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森 幸雄, 豊吉 一美, 馬場 茂雄
1973 年 21 巻 12 号 p.
2577-2584
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
This paper is intended to report the retention of tritium during enzymatic hydroxylation at the 4'position of 3'-methyl-4-dimethylaminoazobenzene [4'-
3H, or 5'-
3H] (3'-Me-DAB) or during nonenzymatic substitutions at the 4 position of 3-methylacetanilide (4-
3H, or 5-
3H), and the effect of the repeated administration of carcinogenic 3'-Me-DAB upon the aryl hydroxylation activity against 3'-Me-DAB (5'-
3H) and retention of tritium in the hydroxylated product. The enzymically formed 3'-methyl-4'-hydroxy-4-dimethylaminoazobenzene from 3'-Me-DAB (4'-
3H) retained tritium 94% on an average. Accordingly, it may be proved that the NIH shift also occurs in the enzymatic hydroxylation of 3'-Me-DAB (4'-
3H). The chemically produced 4-hydroxy-, 4, 6-dibromo-, and 4-nitro-3-methylacetanilide from 3-methylacetanilide (4-
3H) retained tritium approximately 65% in each case. Since no significant effect of feeding 0.06% 3'-Me-DAB for 1-4 weeks on the aryl hydroxylation activity against 3'-Me-DAB (5'-
3H) and retention of tritium in the hydroxylated product from 3'-Me-DAB (4'-
3H) was observed, it may be suggested that the aryl hydroxylase activity of rat liver against 3'-Me-DAB dose not be qualitatively changed during the early stage of the carcinogenesis by 3'-Me-DAB.
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富沢 宏, 藤田 礼子
1973 年 21 巻 12 号 p.
2585-2589
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
The Friedel-Crafts reaction of 2-methyl-1 (2H)-isoqumolone (I) gave products identified as 4- and 7-acetylated compounds (III and IV), 4-, 5-, and 7-propionylated compounds (VII, VIII, and IX), and 5- and 7-butyrylated compounds (V and VI).
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富沢 宏, 高坂 和弘, 本郷 弘司, 藤田 礼子, 加藤 秀樹, 王 昭雄
1973 年 21 巻 12 号 p.
2590-2593
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Reaction of 1-methyl-2 (1H)-thiopyridone with formaldehyde and hydrochloric acid was carried out. The main product in this reaction was 3-hydroxymethyl-1-methyl-2 (1H)-thiopyridone (IV) in 22% yield. The structure of products in this reaction were confirmed by their nuclear magnetic resonance spectral comparison.
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古川 潮, 吉田 孝利, 後藤 元雄, 林 清五郎
1973 年 21 巻 12 号 p.
2594-2601
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
The reaction of arylbiguanides and N-amidino-O-alkylisoureas with diketene was found to proceed through the acylated intermediates to give pyrimidines and s-triazines. The reaction of arylbiguanides with ethyl acetoacetate was also attempted and the proportion of pyrimidines and s-triazines obtained was found to be almost equall to that in the case of the reaction with diketene. Therefore, this reaction was also elucidated to proceed via the acylated intermediates.
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富沢 宏, 鈴木 敏之, 沢田 一, 本郷 弘司, 藤田 礼子, 加藤 秀樹, 王 昭雄
1973 年 21 巻 12 号 p.
2602-2606
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Reaction of 1-methyl-2 (1H)-quinolone with phosphoryl chloride and dimethylaniline was successfully carried out. The two products, 2-[4'-(dimethylamino) phenyl] quinolinium chloride (V) and 2-[4'-(dimethylamino) phenyl] quinoline (VI), were obtained in good yield, 76.2% for V and 2.6% for VI, which can be change the ratio between those two products of the reaction condition changed. The structure of products were confirmed by the corresponding Grignard reactions. The same reaction of 1-methyl-2 (1H)-thioquinolone was attempted with low yield and only one product (VI).
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富沢 宏, 王 昭雄
1973 年 21 巻 12 号 p.
