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Volume 108, Issue 4
Displaying 1-5 of 5 articles from this issue
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Yasushi ABIKO, Hiroko HASHIZUME, Akiyoshi HARA1996 Volume 108 Issue 4 Pages 195-202
Published: 1996
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe classical understanding of the mechanism of anti-anginal or anti-ischemic drugs is an increase in blood supply to the heart and/or a decrease in oxygen consumption of the heart, maintaining energy balance in the heart between supply and demand and hence maintaining the tissue levels of high-energy phosphates. This scheme is reasonable. During reperfusion following ischemia, however, there is more serious damage to the heart, although the tissue levels of highenergy phosphates increase. This is probably because toxic substances are generated in the heart during ischemia/reperfusion. We propose that both lysophosphatidylcholine and palmitoyl-L-carnitine that accumulate in the myocardium during ischemia/reperfusion are candidates for the toxic substances that accelerate ischemia/reperfusion damage to the heart. Therefore, drugs that have anti-lysophosphatidylcholine and/or anti-palmitoyl-L-carnitine effects are promising for the treatment of ischemic heart diseases. We found that K-7259, a novel derivative of dilazep having a minimal effect on the normal heart, is a drug that attenuates the deleterious effects of both lysophosphatidylcholine and palmitoyl-L-carnitine on the heart, and therefore attenuates the ischemia/reperfusion damage.View full abstractDownload PDF (1428K) -
Mitsuo MURAYAMA, Tsutomu MIURA, Hideo BANDO1996 Volume 108 Issue 4 Pages 203-216
Published: 1996
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSWe have developed a method using a laser flow meter for investigating the effect of compounds on peripheral blood flow. The differences of blood flow in several portions and areas of the probe of a laser flow meter in the mouse and the effect of solvents for dissolving compounds on the blood flow were observed. The results indicated that the invisible area of blood vessels at the back or hind paw of the mouse was the most suitable placement position for the probe. In these placement positions, none of the tested solvents, 0.9% physiological saline solution, dimethylsulfoxide and 50% ethanol, had any significant effect on the peripheral blood flow. Next, using this method, we determined how the peripheral blood flow is affected by several drugs active on the circulatory system. By comparison between the present results from mice and previously reported data from other animals, it was shown that the effects of these cardiovascular agents on the peripheral blood flow in mouse skin showed similar tendencies to those in the previous reports using larger animals and sites other than the skin. However, a few of the drugs used in this experiment showed characteristic action on the peripheral blood flow in mice. Consequently, it was demonstrated that this method using the laser flow meter was useful as a simple first screening method to evaluate the effect of a compound on the peripheral blood flow.View full abstractDownload PDF (6331K) -
Muneto MATSUTA, Rie KANITA, Fumiko TSUTSUI, Akira YAMASHITA1996 Volume 108 Issue 4 Pages 217-225
Published: 1996
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSRecently it has been reported that Shosaiko-to (SHO), a traditional Chinese medicine used for treating gastritis and hepatitis, also has been found useful for treating gastric ulcers, although no pharmacological study has yet investigated the precise antiulcer properties of SHO. Herein, the authors report on the results of a rat study in which the effects of SHO on gastric ulcers, acid secretions and potential difference of gastric mucosa (PD) were studied. SHO (100, 250 or 500 mg /kg, p.o.) significantly inhibited the development of ethanol-induced gastric lesions in a dosedependent manner. SHO (500 mg/kg, p.o.) significantly inhibited the development of aspirin-, indomethacin-or water-immersion-stress induced gastric lesions. Sucralfate (500 mg/kg, p.o.) inhibited both ethanol-and aspirin-induced gastric lesions, and cimetidine (10 mg/kg, p.o.) inhibited aspirin-, indomethacin-or stress-induced gastric lesions. SHO (10, 30 and 100 mg/kg, i.p.) also significantly inhibited pentagastrin- and 2-deoxy-D-glucose (2-DG) -induced gastric acid secretions in a dose-dependent manner, whereas cimetidine (1 mg/kg, i.p.) inhibited a pentagastrininduced secretion and atropine (0.05 mg/kg, i.p.) inhibited pentagastrin-or 2-DG-induced acid secretions. SHO (250, 500 or 1000 mg/kg, i.g.) significantly inhibited ethanol-induced PD reduction. Sucralfate (500 mg/kg, i.g.) inhibited the reduction, and cimetidine (250 mg/kg, i.g.) didn't inhibit it. These results indicate that SHO not only possesses the capability of protecting the rat gastric mucosa as well as sucralfate, but also is able to inhibit gastric acid secretions like cimetidine or atropine.View full abstractDownload PDF (5103K) -
1996 Volume 108 Issue 4 Pages b63-b82
Published: 1996
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSDownload PDF (4356K) -
1996 Volume 108 Issue 4 Pages b83-b106
Published: 1996
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSDownload PDF (5313K)
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