We gave ivermectin to 40 patients with scabies and examined the comparative effectiveness and safety between the groups treated after a meal and between meals. The total number of treated cases were 48. This included 8 cases who were treated twice or three times because of recurrences. Ivermectin was given based on the guideline for the Diagnosis and Treatment of Scabies. Combination therapies using 25% benzyl benzoate lotion on the outside of the entire body and freeze medical treatment to a prurigo node were chosen according to the properties and parasitism patterns of each scabies case. The results revealed improved effectiveness rates and decreased relapse rates in the group treated after a meal. Although there were two cases with abnormal blood test data, no clinical side effects were observed.
A randomized controlled trial (RCT) was conducted to assess the usefulness of medical moisturizers (heparinoid preparation, urea preparation and petrolatum) for improving the dry skin of patients with atopic dermatitis (AD), using the following parameters : water content of stratum corneum, transepidermal water loss (TEWL), dermatological findings, and severity of itching. Each moisturizer was applied onto the bilateral forearm flexor surfaces with a chief symptom of dryness associated with subsiding skin inflammation twice daily for three weeks, followed by a one week observation period, during which no treatment was given to the target sites. All three moisturizers significantly increased the water content of stratum corneum during the application period. Of these, the heparinoid preparation yielded the highest water content of stratum corneum, and this effect lasted throughout the observation period as well. Dermatological findings and itching significantly improved with all moisturizers, but TEWL did not reduce. Thus, this study provides evidence for beneficial effects of all moisturizers studied on dermatophysiological dysfunction in AD patients and for a higher moisturizing efficacy of the heparinoid preparation than the urea preparation or petrolatum.
A 22-year-old man, who experienced anaphylactic shock during an orthopedic operation, was referred to our hospital for allergic tests. He also had histories of allergic rhinitis due to pollen, metal allergy, and unconfortable feelings when he ate some kinds of fruit. Intradermal reaction tests revealed a positive reaction to the generic version of cefazolin sodium, but not the original drug. Both drugs have the same main ingredient without any additive, but both of them have possible impurities derived from their manufacturing process, suggesting that the impurities contaminating only the generic drug may cause an anaphylactic reaction in our present case. Today, to reduce medical expenses, generic drugs is tend to be recommended. We should pay attention not only to the costs but also to the safety information about the drugs when we prescribe them to patients.
In order to evaluate the diagnostic accuracy of dermoscopy for malignant melanoma (MM) and basal cell carcinoma (BCC), we examined 974 cases examined by taken dermoscopy photography and confirmed by histological diagnosis from 1999 to 2005 in the Niigata Cancer Center Hospital. By dermoscopy evaluation, the sensitivity and specificity for the diagnosis of MM were 91% (69/76 cases) and 99% (886/897 cases),whereas the sensitivity and specificity for BCC were 92% (156/170 cases) and 97% (780/803 cases).The most frequent clinical diagnosis among the false negative cases was seborrheic keratosis. Dermoscopy showed a significantly higher sensitivity for the diagnosis of MM and BCC than naked-eye evaluation for these seven years. Therefore, it was confirmed that dermoscopy has a high utility for the clinical differential diagnosis of these two tumors.