2607-2612
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Reactivity of 1-methyl-2 (1H)-thiopyridone (I), 1-methyl-2 (1H)-thioquinolone (III), and 2-methyl-1 (2H)-thioisoquinolone (V) was compared with that of the corresponding oxygen compounds, 1-methyl-2 (1H)-pyridone (II), 1-methyl-2 (1H)-quinolone (IV), and 2-methyl-1 (2H)-isoquinolone (VI). In deuteration, I was less reactive than II, III entirely failed to react, and V reacted under a stronger reaction condition than VI. Bromination of I and V was carried out but they did not produce the expected products, although II and VI reacted easily. Grignard reaction as an example of the nucleophilic substitution reactions on III, which was most inactive to the electrophilic substitution reactions, revealed that III is more inactive than IV to this reaction and the yield was not good even under a more drastic condition.
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川西 正祐, 本郷 直子, 横山 陽, 田中 久
1973 年 21 巻 12 号 p.
2613-2616
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Palladium monothioacetylacetonate (Pd (SAA)
2) was found to be converted into palladium dithioacetylacetonate (Pd (SSAA)
2) in the presence of sodium sulfide. It was indicated that this reaction follows first order kinetics with respect to the concentrations of Pd (SAA)
2 and sodium sulfide, respectively and on the whole, second order kinetics. A new spectrophotometric method of determination of sulfide ion, which is applicable in the range from 8 μg to 240 μg of sulfide ion, was devised by the measurement of the absorbance of Pd (SSAA)
2 formed (510mμ).
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川西 正祐, 横山 陽, 田中 久
1973 年 21 巻 12 号 p.
2617-2621
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Mono-, di and tribrominated chelates were prepared by direct bromination of cobalt (III) monothioacetylacetonate (I). From Infrared and/or nuclear magnetic resonance spectra, it was assumed that I exists as cis (facial) isomer and in brominated chelates, each chelate ring is independent fundamentally. Linear relationship was observed between chemical shift of methine proton and dielectric function with respect to various solvents in I. In some solvents, such as benzene and pyridine, particular interactions are assumed for the explanation of the nuclear magnetic resonance spectra of I and the brominated chelates.
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片山 誠二, 赤堀 幸男, 森 啓
1973 年 21 巻 12 号 p.
2622-2626
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Analysis of nuclear magnetic resonance spectra of 8-hydroxyquinoline precisely have been carried out in various solvents, and the values of chemical shifts and coupling constants of the ring protons are extraporated in infinite dilution. These extraporated values indicate the characteristic and functional natures of solvents interacting with the solute molecule. The concentration and the solvent dependences are discussed in detail.
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鈴木 謙次, 安孫子 敬, 遠藤 信義, 佐々木 有亮, 有末 二郎
1973 年 21 巻 12 号 p.
2627-2633
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Four peptides, H-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH, H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH, H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH and H-Arg-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH were synthesized by the classical method and tested for the induction of experimental allergic encephalomyelitis in guinea pigs. Consequently, it was found that the length limit of the peptide chain for the induction of the disease was the nonapeptide, H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH.
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鈴木 謙次, 佐々木 有亮
1973 年 21 巻 12 号 p.
2634-2638
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Solid phase synthesis of H-Arg-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH was accomplished by two different approaches, stepwise chain elongation and fragment condensation. Two fragments, Boc-Ala-Glu (OBzl)-Gly-OH (II) and Boc-Phe-Ser-Trp-Gly-OH (IV), were used for fragment condensation. Overall yields of the decapeptide were 10% in stepwise chain elongation and 34% in fragment condensation respectively. A failure pentapeptide, H-Phe-Ser-Trp-Gly-Arg-OH, was isolated in the two procedures.
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庄子 昇, 近藤 嘉和, 竹本 常松
1973 年 21 巻 12 号 p.
2639-2642
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Diketene reacted with barbituric acids in the presence of the basic catalyst and gave the acetoacetyl derivatives (IV-VI) in excellent yields. Condensation of the 5-acetoacetylbarbituric acids with hydrazine and phenylhydrazine gave the pyrazole (IXa, Xa) and phenylpyrazole derivatives (XIa, XIIa) in quantitative yields, respectively. Intramolecular cyclization of 1, 3-dimethyl-5-acetoacetylbarbituric acid in the acidic conditions afforded the γ-pyrone derivative (VIII).
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東野 武郎, 林 英作
1973 年 21 巻 12 号 p.
