The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
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Volume 133, Issue 7
Displaying 1-5 of 5 articles from this issue
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Committee Report
Seminar for Medical Education
Case Reports
  • A Case of Cutaneous Melanocytoma Confirmed by TRIM11 Gene Rearrangement
    Aiko Nambu, Tomoe Nakagawa, Taisuke Matsuya, Mari Kishibe, Isao Tandai ...
    2023 Volume 133 Issue 7 Pages 1671-1678
    Published: June 20, 2023
    Released on J-STAGE: June 20, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.1671
    JOURNAL RESTRICTED ACCESS
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    A 56-year-old Japanese man presented with a six-month history of a nodule on the left middle finger. The nodule was a 1.2 cm in size, skin-colored, subcutaneous nodule. The excisional biopsy showed dermal proliferation of melanocyte marker-positive, spindle-shaped cells, which were negative for EWSR1-ATF1 fusion. Since there were no lesions other than the primary one, the patient was initially diagnosed with primary dermal melanoma. Thereafter, additional resection and sentinel lymph node biopsy were performed. TRIM11 staining and FISH subsequently, led to the final diagnosis of cutaneous melanocytoma with TRIM11 gene rearrangement. During eight months of follow-up after surgery, there was no local recurrence or distant metastasis. Cutaneous melanocytoma has been recently proposed as a melanocytic tumor with a good prognosis and is detected with CRTC1-TRIM11 fusion in cases analyzed by molecular biological methods. Long-term follow-up is required to determine the clinical course of this tumor.

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