The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
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Volume 133, Issue 9
Displaying 1-8 of 8 articles from this issue
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Original Articles
  • Two Cases of Harlequin Syndrome with Different Etiologies
    Tomoka Waseda, Yuta Koike, Shunsuke Yoshimura, Akira Tsujino, Hiroyuki ...
    2023 Volume 133 Issue 9 Pages 2161-2168
    Published: August 20, 2023
    Released on J-STAGE: August 20, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.2161
    JOURNAL RESTRICTED ACCESS
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    Case 1: A 47-year-old man presented with hyperhidrosis on the left side of his body and decreased sweating on the right side from the face to the chest as diagnosed by Minor's method. A subsequent neck MRI showed a mass at the right carotid bifurcation, which could compress the cervical ganglion that innervates the hyperhidrosis lesion. He was diagnosed with symptomatic Harlequin syndrome. Case 2: A 53-year-old woman with a history of Sjögren's syndrome presented with hyperhidrosis on the left side of the face and segmental anhidrosis diagnosed by Minor's method. Clinical examinations revealed no organic disease or underlying cause other than Sjögren's syndrome. Therefore, she was diagnosed with idiopathic Harlequin syndrome associated with Sjögren's syndrome. Harlequin syndrome, characterized by paroxysmal hemifacial flushing due to the face's contralateral segmental anhidrosis, sometimes arises in response to organic diseases such as tumors or autoimmune diseases such as Sjögren's syndrome. Such cases with asymmetrical hyperhidrosis require investigation to search for underlying conditions.

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  • Two Cases of Contact Dermatitis Caused by OSVAN S® (Benzalkonium Chloride) Laundry Deodorizer
    Mamiko Masuzawa, Mamiko Shono, Mika Nakamura, Noriko Suzuki, Yasuyuki ...
    2023 Volume 133 Issue 9 Pages 2169-2175
    Published: August 20, 2023
    Released on J-STAGE: August 20, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.2169
    JOURNAL RESTRICTED ACCESS
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    Benzalkonium Chloride (BAC), a quaternary ammonium cationic detergent and preservative in health care and household products, is a known irritant. We report two cases of patients who developed contact dermatitis after approximately one year of using diluted OSVAN S® (10%BAC) for deodorant treatment in laundry, as recommended by an internet resource. They presented with erythema and scaly pigmentation and pruritis and tenderness in intertriginous areas, especially those in close contact with underwear. Topical corticosteroid ointment treatment led to little improvement. In both cases, their cutaneous symptoms were improved by cessation of using BAC and wearing BAC-contaminated clothing. There have been similar cases reported from Australia and New Zealand that involve BAC in commercial laundly sanitizers, as described as "granular parakeratosis" or "hyperkeratotic flexural erythema". In Japan, BAC is not an ingredient in marketed laundry products. This is the first report of contact dermatitis caused by inappropriate BAC usage for laundry in Japan, and inspired by inaccurate information from the internet.

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