Carbonate apatite (CO
3Ap), fabricated by dissolution-precipitation reaction based on an appropriate precursor, is expected to be replaced by bone according to bone remodeling cycle. One of the precursor candidates is gypsum because it shows self-setting ability, which then enables it to be shaped and molded. The aim of this study, therefore, was to fabricate CO
3Ap blocks from set gypsum. Set gypsum was immersed in a mixed solution of 0.4 mol/L disodium hydrogen phosphate (Na
2HPO
4) and 0.4 mol/L sodium hydrogen carbonate (NaHCO
3) at 80–200°C for 6–48 h. Powder X-ray diffraction patterns and Fourier transform infrared spectra showed that CO
3Ap block was fabricated by dissolution-precipitation reaction in Na
2HPO
4-NaHCO
3 solution using set gypsum in 48 h when the temperature was 100°C or higher. Conversion rate to CO
3Ap increased with treatment temperature. CO
3Ap block containing a larger amount of carbonate was obtained when treated at lower temperature.
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