2643-2652
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
The reaction of pyrido [2, 3-d] pyrimidine (I) with several nucleophilic reagent was carried out. In the reaction of I with hydrazine reagent added across the 3, 4-positions in I to result in the formation of 3-hydroxy-4-hydrazino-3, 4-dihydropyrido [2, 3-d] pyrimidine (V). In the case of the reaction with acetic anhydride ring fission between the 2- and 3-positions took place and resulted in the formation of 2-aminonicotinonitrile (VI). The similar ring fission also occurred in the use merely alkali hydroxide for I at ordinary temperature to form 2-(formylamino) nicotinoaldehyde oxime (VII). In the case of the reactions with ethyl cyanoacetate, malononitrile and ethyl acetoacetate without base catalyst the transformation of I into 1, 8-naphthyridine derivatives proceeded to result in the formation of ethyl 2-amino-1, 8-naphthyridine-3-carboxylate (X), 2-amino-1, 8-naphthyridine-3-carbonitrile (XI) and ethyl 2-methyl-1, 8-naphthyridine-3-carboxylate (XII), respectively. In the case of the reaction with symmetric β-diketone without base catalyst 2-substituted-pyrido [2, 3-d] pyrimidine was formed. Thus the reactions with 2, 4-pentanedione and with 1, 3-diphenyl-1, 3-propanedione gave 1-(2-pyrido [2, 3-d] pyrimidinyl)-2-propanone (XX) and 2-(2-pyrido [2, 3-d] pyrimidinyl) acetophenone (XXI), respectively. But in the case of the reaction with asymmetric β-diketone such as 1-phenyl-1, 3-butanedione it proceeded in a defferent way from the reaction with symmetric β-diketone and resulted in the transformation of I into 2-phenyl-1, 8-naphthyridine (XXVIII). The possible reaction processes for the reactions described above were also proposed and discussed.
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川西 正祐, 横山 陽, 田中 久
1973 年 21 巻 12 号 p.
2653-2660
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
In platinum (II) dithioacetylacetonate which was obtained from monothioacetylacetone and platinum (II) ion in acidic medium by the replacement reaction of the ligand atom, considerable π-delocalization of the chelate ring is presumed by the spectroscopic data. Platinum (IV) monothioacetylacetonate which was obtained from monothioacetylacetone and platinum (II) ion in neutral medium did not produce dithio chelate with hydrogen sulfide unlike the case of palladium chelate. In the reaction of monothioacetylacetone with rhodium similar chelate formations were observed to the case of platinum chelate. In the reaction of monothioacetylacetone with mercury (II) ion, the product was a polymeric complex, which is considered to be produced from unstable complex through a intermolecular replacement of the ligand atom. From disulfide of monothiodibenzoylmethane, platinum, rhodium and mercury ions produced respective metal chelates or complexes. These features of the complex formations are attributed to bcharacter of these metals, namely particularly high affinity of these metals to sulfur.
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加藤 日出男, 越中 栄一, 荒田 義雄, 花岡 美代次
1973 年 21 巻 12 号 p.
2661-2666
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
A new synthesis of the spirodiamines (IIIa-c) from the methiodides (Ia-c) via the spiroaminolactams (VIIa-c) by Stevens rearrangement is described.
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友田 正司, 中塚 里美, 玉井 美恵子, 長田 みどり
1973 年 21 巻 12 号 p.
2667-2671
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
A mucous polysaccharide, named Bletilla-glucomannan, has been isolated from the tubers of Bletilla striata REICHENBACH fil. It was homogeneous on glass-fiber paper electrophoresis and by ultracentrifugal analysis. The component sugars of it were D-mannose and D-glucose, and the molar ratio of them was 3 : 1. The molecular weight was estimated at 182000 by the measurement of osmotic pressure. Periodate oxidation and partial acid hydrolysis of it suggested that the polysaccharide is mainly composed of β-1→4 linked aldohexopyranose residues and it contains six aldohexose units per one end group on the average.
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荒田 義雄, 小田 幸雄, 安田 信吾, 花岡 美代次
1973 年 21 巻 12 号 p.
2672-2678
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
1-Methyl- and 1-ethyl-cis-octahydroazecine (I and X) were synthesized stereoselectively. Transannular reaction of the trans-N-oxide (VII) leading to decahydro-1-methylazecin-6-one (XI) proceeded more smoothly than that of the cis-N-oxide (VI). However, transannular cyclization between the nitrogen and the double bond of N-acetyl-and N-ethoxycarbonyl-cis-octahydroazecine (VIII and XII) producing 1-azabicyclodecane (XVI) proceeded much more easily than that of the corresponding trans derivatives (IX and XIII).
