巻号一覧
52 巻, 10 号
選択された号の論文の28件中1～28を表示しています
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Regular Articles
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Yoshito Ohnishi, Takumi Okamoto, Satoru Watano2004 年 52 巻 10 号 p. 1155-1161
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーThe purpose of this study is to propose the application of a compression test to the determination of an optimal formulation for extrusion granulation. The electric current during extrusion was measured and the characteristics of the wet kneaded mass in the compression test were analyzed under various operating conditions, with different types of extruders and several formulations of kneaded mass. It was found that addition of a binder (HPC-L) to pharmaceutical powders lowered the load of a high-compressing type extruder, since the binder reduced the friction among the wet mass during extrusion. Also, the support stress was found to be proportional to the compression pressure without a binder, although an inflection point appeared on the support stress curve when a binder was present. This inflection point suggested large water retention of the wet kneaded mass, at which the medium of pressure was changed from a discontinuous solid powder to a continuous liquid, and large water retention contributed to the low friction of the wet mass. The friction of the wet kneaded mass and the aptitude of the formulation for extrusion were understood by using the compression test. The compression test is a very useful procedure at the first stage of a formulation study.抄録全体を表示PDF形式でダウンロード (1488K) -
Hua-Lin Liao, Ming-Kuan Hu2004 年 52 巻 10 号 p. 1162-1165
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーThe aim of this study was to develop potential anticancer agents based on a naturally occurring baicalein, a flavonoid from Scatellariae radix. Cinnamic acid derivatives were converted to corresponding chlorides and then condensed with 3,4,5-trimethoxyphenol in the presence of BF3·Et2O to give chalcones. Intramolecular cyclization of these intermediates by the actions of DMSO/I2 afforded the desired trimethylbaicalein derivatives. Cell viability after treatment with the tested compound for 2 d was determined by a colorimetric MTT assay. The results indicated that most of the derivatives showed improved inhibition of proliferation of Hep G2 cells. Compound 9 was the most potent, in which the cell viability was reduced to <2% at the 25 μM level. In the case of Hep 3B cells, 8a, 8b and 8f showed moderate inhibition of their proliferation and 25 μM was required to reduce the viability to ca. 30%. On the other hand, prostate DU145 cells were more resistant. Most of the derivatives caused a 60% inhibition of DU145 cells only at a concentration of 100 μM or above.抄録全体を表示PDF形式でダウンロード (366K) -
Mehdi Ansari, Maryam Kazemipour, Freshteh Khosravi, Mehdi Baradaran2004 年 52 巻 10 号 p. 1166-1170
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーLosartan, a highly effective blood pressure-lowering agent, has been widely used for the treatment of hypertension. A fast and reliable method for the determination of losartan was highly desirable to support formulation screening and quality control. A first-derivative UV spectroscopic method and HPLC were developed for the determination of losartan in the tablet dosage form. The first-derivative spectrum recorded between 220 and 320 nm and a zero-crossing technique for first-derivative measurement at 232.5 nm were selected. The selectivity and sensitivity of the method was in desirable range. In comparison with the direct UV method, first-derivative UV spectroscopy has a definite trough without any interference from UV absorbing-excipients. This method is also fast and economical in comparison with the more time-consuming HPLC method regularly used for formulation screening and quality control and can be used routinely by any laboratory possessing a spectrophotometer with a derivative accessory. The linear concentration ranges were 2—50 μg ml−1, (D1=−0.0159C−0.0056, r=0.9994, n=6). Between-days CV of ≤2.9%, within-day CV of ≤2.1%, and analytical recovery close to 98.1% show the suitability of the method for determination in quality control.抄録全体を表示PDF形式でダウンロード (189K) -
Giancarlo Cravotto, Gianni Balliano, Silvia Tagliapietra, Simonetta Ol ...2004 年 52 巻 10 号 p. 1171-1174
