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Volume 92 (1988)
- Issue 6 Pages 337-
- Issue 5 Pages 271-
- Issue 4 Pages 201-
- Issue 3 Pages 167-
- Issue 2 Pages 61-
- Issue 1 Pages 1-
Volume 92, Issue 3
Displaying 1-4 of 4 articles from this issue
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Hidekazu ARATANI, Tomonori IMAYOSHI, Yukari NISHIDA, Michio TERASAWA, ...1988 Volume 92 Issue 3 Pages 167-174
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSEthylcysteine showed a prophylactic effect on collagen-induced arthritis in rats at 100 mg/kg, p.o., and the effect continued even after stopping the administration. However, it was not dose-dependent. D-penicillamine showed no effect under the same condition. Ethylcysteine tended to inhibit collagen-induced arthritis when it was administered therapeutically at 300 mg/kg, p.o. Moreover, it had little effect on the acute inflammatory and type I allergy models such as carrageenin induced edema, 48 hr homologous PCA, and 6 hr and 24 hr Evans blue-carrageenin pleurisy in rats. In the in vitro assay, ethylcysteine had the following effects : inactivation of the rheumatoid factor, the acceleration of the denaturation of human γ-globulin and the inhibition of bone alkaline phosphatase. The effect were as potent as those of D-penicillamine. As to the results, the mode of action of ethylcysteine is the same as that of D-penicillamine in terms of the biochemical properties. However, ethylcysteine showed an inhibitory effect on collagen-induced arthritis which was not demonstrated with D-penicillamine, so this drug may have a clinically anti-rheumatic action.View full abstractDownload PDF (5772K) -
Hiroshi KUSAMA, Masahiko NISHIYAMA, Shigeru IKEDA1988 Volume 92 Issue 3 Pages 175-180
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSThe hypolipidemic effects of bezafibrate were examined in normal rats and an experimentally induced hyperlipidemic model of rats. Oral administration of bezafibrate at 1 mg/kg/day or more to normal rats for 7 days significantly decreased serum triglyceride (TG) and at 3 mg/kg/day or more for 7 days caused significant reduction of serum total cholesterol (TC). A single oral dose of 100 mg/kg of bezafibrate significantly inhibited the increase of serum TC and TG in hyperlipidemic rats induced by Triton WR-1339. When normal rats were given 75% fructose solution for 7 days, serum TG increased in concentration about four times. Oral administration of bezafibrate for 7 days at 1 mg/kg/day or more inhibited the increase of serum TG in this model. Serum TC increased in concentration about twice in 1 % cholesterol diet-fed rats for 8 weeks. Oral administration of bezafibrate at 30 mg/kg/day or more inhibited the increase of serum TC. These results suggest that bezafibrate is effective in the treatment of hyperlipidemia.View full abstractDownload PDF (4489K) -
Hiroshi KUSAMA, Masahiko NISHIYAMA, Yasuhito MATSUBARA, Shigeru IKEDA1988 Volume 92 Issue 3 Pages 181-191
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSThe mechanism of the hypolipidemic action of bezafibrate was investigated in rats. Bezafibrate decreased the incorporation of 14C-acetic acid into the liver and serum triglyceride and inhibited liver acetyl CoA carboxylate activity. Bezafibrate increased liver β-oxidation, but it had no effect on lipolysis and triglyceride secretion from the liver. Bezafibrate accelerated the elimination of serum triglyceride in Intralipid® injected rats and increased tissue lipoprotein lipase activity. Bezafibrate decreased the incorporation of 14C-acetic acid into liver cholesterol and inhibited liver HMG-CoA reductase activity. Bezafibrate had no effect on cholesterol absorption and excretion. These results suggest that the hypotriglyceridemic actions of bezafibrate are due to inhibition of triglyceride synthesis and acceleration of triglyceride elimination and that the hypocholesteridemic action of bezafibrate is mainly due to inhibition of liver HMG-CoA reductase activity.View full abstractDownload PDF (8422K) -
Kazuyoshi BANDO, Yoshikazu HATANAKA, Shigeo OHBAYASHI, Osamu IRINO1988 Volume 92 Issue 3 Pages 193-200
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSA method for measuring the organic infarct focus induced by arachidonate infusion into rat brain was devised, and the statistical relationship between the measured values and stroke signs in the rat was studied. By the infusion of arachidonate, a high incidence of cerebral infarction was found in the live rats with uniformly necrotized foci. The size of these foci (infarction rate) were measured by transcripting them to a graduated brain sheet. The relationship between the independent parameter of the infarction rate and the dependent parameter of stroke signs was fully analyzed by multidimensional quantification. Many animals showed no stroke signs despite having lesions (false negative). By contract, no animal without any lesion showed stroke signs (false positive). When each parameter of these signs were quantified and normalized, the stumbling and abnormal posture signs showed a wide range of values, relatively accurately reflecting the infarction degree. Moreover, the highest partial correlation ratio between the various parameters was found to be that between the stumbling and abnormal posture stroke signs. Thus, it may be said that the stumbling and the abnormal posture stroke signs can be considered relatively good parameters for evaluating the degree of an infarction. These parameters should be useful for the testing of anti-infarction drugs.View full abstractDownload PDF (6870K)
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