The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
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Volume 133, Issue 12
Displaying 1-9 of 9 articles from this issue
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Guidelines
Seminar for Medical Education
Original Articles
  • Association between Cutaneous Immune-related Adverse Events that Developed during Immune Checkpoint Inhibitor Treatment and Oncologic Outcomes
    Kinuko Irie, Maki Takada, Mai Endo, Takashi Ito, Masato Ishikawa, Aki ...
    2023 Volume 133 Issue 12 Pages 2825-2836
    Published: November 20, 2023
    Released on J-STAGE: November 20, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.2825
    JOURNAL RESTRICTED ACCESS
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    We retrospectively evaluated 110 patients who developed cutaneous symptoms during their immune checkpoint inhibitor treatment for various malignancies and compared the clinical classification of their symptoms, severity, and predictors of treatment response between those patients with a controlled primary malignancy (the effective treatment group) and those without (the disease progression group). Prevalence of vitiligo, asteatotic eczema and cutaneous immune-related adverse events (irAEs) as well as irAEs involving more than two organs were significantly higher in patients with a controlled primary malignancy. The comparison between the effective treatment group and the disease progression group showed that the former had higher lymphocyte counts before treatment and during the appearance of skin symptoms and lower neutrophil-lymphocyte ratios before and after the appearance of skin symptoms. Longitudinal hematologic analysis may provide a predictive indicator for skin lesions and treatment response.

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Review
  • JAK Inhibitors in the Treatment of Vitiligo
    Shintaro Inoue, Tamio Suzuki, Shigetoshi Sano, Ichiro Katayama
    2023 Volume 133 Issue 12 Pages 2837-2848
    Published: November 20, 2023
    Released on J-STAGE: November 20, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.2837
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    Vitiligo is an autoimmune disease involving melanocyte-damaging cytotoxic T cells in combination with environmental and genetic factors. Steroids and tacrolimus have been used as topical agents for its treatment, but new topical agents have recently emerged that target the tyrosine kinase family, Janus kinases (JAK), which regulate cytokine signaling. Ruxolitinib is already used for topical vitiligo treatment in the U.S.A. and is expected to be approved for vitiligo in Japan. Herein, we review why topical JAK inhibitors should be used for the treatment of vitiligo from the viewpoints of mechanism of action, efficacy, and safety.

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Letter to the Editor
  • A Case of Nummular Eczema of Breast after Mastectomy and Breast Reconstruction
    Atsuko Yano-Takamori, Akiko Sugiyama, Haruko Nishie, Takeshi Nakahara
    2023 Volume 133 Issue 12 Pages 2849-2852
    Published: November 20, 2023
    Released on J-STAGE: November 20, 2023
    DOIhttps://doi.org/10.14924/dermatol.133.2849
    JOURNAL RESTRICTED ACCESS
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    For right breast cancer, 42-year-old female underwent total right mastectomy and breast reconstruction with abdominal flaps in May 20XX, and two revisions in October 20XX+1 and November 20XX+2. In January 20XX+1, erythema appeared in part of the surgical scar of the right breast and showed a gradual tendency to expand, but no treatment intervention was provided. The edematous erythema invading the entire suture line of the right breast and hyperpigmentation with scaling around the erythema were diagnosed as nummular eczema, and topical steroid treatment was started. It is important for dermatologists to recognize that nummular eczema may occur after breast reconstruction surgery and to encourage moisturizing and early therapeutic intervention.

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