The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
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Volume 133, Issue 13
Displaying 1-9 of 9 articles from this issue
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Obituary
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Seminar for Medical Education
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Case Reports
  • Acquired Hemophilia A in a Patient with Pemphigus Vulgaris: A Case Report
    Saya Hisano, Emi Kaneda, Yoshimi Ando, Hirotsugu Shirabe
    2023 Volume 133 Issue 13 Pages 3075-3081
    Published: December 20, 2023
    Released on J-STAGE: December 22, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.3075
    JOURNAL RESTRICTED ACCESS
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    Acquired hemophilia A is a rare disorder in which factor VIII inhibition occurs, resulting in decreased factor VIII levels and sudden subcutaneous or intramuscular hemorrhage. Although the mechanism of inhibition development remains unclear, it is sometimes associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, suggesting autoimmune involvement. An 80-year-old woman was diagnosed with pemphigus vulgaris after developing oral erosions one and a half months before her initial visit. She was treated with prednisolone 25 mg/day; however, her condition did not improve and high-dose gamma globulin therapy was administered. Her symptoms improved, but, when the dose of prednisolone was reduced to 12.5 mg/day, an intramuscular hematoma was observed in her right upper limb, and she was diagnosed with acquired hemophilia A. This case demonstrates that acquired hemophilia A may also be associated with autoimmune bullous dermatosis. Dermatologists should consider this condition when bleeding symptoms such as purpura and swelling are observed, even if the patient has a good therapeutic response with regards to the bullous disease.

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  • A Preliminary Study to Define the Concept of Skin Frailty in the Elderly
    Makoto Kawashima, Tetsuro Nakamura, Masatoshi Abe, Kazuya Ooi, Shinji ...
    2023 Volume 133 Issue 13 Pages 3083-3087
    Published: December 20, 2023
    Released on J-STAGE: December 22, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.3083
    JOURNAL RESTRICTED ACCESS
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    The concept of frailty in the elderly is becoming widely recognized. Skin symptoms are not currently included in the criteria for frailty. However, some skin symptoms are frequently observed in the elderly. We considered the possibility of predicting frailty or its risk from skin symptoms by evaluating the presence and degree. We then created a questionnaire to evaluate skin conditions and conducted a preliminary study to confirm its validity. The skin condition of each patient was evaluated independently by dermatologists, internal physicians, and nurses. No major discrepancies were found among their reports, and the questionnaire form was regarded to be quite appropriate.

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