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堀井 善一, 中下 善彦, 國沢 貴美子, 岩田 宙造
1973 年 21 巻 12 号 p.
2679-2683
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Irradiation of 2-bromo-N-ethyl-4'-hydroxybenzanilide (Ia) in aqueous sodium hydroxide gave 2'-ethylspiro [cyclohexa-2, 5-diene-1, 1'-isoindoline]-3', 4-dione (II), N-ethyl-4'-hydroxybiphenyl-2-carboxamide (III), and 4'-hydroxybenzanilide (IV). When the above photolysis was run in the presence of sodium borohydride, 2'-ethyl-4-hydroxyspiro-[cyclohexa-2, 5-diene-1, 1'-isoindolin]-3'-one (V) was obtained in good yield. This dienol (V) was oxidized with manganese dioxide to give the spiro-dienone (II). On the other hand, irradiation of 2-chloro-N-ethyl-4'-hydroxybenzanilide (Ib) in aqueous sodium hydroxide gave almost the starting material. However, when the photolysis of Ib was run in the presence of sodium borohydride or sodium sulfite, the biphenyl (III) was obtained in good yield. The reaction processes of these reactions were discussed.
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遠藤 徹, 田口 平八郎
1973 年 21 巻 12 号 p.
2684-2688
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Two new iridoid glycosides, geniposide and genipin-1-β-D-gentiobioside, were isolated from the fruits of Gardenia jasminoides ELLIS f. grandiflora (LOUR.) MAKINO and their structures were determined to be I and II, respectively.
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加藤 仁, 西尾 伸太郎, 粕谷 豊, 高木 敬次郎
1973 年 21 巻 12 号 p.
2689-2694
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
The effects of five diphenylalkanolamine derivatives, including YS 3635, YS 3636, YS 3632, YS 3623 and YS 3423, on the coronary and hindquarter vascular beds in anesthetized dogs were studied and compared with those of glyceryl trinitrate and papaverine. These five derivatives in doses of 62.5 to 1000μg i.a. reduced coronary and hindquarter vascular resistances, and the effects were in the following order : YS 3423>YS 3623> papaverine>YS 3632>YS 3635>YS 3636 in the coronary, and YS 3423> papaverine>YS 3623>YS 3635>YS 3632>YS 3636 in the hindquarter vascular beds. Three derivatives, YS 3423, YS 3623 and YS 3635 having a relatively potent vasodilating effect were further examined. These compounds, 1 mg/kg i.v., also showed an increase in coronary and hindquarter blood flows, concomitantly with a transient hypotension, sustained decrease in heart rate and increase in cardiac output. The vasodilating effect of the diphenylalkanolamine derivatives studied appears to show a direct and non-specific effects on the peripheral blood vessels as is the case of glyceryl trinitrate or papaverine.
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藤井 澄三, 吉藤 茂行, 道下 一彦, 三口 守公, 吉田 清史
1973 年 21 巻 12 号 p.
2695-2704
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
The mercuric acetate-EDTA oxidation of 1-(3, 4-dimethoxyphenyl)-2-piperidinoethanol (IV : R
1=H ; R
2=CH
3O) to form 1-[2-(3, 4-dimethoxyphenyl)-2-hydroxyethyl]-2-piperidone (XI : R
1=H ; R
2=CH
3O) was extended to include 3-alkylpiperidine derivatives (IV : R
1=CH
3, C
2H
5), which were synthesized from 3-alkylpyridines (II : R
1=CH
3, C
2H
5) by quaternization with phenacyl bromides followed by catalytic and NaBH
4 reductions. It was found that the 3-methyl and 3-ethyl groups of IV almost equally oriented the oxidation to both the 2- and 6-positions but with a slight advantage to the latter position. In contrast, the alkaline ferricyanide oxidation of quaternary salts V (R
1=CH
3, C
2H
5) at 32°produced 2-pyridones (IX) as the main product and 6-pyridones (XIII) as the minor product. It seemed that a higher 3-alkyl substituent caused the extent of 6-pyridone formation to increase slightly (Table I). The structures of the pyridones (IX and XIII) were assigned on the basis of their ultraviolet, infrared, and nuclear magnetic resonance spectra (Tables II and III), and the chemical correlations (IX→VI←VII and XIII→X←XI) shown in Chart 2 established the structures of the hydroxypiperidones (VII and XI) obtained by the mercuric acetate-EDTA oxidation method. In alternative synthesis of Xe, 1-benzyl-5-ethyl-2-piperidone (XV) was debenzylated with sodium and liquid ammonia to give XIV. Treatment of the potassium salt of XIV with phenethyl bromide furnished Xe.