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーSqualene-hopene cyclase (SHC) is a useful model enzyme for predicting molecular interactions with oxidosqualene cyclase (OSC). Structure–activity relationships were investigated for numerous coumarin-derived inhibitors of SHC, and structural simplifications are suggested. Both umbelliferone and 2,4-dihydroxyacetophenone provide convenient starting nuclei for the design of SHC inhibitors. Derivatives bearing an ω-epoxyfarnesyl moiety or just a plain alkyl chain showed an inhibitory effect on a recombinant SHC from Alicyclobacillus acidocaldarius expressed in Escherichia coli.抄録全体を表示PDF形式でダウンロード (129K) -
Nguyen Manh Cuong, Tran Quang Hung, Tran Van Sung, Walter Chacles Tayl ...2004 年 52 巻 10 号 p. 1175-1178
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーA new dimeric pyranocarbazole alkaloid, bisisomahanine (1), was isolated from the roots of Glycosmis stenocarpa (DRAKE) TAN., along with two known monomeric carbazole alkaloids, murrayafoline-A (2) and murrayanine (3). The planar structure of bisisomahanine was determined to be 9,9″-dihydroxy-3,3″,8,8″-tetramethyl-3,3″-bis-(4-methyl-3-pentenyl)-3,3″,11,11″-tetrahydro-10,10″-(bipyrano[3,2-a]carbazole) from the combination of spectroscopic and chemical evidence. Bisisomahanine is the first dimeric prenylated pyranocarbazole alkaloid with a 1,1′ type of linkage; the NMR and CD spectroscopic data indicated it to be a mixture of diastereomers having a dominant configuration at the axis of chirality. 1H- and 13C-NMR assignments of murrayafoline-A were made on the basis of 2D-experiments.抄録全体を表示PDF形式でダウンロード (121K) -
Ali Akbar Saboury, Soghra Bagheri, Ghasem Ataie, Masoud Amanlou, Ali A ...2004 年 52 巻 10 号 p. 1179-1182
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーThermodynamic studies were carried out to evaluate the binding of theophylline on adenosine deaminase (ADA) in 50 mM sodium phosphate buffer pH 7.5, at 300 K, using isothermal titration calorimetry (ITC). A simple method for determination of binding isotherm in the drug–ADA interaction was applied using ITC data. ADA has two binding sites for theophylline, which show positive cooperativity in its sites. The intrinsic association equilibrium constants are 6 and 52 mM−1 in the first and second binding sites, respectively. Hence, occupation of the first site has produced an appreciable enhancement by 8.7 of the binding affinity of the second site. The molar enthalpies of binding are −12.2 and −14.9 kJ/mol in the first and second binding sites, respectively.抄録全体を表示PDF形式でダウンロード (104K) -
Yoshifumi Murata, Sayuri Kudo, Kyouko Kofuji, Etsuko Miyamoto, Susumu ...2004 年 52 巻 10 号 p. 1183-1185
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーThe orotic acid (OT) salt of chitosan (CS), CS-OT, and that of a CS derivative, CP, were prepared, and the adsorption of primary or secondary bile acid was investigated. Calcium-induced alginate gel beads (Alg-Ca) containing CS-OT were also prepared and autoclaved, and the possibility of these beads to act as a vehicle for oral administration to prevent hyperlipidemia was investigated. When taurocholate (TCA) and glycocholate (GCA) were present together in the medium, CS-OT adsorbed identical amounts of both bile acids. This trend was seen in all CPs, although the capacity to adsorb bile acid was affected by the number and/or structure of the amino groups in the CP. On the other hand, taurodeoxycholate, a secondary bile acid was preferentially adsorbed over TCA and GCA. Alg-Ca containing CS-OT took up bile acids in a similar manner as CS-OT irrespective of the water content of the gel matrix. As all elements can be taken as a food, Alg-Ca containing CS-OT could serve as a useful dietary agent for the prevention of hyperlipidemia, which is a lifestyle-related disease.抄録全体を表示PDF形式でダウンロード (123K) -
Yasuko In, Koji Tomoo, Toshimasa Ishida, Yasuhiko Sakamoto2004 年 52 巻 10 号 p. 1186-1189
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーThe (+)-enantiomer of modafinil [(RS)-2-(diphenylmethylsulfinyl)acetamide], a novel wake-promoting agent, was clarified to be S-configuration by X-ray crystal structure analysis. The crystal consists of two crystallographically independent conformers that are different at the torsion angles around the sulfinylacetamide moiety, and this results from the molecular packing requirement to form a two-dimensional hydrogen-bonding network via neighboring amide groups in the crystal. The crystal structure is characterized by the formation of alternative hydrophobic and hydrophilic layers, which are formed among the symmetry-translated assemblies of diphenylmethyl and sulfinylacetamide moieties, respectively. The spatial orientation between the diphenyl and amide groups is believed to be important for the activity of modafinil.抄録全体を表示PDF形式でダウンロード (1340K) -
