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松枝 礼, 小池 勝夫, 高柳 一成
1993 年 41 巻 7 号 p.
1312-1314
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Dynorphin A derivatives containing S-(3-nitro-2-pyridinesulfenyl)-cysteine(Cys(Npys)) were designed and synthesized for affinity labeling of K opioid receptors. Derivatives with Cys(Npys) rsidue at the 8 position were highly potent and specific to K receptors and bound to receptors through disulfide bond formation.
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中村 恵宣, 秋山 泰身, 別所 清, 米田 文郎
1993 年 41 巻 7 号 p.
1315-1317
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Using CPG support linked with 5-deazaflavin, the 5-deazaflavin modified oligodeoxynucleotides at 3'-end(ODN-dFl) were synthesized. The thermal stability of the duplex of ODN-dFl with its complement was higher than that of oligonucleotide linked to 5-deazaflavin at 5'-end internucleotide linkage.
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川原 信夫, 関田 節子, 佐竹 元吉
1993 年 41 巻 7 号 p.
1318-1320
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
The structure and stereochemistry of a novel dimeric steroid, calvasterone (1), isolated from the fruiting body of Calvatia cyathiformis, has been established by spectroscopic data and chemical evidence.
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小林 典裕, 北堀 淳一, 真野 英俊, 島田 和武
1993 年 41 巻 7 号 p.
1321-1323
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
The production of highly specific antibodies to 1α, 25-dihydroxyvitamin D
3 1a utilizing a novel haptenic derivative 2, which was synthesized from 11
α, 25-dihydroxycholesterol via 21 steps, has been reported. The properties of the obtained antibodies are also described.
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小林 資正, 近藤 一成, 北川 勲
1993 年 41 巻 7 号 p.
1324-1326
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Antifungal peroxyketal acids and their methyl esters, the peroxyplakoric acids A
1 methyl ester (1), A
2 methyl ester (2), A
3 methyl ester (3), B
1 methyl ester (4), and B
3 methyl ester (5), were separated from an Okinawan marine sponge of Plakortis sp. The absolute stereostructures 1∼5 have been elucidated on the basis of chemical and physicochemical evidence.
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由利 正利, 徳元 真理絵, 原 典行, 藤本 善徳, 小林 典子, 森崎 益雄
1993 年 41 巻 7 号 p.
1327-1329
発行日: 1993/07/15
公開日: 2008/03/31
ジャーナル
フリー
Incubation of [27-
13C]-3α, 7α, 12α-trihydroxycoprost-24-en-26-oic acid with rat liver homogenate followed by
13C-NMR analysis of the incubation product has resulted in the identification of[26-
13C]-27-nor-3α, 7α, 12α-trihydroxycoprostan-24-one, supporting the idea that the substrate has been metabolized into 3α, 7α, 12α-trihydroxy-24-oxocoprostan-26-oic acid CoA derivative.
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