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近藤 紀子, 庄司 順三, 田中 治
1973 年 21 巻 12 号 p.
2705-2711
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
The chemical structures of saponin-A (I) (=chikusetsusaponin V), C
48H
76O
19, [a]
20D+14.5° (MeOH) and saponin-D (V) (=ginsenoside Rb
1), C
54H
92O
23, [a]
20D+15.78° (MeOH), which were isolated from Panax pseudoginseng subsp. himalaicus var. angustifolius (Araliaceae), were established on the basis of physical data and chemical investigations.
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上野 明, 市川 雅博, 福島 清吾, 斎木 保久, 森永 邦夫
1973 年 21 巻 12 号 p.
2712-2714
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
A new isoflavanone derivative named lespedeol B was isolated from the bark of Lespedeza homoloba NAKAI. The structure was established as 2', 4', 5-trihydroxy-8-methyl-8-(4-methylpent-3-enyl) pyrano (3, 2-g) isoflavanone by spectral and chemical data, in which lespedeol B was formed by the dehydrocyclization of lespedeol A.
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上野 明, 市川 雅博, 福島 清吾, 斎木 保久, 野呂 忠敬, 森永 邦夫, 桑野 晴光
1973 年 21 巻 12 号 p.
2715-2721
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Two new coumaranochromane derivatives named lespein and lespedezin were isolated from the bark of Lespedeza homoloba NAKAI. On the base of the chemical and spectral data, their structures were established as (-) lespein : 6a, 10-diisopentenyl-3, 9-dihydroxy-(6aR, 11aR) pterocarpan and lespedezin : 10-geranyl-3, 9-dihydroxypterocarpan.
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高木 良成, 石井 伸彦, 井手 至, 赤星 三弥
1973 年 21 巻 12 号 p.
2722-2724
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Several aminoethyl and pyrrolidylmethyl thiosulfate and thiophosphate derivatives were synthesized and tested for the radioprotective effect in X-irradiated mice. Sodium hydrogen S-(L-2-pyrrolidylmethyl) phosphorothioate was most protective among ten compounds tested. It was effective to a same extent as cysteamine which is a typical radioprotector. N-Methylpyrrolidyl derivative of the compound was completely inactive. Furthermore, no radioprotection was observed in case of the corresponding thiosulfate.
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南原 利夫, 川原田 良彦, 浅間 三樹子, 秋山 節子, 野久保 宗孝, 本間 誠次郎
1973 年 21 巻 12 号 p.
2725-2732
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
In order to characterize the biliary metabolites the catechol estrogen 16, 17-ketols and their monomethyl ethers have been synthesized as reference compounds employing the method worked out by Gallagher and his co-workers. The preparation of 2-methoxy-16α-hydroxyestrone 3-glucuronide acetate-methyl ester (Vd) has also been described.
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京極 和旭, 畑山 勝男, 小松 曼耆
1973 年 21 巻 12 号 p.
2733-2738
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
From the Chinese crude drug, "Kushen"(Japanese name "Kujin") (the root of Sophora flavescens AIT.) five new flavonoids, kuraridinol (I), kurarinol (II), neokurarinol (III), nor-kurarinol (IV), isokurarinone (V) (each named by us) and formononetin were isolated, whose structures have been established by spectral and chemical data.
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日野 亨, 鈴木 利一, 武田 さちえ, 加納 信子, 石井 庸一, 佐々木 朗, 中川 昌子
1973 年 21 巻 12 号 p.
2739-2748
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
The reaction of 3-alkylindoles (1) with sulfur monochloride in ether gave the corresponding 2-diindolyl disulfides (2) as the main product, and mono and tri-sulfides (3) as minor products. The similar reaction of 3-arylindoles (6) gave the disulfides (7) in good yields. 2-Chloro derivatives (4 and 9) were obtained as the minor products in the reaction of 1e and 6d. The reactions of 1e, 6g and 6h with sulfur monochloride in ether were very slow, but proceeded rapidly in methylene chloride. The reduction of these diindolyl disulfides (11) with sodium borohydride in ethanol afforded the 2-indolinethiones (12) in good yields. These reactions are a general method for the preparation of 3-substituted 2-indolinethiones from 3-substituted indoles.