Sheng-Jun Dai, Yan Wu, Ying-Hong Wang, Wen-Yi He, Ruo-Yun Chen, De-Qua ...2004 年 52 巻 10 号 p. 1190-1193
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーFractionation of the ethanolic extract of the stem bark of Morus macroura resulted in the isolation of four new Diels-Alder type adducts, named guangsangons K—N (1, 2, 5, 6), together with two known compounds, mulberrofuran G (3) and K (4). Their structures were determined on the basis of spectroscopic analyses and chemical methods. Furthermore, by means of 1H-NMR variable temperature experiments and the Cotton curves in the circular dichroism (CD) spectra, the stereochemistry of four new compounds was elucidated. The isolated new compounds showed good activity on anti-oxidant in vitro, with the inhibitory rates of MDA being from 91.8 to 100.0% at concentrations of 10−5 mol/l.抄録全体を表示PDF形式でダウンロード (115K) -
Toshio Morikawa, Bohang Sun, Hisashi Matsuda, Li Jun Wu, Shoichi Harim ...2004 年 52 巻 10 号 p. 1194-1199
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーA new β-carboline-type alkaloidal glycoside, glucodichotomine B, four new neolignan glycosides, dichotomosides A, B, C, and D, and a new phenylpropanoid glycoside, dichotomoside E, were isolated from a Chinese natural medicine, the roots of Stellaria dichotoma L. var. lanceolata. The structures of the new glycosides were determined on the basis of chemical and physicochemical evidence. Among them, dichotomoside D inhibited the release of β-hexosaminidase (IC50=64 μM) as well as tumor necrosis factor-α and interleukin-4 (IC50=16, 34 μM) in RBL-2H3 cells. These findings suggest that dichotomoside D is more effective against the late-phase reactions in type I allergy than in the immediate phase.抄録全体を表示PDF形式でダウンロード (177K) -
Hisashi Matsuda, Toshio Morikawa, Shin Ando, Hideo Oominami, Toshiyuki ...2004 年 52 巻 10 号 p. 1200-1203
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーTwo new polypodane-type triterpenes, myrrhanol A and myrrhanone A, were isolated from the 50% aqueous methanolic extract of guggul-gum resin [the resin of Balsamodendron (=Commiphora) mukul HOOK.]. The structures of the new constituents, including their absolute configurations, were determined on the basis of chemical and physicochemical evidence.抄録全体を表示PDF形式でダウンロード (141K) -
Tsukasa Ishihara, Hirotoshi Kakuta, Hiroshi Moritani, Tohru Ugawa, Isa ...2004 年 52 巻 10 号 p. 1204-1209
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーSqualene synthase inhibitors have the potential to be superior hypocholesterolemic agents. A series of quinuclidine derivatives incorporating phenothiazine systems was synthesized in order to investigate the effects of their structure on the inhibition of hamster liver microsomal enzyme. (±)-3-(10-Methyl-10H-phenothiazin-3-ylmethoxy)quinuclidine hydrochloride (19) was the most potent inhibitor in this series with an IC50 value of 0.12 μM. Oral dosing of compound 19 to hamsters demonstrated effective reduction of both plasma total cholesterol levels and plasma triglyceride levels. Compound 19 showed a reduced tendency to elevate plasma transaminase levels, an indicator of hepatotoxicity. Enantiomerically pure (−)-19, YM-53546, was found to be more potent than the corresponding (+)-enantiomer.抄録全体を表示PDF形式でダウンロード (235K) -
Masafumi Kikuchi, Masao Kikuchi2004 年 52 巻 10 号 p. 1210-1214
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーEight new secoiridoid diglycosides, 6′-O-α-L-arabinopyranosylswertiamarin (1), 3′-O-β-D-glucopyranosylswertiamarin (2), 4′-O-β-D-glucopyranosylswertiamarin (3), 3′-O-β-D-galactopyranosylswertiamarin (4), 6′-O-α-D-galactopyranosylswertiamarin (5), 6′-O-α-D-mannopyranosylswertiamarin (6), 6′-O-β-D-fructofuranosylswertiamarin (7) and 5″-O-β-D-glucopyranosylamaroswerin (12), were isolated, together with five known compounds from the whole plants of Swertia japonica MAKINO. The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence. Compounds 6 and 7 are the first naturally occuring iridoid diglycosides having an α-D-mannopyranosyl unit and β-D-fructofuranosyl unit, respectively.抄録全体を表示PDF形式でダウンロード (105K) -
Tsunetake Motai, Susumu Kitanaka2004 年 52 巻 10 号 p. 1215-1218
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーFour new sesquiterpene coumarin derivatives, fukanemarin B (1), fukanefuromarin E (2), fukanefuromarin F (3) and fukanefuromarin G (5) were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated based on spectral evidence, especially heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The 80% aqueous methanol extract of the roots of Ferula fukanensis (FFE) and the sesquiterpene coumarin derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ).抄録全体を表示PDF形式でダウンロード (122K) -
