All issues
Volume 95 (1990)
- Issue 6 Pages 279-
- Issue 5 Pages 229-
- Issue 4 Pages 139-
- Issue 3 Pages 83-
- Issue 2 Pages 47-
- Issue 1 Pages 7-
Volume 95, Issue 2
Displaying 1-3 of 3 articles from this issue
- |<
- <
- 1
- >
- >|
-
Yukihiro OZAKI1990 Volume 95 Issue 2 Pages 47-54
Published: 1990
Released on J-STAGE: February 20, 2007
JOURNAL FREE ACCESSVasodilative effects of hirsutine (HS) and hirsuteine (HST) which were isolated from the domestic plant Uncaria rhynchophylla MiQ. and β-yohimbine (β-Y) which was isolated from the domestic plant Amsonia elliptica ROEM. et SCHULT. were carried out. In the hind-limb artery of anesthetized dogs, intra-arterial administration of HS, HST and β-Y caused a vasodilatation. The vasodilative potency of HS was somewhat stronger than that of HST, and the potency of both alkaloids was approximately equal to that of papaverine. The vasodilative effect of β-Y was similar to that of yohimbine, which is considered to be derived from its α-adrenoceptor blocking effect, and the potency of both alkaloids was approximately the same, while the effect of β-Y was stronger than that of papaverine. In the coronary artery, HS showed a vasodilatation and its potency was weaker than that of papaverine. Also, HS showed the same effect in the cerebral artery, and the potency of HS was approximately the same as that of papaverine. These results suggest that the mode of the vasodilative effect induced by HS may partly differ from that of papaverine.View full abstractDownload PDF (5374K) -
Shigeru KANEKO, Kenji KITAZATO, Yasuhide YAMAZAKI, Hiromasa OKADA, Mas ...1990 Volume 95 Issue 2 Pages 55-61
Published: 1990
Released on J-STAGE: February 20, 2007
JOURNAL FREE ACCESSThe effect of propiverine hydrochloride (P-4) on the function of the bladder in decerebrated dogs was compared with that of propantheline, an anticholinergic drug which is used for the treatment of micturitional disorders. P-4 (5 and 10 mg/kg, i.v.) significantly increased maximum vesical volume (Vmax) ; and at the dose of 10 mg/kg, i.v., it also significantly increased effective vesical volume (EV) when determined by cystometry. However, at the dose level of 2, 5 and 10 mg/kg, i.v., P-4 had no effect on residual volume (RV) after micturition contraction. Propantheline (0.25 and 0.5 mg/kg, i.v.) also significantly increased Vmax, but showed no effect on EV. At doses higher than 0.016 mg/kg, i.v., propantheline significantly. increased RV. These findings indicate that P-4 is a useful drug for the treatment of pollakiuria.View full abstractDownload PDF (5317K) -
Naohiko ONO, Noriyuki YAMAMOTO, Akihiko SUNAMI, Yasundo YAMASAKI, Hide ...1990 Volume 95 Issue 2 Pages 63-81
Published: 1990
Released on J-STAGE: February 20, 2007
JOURNAL FREE ACCESSPharmacological activities of mofezolac were investigated in experimental animal models and compared with those of indomethacin, ibuprofen, mefenamic acid, aspirin and aminopyrine. Mofezolac showed a potent suppression of various writhing models in mice or rats; and its potency was slightly lower than that of indomethacin, but was higher than those of the other reference drugs. Thus, mofezolac was especially active against chemically induced writhing and also in the phenylquinone induced intraperitoneal dye leakage reaction in mice. Mofezolac also has a potent inhibitory activity on the algesic responses induced by the mechanical stimulus of the inflammed tissue. Mofezolac exhibited a therapeutic effect comparable to indomethacin in the urate synovitis in dogs. Considering the anti-inflammatory and antipyretic actions, mofezolac was obviously less effective than indomethacin, and its potency was similar to that of ibuprofen. The ulcerogenic effect of mofezolac on the gastric mucosa was far weaker than that of indomethacin. In in vitro studies, the prostaglandin biosynthesis and platelet aggregation were inhibited to the same extent by both mofezolac and indomethacin. Accordingly, it may be considered that the actions of mofezolac are due to the inhibition of cyclooxygenase. Our result suggest that mofezolac can be a useful drug that shows a rapid pain-relieving activity in acute inflammations.View full abstractDownload PDF (11439K)
- |<
- <
- 1
- >
- >|