The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
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Volume 134, Issue 1
Displaying 1-7 of 7 articles from this issue
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Guidelines
Seminar for Medical Education
Original Articles
  • Intravenous Immunoglobulin Therapy for Patients with New-onset Pemphigus in Gunma University Hospital
    Yukie Endo, Mayu Nishio, Keiju Kosaka, Mizuho Nakajima, Jain Kim, Mai ...
    2024 Volume 134 Issue 1 Pages 83-90
    Published: January 20, 2024
    Released on J-STAGE: January 22, 2024
    DOIhttps://doi.org/10.14924/dermatol.134.83
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    We studied 45 hospitalized patients with new-onset pemphigus treated in Gunma University Hospital between January 2011 and December 2020. Among the 45 patients, 9 received intravenous immunoglobulin (IVIg) treatment. The following data were collected from medical charts and compared between patients with and without IVIg treatment: clinical manifestations, treatments, reasons for IVIg administration, therapeutic effects, clinical outcomes at 52 and 104 weeks, and adverse events. The IVIg group had significant decreases in anti-desmoglein antibody titer eight weeks after the start of treatment, but there were no statistically significant differences in outcome. This was a retrospective study with a small sample size. Further investigations regarding the early administration of IVIg are needed.

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Case Reports
  • A Case of Cutaneous Sarcoid-like Granuloma Induced by Nivolumab for Pharyngeal Cancer
    Aki Honda, Makoto Ishikawa, Toshiyuki Yamamoto
    2024 Volume 134 Issue 1 Pages 91-98
    Published: January 20, 2024
    Released on J-STAGE: January 22, 2024
    DOIhttps://doi.org/10.14924/dermatol.134.91
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    We here describe a rare case of sarcoid-like granuloma arising in a male patient with pharyngeal cancer during nivolumab therapy. Ten weeks after introduction of nivolumab, the patient developed pruritic erythematous plaques on his trunk; and histopathological examination revealed non-caseating epithelioid granulomas in the dermis. No other organs such as the lungs, eyes, and heart were involved, and serum levels of angiotensin converting enzymes were normal. The skin lesions were well controlled by use of topical corticosteroids without systemic corticosteroid treatment or nivolumab discontinuation. However, the patient later developed hypothyroidism and increased serum amylase levels suggestive of acute pancreatitis, so nivolumab was finally discontinued. Among cutaneous immune-related adverse events, sarcoid-like granuloma is rare. In the current report, we also review previous reports on cutaneous sarcoidosis/sarcoid-like granuloma and discuss the possible mechanism of the induction of sarcoid-like granuloma during immune checkpoint inhibitor therapy.

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