Abolghasem Jouyban, Anahita Fathi-Azarbayjani, William Eugene Acree2004 年 52 巻 10 号 p. 1219-1222
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーApplicability of a solution model, i.e. Jouyban–Acree model (JAM), for calculating surface tension of binary and ternary solvents at various temperatures has been shown employing experimental surface tension data collected from the literature. The accuracy of the model was evaluated by calculating average percentage deviation (APD) between calculated and observed values. The obtained overall APD (±S.D.) for JAM using binary solvent data were 4.06 (±4.27) and 8.07 (±9.78)%, respectively for correlative and predictive analyses. The corresponding values for the best similar model from the literature were 8.86 (±6.40) and 37.10 (±27.65)% and the mean APD differences between JAM and previously published model were significant (p<0.003). The capability of JAM for correlating surface tension of ternary solvents at various temperatures was also shown and the overall APD was 1.39 (±0.37)%.抄録全体を表示PDF形式でダウンロード (154K) -
Yasunobu Watanabe, Takako Fuji, Kazuhito Hioki, Shohei Tani, Munetaka ...2004 年 52 巻 10 号 p. 1223-1226
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーIt has been indicated that hydrophilic solid powder to which aqueous solution of a novel dehydrocondensing reagent DMT-MM is adsorbed becomes a simple solid-phase dehydrocondensing reagent of low cost. Reaction in a liquid–liquid biphasic system on the surface of a solid phase with a large area was accelerated by suspending this powder in a dichloromethane solution of a carboxylic acid and an amine to be condensed. The reaction was rapid with a high yield despite the heterogeneity of the system. Like general solid-phase reagents, a hydrophobic carboxamide alone could be isolated at a relatively high purity only by filtration of the resulting suspension of reaction mixture.抄録全体を表示PDF形式でダウンロード (75K) -
Tian-Shung Wu, Chia-Chan Hwang, Ping-Chung Kuo, Tsung-Hsiao Kuo, Amoor ...2004 年 52 巻 10 号 p. 1227-1230
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーPhytochemical investigation on the ethanol extract from the stems of Spiraea formosana has resulted in the isolation of four new neolignans, named spiraformin-A, -B, -C and -D (1—4), together with thirty five known compounds. Their structures were established primarily on the basis of 1D and 2D NMR spectral and chemical transformation methods.抄録全体を表示PDF形式でダウンロード (91K) -
Hiromi Hamamoto, Yukiko Shiozaki, Kayoko Hata, Hirofumi Tohma, Yasuyuk ...2004 年 52 巻 10 号 p. 1231-1234
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーIntramolecular oxidative coupling reaction of N-protected benzyltetrahydroisoquinoline derivatives using hypervalent iodine(III) reagents was investigated. The use of remarkable combination of phenyliodine bis (trifluoroacetate) (PIFA) and heteropoly acid (HPA) in wet acetonitrile smoothly afforded morphinandienone alkaloids, while neospirinedienone alkaloids were obtained in high yield under anhydrous conditions.抄録全体を表示PDF形式でダウンロード (129K)
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Marc Sautour, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Hildebert ...2004 年 52 巻 10 号 p. 1235-1237
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーPhytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-β-D-glucopyranoside (1), and five known compounds, soyacerebroside I (2), adenosine (3), β-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR. Compounds 1—6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.抄録全体を表示PDF形式でダウンロード (72K) -
Fumiko Fujisaki, Nobuhiro Abe, Kunihiro Sumoto2004 年 52 巻 10 号 p. 1238-1241
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーA conventional new route to the novel oxazolidin-2-one derivatives (3a—f) having two substituents on N-3 and C-4 in the oxazolidin-2-one ring was established with racemic β-aminoalanine derivatives (1) as the key starting materials.抄録全体を表示PDF形式でダウンロード (118K) -
Tomonori Tanaka, Tsuyoshi Ikeda, Miho Kaku, Xing-Hua Zhu, Masafumi Oka ...2004 年 52 巻 10 号 p. 1242-1245
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーThe root of Strobilanthes cusia BREMEK. (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used to treat influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia, mumps, and severe acute respiratory syndrome (SARS). In this study, we found a new lignan glycoside (6) and two new phenylethanoid glycosides (7, 8) together with five known compounds as chemical constituents of Strobilanthes cusia root. Some samples were examined for anti-herpes simplex virus type-1 (HSV-1) activity. Among the tested samples, lupeol showed anti-HSV-1 activity (EC50: 11.7 μM) and showed 100% inhibition of virus plaque formation at 58.7 μM.抄録全体を表示PDF形式でダウンロード (93K) -
