All issues
Volume 66 (1970)
- Issue 6 Pages 607-
- Issue 5 Pages 471-
- Issue 4 Pages 387-
- Issue 3 Pages 293-
- Issue 2 Pages 177-
- Issue 1 Pages 1-
Volume 66, Issue 4
Displaying 1-10 of 10 articles from this issue
- |<
- <
- 1
- >
- >|
-
Tetsuo SATOH, Soichi YOSHIDA, Yasumi OGURA, Kayoko MOROI1970 Volume 66 Issue 4 Pages 387-393
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSCorrelation between cholinesterase (ChE) inhibition, miosis and tryptophan pyrrolase (TP) activity in EPN-treated rats was investigated, and following results were obtained.
1) Inhibit ion of serum ChE was initiated at 1h and continued untill 24h after EPN administration, however, maximum response of miosis and increase in TP activity were observed 6h after treatment and gradually recovered to initial levels within 24h. These observations indicated that ChE inhibition was evoked prior to changes in pupil reaction and TP activity.
2) Increase in TP activity was inhibited by pretreatment with either β-adrenergic blockers, propranolol and DCI or atropine and PAM, moreover, adrenalectomy abolished completely the increase in TP activity. It is likely, therefore, that administration of EPN did stimulate the secretion of glucocorticoid from adrenals through autonomic nervous system.View full abstractDownload PDF (2823K) -
Approach to the screening test in vitro of nonsteroidal anti-inflammatory drugsYoshio AIZAWA, Morio IWASAKI1970 Volume 66 Issue 4 Pages 394-399
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSThe inhibitory action of nonsteroidal anti-inflammatory drugs on the ATPase activity and inflammatory edema were studied.
The inhibitory rate of ATPase activity and inflammatory edema by nonsteroidal anti-inflammatory drugs were well correlated.View full abstractDownload PDF (2802K) -
Tomio SEGAWA, Isami KURUMA, Katsuya TAKATSUKA, Hiroshi TAKAGI1970 Volume 66 Issue 4 Pages 400-407
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSSubcellular distribution of 5-hydroxytryptamine (5-HT) in rabbit brain stem was investigated by the technique of differential and density-gradient centrifugation. The present study confirmed the finding that 5-HT was principally found in crude mitochondrial fraction (P2). Further subfractionation of P2-fraction revealed that the high concentration of 5-HT was found in P2B- and P2V-fraction although considerable amount of 5-HT was also found in P2D- and P2S-fraction. Electron microscopic examination showed that P2- and P2V-fraction consisted largely of nerve-ending particles and synaptic vesicles, respectively.View full abstractDownload PDF (4392K) -
Mamoru SUZUKI, Yasuteru TOYOSHIMA1970 Volume 66 Issue 4 Pages 408-416
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSThe increased capillary permeability (and non-blued area) produced by the intracutaneous injection of alcohols in rabbits were investigated.
1) The ch ange of permeability by dihydric alcohols (C2 to C6) were proportional to the length of their carbon chain.
2) The increased permeability and the size of non-blued area were inversely proportional to the numbers of hydroxyl residue in lower alcohols.
3) There were not or scarcely differences among the responses formed by some position isomers of dihydric alcohols.
4) Polyoxyethylene glycols of various molecular weights at a constant molar concentration leaded the indistinguishable extents of the increased permeability, and a similar relationship was found in the formation of non-blued area by these glycols at a same concentration in percent.
5) The pretreatment of diphen hydramine inhibited partialy the increase of permeability by lower alcohols, but not those by higher alcohols.
6) The increse of permeability by alcohols was not effected by the pretreatment of salicylate, glycyrrhizin and cortisone.
7) The change of permeability by alcohols seemed to be related with their oil-water partition coefficient and their surface activity.
8) The mechanisms on local action of alcohols were discussed from the results in previous and this papers.View full abstractDownload PDF (4237K) -
Masafumi KOBAYASHI, Motooki IMAI, Masayuki HORIBE, Mitsuaki SANO, Hisa ...1970 Volume 66 Issue 4 Pages 417-426
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSPrevious works showed that isolation induced hyperactivity of brain ChE of mice.
Present study was carried out by measuring the effect of exogenous ACTH on such hyperactivity and aggressiveness induced by isolation.
Male albino D. D. O mice weighing 15 g were employed through all the experiments. Each animal was put in plastic cage for a period of 8 weeks. The size of cage for isolation is 10×10×11 cm and for aggregation (5 animals for a cage) is 19×12×12 cm. The walls were painted in black in such a way that the animals could not have visual contacts. Animals were fed a normal balanced diet “ad libitum” and administered with following drugs every two days.
Experimental gr oups were consisted as the following;
A) Isolated mice
1) The group administered with ACTH (10 J. P. U./kg i. p.) ?? ACTH-A
2) The group administere d with solvent of ACTH (i. p.) ?? Controls-A
B) Aggregated mice
1) The group administered with ACTH (10 J. P. U./kg i. p.) ?? ACTH-B
2) The group administere d with solvent of ACTH (i. p.) ?? Controls-B
The degree of aggressi veness was evaluated according to the method described by Allee-Scott and from such degree animals were classified into “victorious mice” and “defeated mice.” The test was performed every Saturday for a period. At the end of the period of isolation and aggregation animals were decapitated in different times (0′, 15′, 30′, 60′, 120′ after eserine treatment (0.2 mg /kg i. p.) and biochemical procedure were carried out in these brains by measuring ChE activity with the method described by Hesterin.