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林 益忠, 粟津 荘司, 花野 学, 野上 寿
1973 年 21 巻 12 号 p.
2749-2756
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
Elimination from plasma and distribution to brain and liver of eight barbituric acid derivatives in J.P. VIII were studied pharmacokinetically after intravenously administration to rat. Plasma concentration time courses of the barbituric acid derivatives were analyzed well with two compartment model. Distribution to brain of the lipid soluble barbituric acid derivatives was so rapid that brain was assigned to compartment I which includes plasma, while the distribution of the acids which have low lipid solubility was slow and the brain was found to be assigned to compartment II, especially for barbital, allobarbital and phenobarbital. On the other hand, liver was assigned to compartment I. As for pharmacokinetic constants, elimination rate constant was found to have a significant regression against lipid solubility (measured as a partition coefficient between CCl
4 and pH 7.4 phosphate buffer) except thiopental which belongs to the different series from the other seven barbituric acid derivatives in this paper. On the other hand, distribution rate constants, k
12 and k
21 were found to have no regression against lipid solubility. From these results, a clue was given to anticipate the plasma concentration and brain level time courses of barbituric acid derivatives from their lipid solubility.
抄録全体を表示
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松浦 信, 國井 敏信, 松浦 暘
1973 年 21 巻 12 号 p.
2757-2759
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
5, 3', 4'-Trihydroxy-6, 7-dimethoxyflavone and 5, 4'-dihydroxy-6, 7, 3'-trimethoxyflavone were synthesized and identified with cirsiliol and cirsilineol obtained from Cirsium lineare SCH. BIP.
抄録全体を表示
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王 昭雄
1973 年 21 巻 12 号 p.
2760-2763
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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松井 道夫, 絹山 優子, 箱崎 美砂子, 安倍 福雄, 川瀬 雅子, 岡田 正志
1973 年 21 巻 12 号 p.
2764-2768
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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李 和啓, 森田 明, 斎藤 洋, 高木 敬次郎
1973 年 21 巻 12 号 p.
2768-2770
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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富永 義則, 夏木 令子, 松田 芳郎, 小林 五郎
1973 年 21 巻 12 号 p.
2770-2775
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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渡瀬 幸宏, 寺尾 良保, 関屋 実
1973 年 21 巻 12 号 p.
2775-2778
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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西部 三省, 久田 末雄, 稲垣 勲
1973 年 21 巻 12 号 p.
2778-2779
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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正木 幸雄, 大塚 英夫, 中山 よ志江, 日置 雅治
1973 年 21 巻 12 号 p.
2780-2783
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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関 雅夫, 森崎 益雄, 池川 信夫 /, JULIETA RUBIOLIGHTBOURN
1973 年 21 巻 12 号 p.
2783-2785
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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日野 亨, 鈴木 利一, 中川 昌子
1973 年 21 巻 12 号 p.
2786-2789
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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廣瀬 良男, 黒岩 信, 山下 晴代, 田中 健夫, 恵 敏治
1973 年 21 巻 12 号 p.
2790-2793
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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南原 利夫, 池川 繁男, 細田 宏
1973 年 21 巻 12 号 p.
2794-2796
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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藤平 栄一, 大島 隆, 潮田 勇, 古橋 忠和, 高橋 紀光, 笹島 道忠, 田中 一郎
1973 年 21 巻 12 号 p.
2796-2798
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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荒木 健伍, 橘 真郎, 内山 幹男, 中嶋 輝躬, 安原 義
1973 年 21 巻 12 号 p.
2801-2804
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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中山 仁, 金岡 祐一
1973 年 21 巻 12 号 p.
2804-2805
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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林 紘司, 中村 博幸, 三橋 博
1973 年 21 巻 12 号 p.
2806-2807
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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杠 輝昭, 片山 幸一, 藤田 孟
1973 年 21 巻 12 号 p.
2807-2809
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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首藤 紘一, 岡本 敏彦
1973 年 21 巻 12 号 p.
2809-2811
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー
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南原 利夫, 野久保 宗孝
1973 年 21 巻 12 号 p.
2812-2813
発行日: 1973/12/25
公開日: 2008/03/31
ジャーナル
フリー