Feng Wei, Lin-Yun Ma, Wen-Tao Jin, Shuang-Cheng Ma, Guo-Zhu Han, Ikhla ...2004 年 52 巻 10 号 p. 1246-1248
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーPhytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1—5). The structure of the new compound was elucidated on the basis of spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[β-D-glucopyranosyl(1—2)][β-D-glucopyranosyl(1—4)]-β-D-glucopyranosiduronic acid (aesculiside A, 6). The antiinflammatory activities of the four main saponins (1—4) were compared with those of total saponin extracts, and single saponins showed more potent activity than total saponin extracts in mice.抄録全体を表示PDF形式でダウンロード (90K) -
Soodabeh Saeidnia, Ahmad Reza Gohari, Nahoko Uchiyama, Michiho Ito, Gi ...2004 年 52 巻 10 号 p. 1249-1250
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーFrom the whole plant of Dracocephalum kotschyi BOISS., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1—8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), β-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-β-D-glucopyranoside (9), and limonen-10-ol 10-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (10). Compounds 1 (3.1 μM), 2 (3.1 μM), 3 (3.1 μM), 5 (6.2 μM), 6 (6.2 μM), and 8 (6.2 μM) were effective against epimastigotes of Trypanosoma cruzi.抄録全体を表示PDF形式でダウンロード (66K) -
Xin-Pu Li, Jie Yu, Jin-Yin Luo, Hong-Sheng Li, Fu-Jie Han, Xing-Guo Ch ...2004 年 52 巻 10 号 p. 1251-1254
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーIn the present study, a reversed phase high performance liquid chromatographic (RP-HPLC) method was established for simultaneous determination of chlorogenic acid, caffeic acid, ferulic acid, protocatechuic acid and protocatechuic aldehyde in a Chinese herbal preparation (Fufang-Pugongying-Mixture). The separation was performed on a Hypersil ODS-2 column by isocratic elution with methanol and 0.2 M acetate buffer (pH 3.6) (15 : 85, v/v) as the mobile phase at the flow-rate of 1.0 ml/min with operating temperature of 30 °C, and detection wavelength of 300 nm. A good linear regression relationship between peak-areas and concentrations was obtained over the range of 2—200 μg/ml for the five marker compounds mentioned above. The spike recoveries were within 96.72—104.07%. The variation coefficient (CV) values of the precision were in the range of 0.89—4.50%. Moreover the developed method has reference value for quantitative analysis of Taraxacum, Lonicera and Angelica.抄録全体を表示PDF形式でダウンロード (87K) -
Norberto Peporine Lopes, Pierre Alexandre dos Santos, Massuo Jorge Kat ...2004 年 52 巻 10 号 p. 1255-1257
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーA phytochemical investigation in plantlets of the Brazilian medicinal tree Virola surinamensis resulted in the isolation and structural determination of four new compounds: 3-hydroxy-4-methyl-2-(11′-piperonyl-n-undecyl)-butenolide; 3-hydroxy-4-methyl-2-(7′-piperonyl-n-heptyl)-butanolide; 9′-(3,4-methylenedioxy-phenyl)-nonanoic acid and 13′-(3,4-methylene-dioxyphenyl)-tridecanoic acid. Thirteen compounds previously isolated from seeds and adult plants were also reported.抄録全体を表示PDF形式でダウンロード (64K) -
Mariko Kitajima, Ken-ichiro Hashimoto, Manuel Sandoval, Norio Aimi, Hi ...2004 年 52 巻 10 号 p. 1258-1261
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーA new oleanan-type triterpene (1) and three new cincholic acid glycosides (2—4) were isolated from Peruvian “Uña de Gato” (Cat's claw, plant of origin: Uncaria tomentosa), a traditional herbal medicine in Peru. Their structures were determined by spectroscopic analysis.抄録全体を表示PDF形式でダウンロード (80K) -
Hideyuki Ito, Yasuko Nishida, Mie Yamazaki, Keisuke Nakahara, Malgorza ...2004 年 52 巻 10 号 p. 1262-1264
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーWe established callus cultures of the monocotyledonous plants Kniphofia foliosa and K. tuckii (Asphodelaceae), which produce the anthraquinone derivatives chrysophanol and its glycosides. The minor product chrysophanol 8-O-β-gentiobioside was fully characterized by spectroscopic analysis and synthesis.抄録全体を表示PDF形式でダウンロード (74K) -
Akihiro Hosokawa, Megumi Sumino, Tomonori Nakamura, Shingo Yano, Toshi ...2004 年 52 巻 10 号 p. 1265-1267
発行日: 2004年
公開日: 2004/10/01
ジャーナル フリーSix lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.抄録全体を表示PDF形式でダウンロード (157K)
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