Results;
1) The relation between the period of isolation and aggressiveness:
Aggressiveness of ACTH-A was markedly enhanced up to 6 th week of isolation and after this week such enhancement was slowley become, while aggressiveness of controls-A was rapidly elevated up to 8 th week of isolation and after this week such rapidity was markedly declined.
2) The influence of isolation on body weight:
Body weights of the aggregated mice of both group were found to be significantly lower than the isolated mice of which the victorious mice were significantly greater than the defeated mice in either case.
3) Brain ChE activity:
a) Hyperactivity of bra in ChE in isolated mice were found in either case.
a) Hyperactivity of brain ChE in isolated mice were found in either case.
b) Administration of ACTH declined this enzymatic activity in different degree in either isolation or aggregation.
c) Isolation of mice inhibited slightly the effect of eserine on above enzymatic activity.View full abstractDownload PDF (3084K) -
Effects on various preparationsYukio ISHIDA, Hideki MORITOKI1970 Volume 66 Issue 4 Pages 427-434
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSIn previous papers, the potentiating effect of choline to the contractile action of phenylacetate was found on the isolated guinea-pig ileum. In this paper, this potentiating effect was examined on other isolated preparations, such as other each part of gut, vas deferens and taenia coli of guinea-pig, uterus and stomach fundus of rat and frog rectus. It was showed that phenylacetate with choline were able to produce the contractile responses on all these preparations on which ACh had responses, and then the blood depressor action in dog which seemed ACh-like response. It was supposed that the mechanism of responses produced by phenylacetate with choline might be the formation of ACh or releasing ACh. These phenomena were named Acetate-Choline coupling (Ac-Ch coupling) responses.View full abstractDownload PDF (3357K) -
Mutual relation in the convulsion of El-mice and central-acting drugsTaeko HATA, Tetsuo MURAKAMI, Tomitaro KITA1970 Volume 66 Issue 4 Pages 435-441
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSMutual relation in inducing convulsion between 2 or among 3 El-mice were brought to a conclusion from many cases, and it was found that there was a reasonable relationship between the simultaneity and non-convulsion in El-convulsion.
The influence of centra l-acting drugs to the relation was investigated when El-mice were administered a little of the drug which dose not show general pharmacological actions at all.
In consequence, the simultaneity increased in administration of central stimulants, and to the contrary it decreased and the rate of non-convulsion increased in administration of central depressants.
However in administratio n of DL-amphetamine, the mutual relation between 2 El-mice went wide from the normal distribution area, besides focused upon a limited area.View full abstractDownload PDF (2665K) -
Sadayuki SHO, Hiroyasu KINEMUCHI, Toru EGASHIRA, Masako SEKI, Momoko Y ...1970 Volume 66 Issue 4 Pages 442-448
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSMonoamine oxidase (MAO) in hog kidney was found mainly in mitochondrial fraction and about 60 % of the enzyme in mitochondria was solubilized by a treatment of 1 % sodium cholate and ammonium sulfate fractionation. The specific activity of purified MAO was about 10-fold than that of the homogenate. PS maximum of the purified MAO was found at 2.0 and pH optimum was found at 8.0 in case of tyramine used as substrate. The administration of Fe++ and Cu++ in the system caused inhibition, however, NaN3 caused marked activation of the enzymic activity.View full abstractDownload PDF (2944K) -
Tomitaro KITA, Taeko HATA, Tetsuo MURAKAMI1970 Volume 66 Issue 4 Pages 449-457
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSSome factors inducing the convulsion of El-mice were investigated about movement, sex or time.
In consequenc e, it appears that shaking-stimuli after appearence of the seizure acted suppressively to the convulsion of El-mice.
The threshold of shaking-number for convulsion (abbreviated TSC) in female El-mice were smaller than in male Elmice, and that the convulsion of El-mice occured easily rather on female mice than on male mice. TSC was smaller at evening than at morning and it was remarkable especially on female mice.
The simultaneity of the convulsion between 2 mice or among 3 mice was also lager in female mice than in male mice.View full abstractDownload PDF (3026K) -
Takeshi ONODERA, Akira KASAHARA, Masanao ISHIHARA, Hidemasa OGAWA, Yas ...1970 Volume 66 Issue 4 Pages 458-469
Published: 1970
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSFurazabol, a new anabolic steroid, inhibited a rise in cholesterol levels in the serum and liver induced by cholesterol feeding, although its effects on phospholipids, triglycerides, and free fatty acids were not marked. Fatty acid compositions of serum esterified cholesterol and triglycerides were not so much affected by the furazabol treatment. Furazabol has been expected to possess the therapeutic effect on atherosclerosis, that is, the progression of atheromatous changes was significantly inhibited by the treatment with this compound. In addition, furazabol clearly lightened fatty degeneration of the liver.View full abstractDownload PDF (5938K)
- |<
- <
- 1
- >
- >|