The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
Volume 127 , Issue 2
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Original Articles
  • Chie Doi, Yu Harada, Hiroshi Sakai, Keisuke Kawamoto, Takaya Fukumoto, ...
    2017 Volume 127 Issue 2 Pages 161-166
    Published: February 20, 2017
    Released: February 21, 2017
    JOURNALS RESTRICTED ACCESS

    A 50-year-old woman presented with a subcutaneous tumor extending from the right axilla to the scapula; she also had eosinophilia and nephrotic syndrome. The tumor was histopathologically diagnosed as mimic angiolymphoid hyperplasia with eosinophilia (ALHE).

    In the biopsy specimens from the skin and kidney, IgG4-positive plasma cells infiltrated, leading to the diagnosis of IgG4-related disease. IgG4-related disease and ALHE share the same Th2-skewing immunological condition. Our case indicates that subcutaneous ALHE is one of the skin manifestations that can be due to IgG4-related disease.

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