We treated 34 atopic dermatitis patients with dupilumab, and evaluated its efficacy and side effects. The scores of IGA, EASI, BSA, POEM and DLQI improved in all the patients. Levels of LDH, IgE, and TARC also improved in almost all cases. As side effects, elevations of esosinophils were seen in 13 cases, allergic conjunctivitis / periocular itchness or redness in 15 cases, cough/asthma in 6 cases, herpes simplex in 4 cases, and Kaposi's varicelliform eruption, psoriasis-like eruption, and exfoliation of the skin in 1 case each. No severe reactions led to discontinuation of treatment. Dupilumab is well tolerated and effective.
Asteatosis, meaning dry skin, is found in senile xerosis caused by aging and in infants with immature skin function. It is also associated with diseases such as atopic dermatitis, ichthyosis, diabetes, and chronic kidney disease, and arises with treatment by some anticancer agents and radiation therapy. Asteatosis is often accompanied by itching and can progress into eczema due to scratching. Although it is necessary to treat asteatosis with a moisturizer, including prescription drugs and self-medication products, in accordance with the disease and skin condition, there are no clear treatment criteria. Therefore, publication of a guideline for asteatosis treatment is desired.