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Volume 79 (1982)
- Issue 6 Pages 461-
- Issue 5 Pages 343-
- Issue 4 Pages 237-
- Issue 3 Pages 113-
- Issue 2 Pages 77-
- Issue 1 Pages 1-
Volume 79, Issue 2
Displaying 1-4 of 4 articles from this issue
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Toshinori OHMIYA, Osamu SHIBATA, Shunichi MAEMURA, Masami NIWA, Masayo ...1982Volume 79Issue 2 Pages 77-84
Published: 1982
Released on J-STAGE: March 09, 2007
JOURNAL FREE ACCESSThe rate of secretion of dopamine (DA) was investigated along with those of norepinephrine (NE) and epinephrine (E) in the case of hemorrhagic hypotension. Blood samples were collected directly from the adrenal vein and DA, NE and E contents were measured using a gas-liquid chromatograph equipped with an electron capture detector (GLC-ECD). Under the condition of hemorrhagic hypotension, the rates of secretion of DA, NE and E increased from 0.22, 3.4 and 13.7 ng/kg/min to 10.7, 89.7 and 361.4 ng/kg/min in 90 min, respectively. After reinfusion, the levels of DA, NE and E decreased. The concentration of DA in the femoral artery was 1.0 and 1.5 ng/ml at 70 and 90 min after hemorrhage. In spinal transected preparations, increases in the rates of DA, NE and E secretion did not occur during hemorrhagic hypotension. Thus, the rates of secretion of DA, NE and E varies with the hemodynamic changes, the secretion of DA from the adrenal gland is primarily controlled by the central nervous system, and the pattern of increase in level of DA differs from the patterns in the case of NE and E in hemorrhagic hypotension.View full abstractDownload PDF (3589K) -
Hirohiko SAKAMOTO, Kazuko INOUE, Tamotsu MURATA, Shigekatsu KOHNO, Kat ...1982Volume 79Issue 2 Pages 85-92
Published: 1982
Released on J-STAGE: March 09, 2007
JOURNAL FREE ACCESSThe antinociceptive activity of guanabenz, a new potent antihypertensive agent, and its interaction with α-adrenoceptors or opiate receptors, with particular reference to clonidine and morphine, were studied. Guanabenz, clonidine and morphine were found to possess a dose-dependent antinociceptive activity in mice and rats. In the tail flick assay, the antinociceptive activity of guanabenz and clonidine was antagonized by yohimbine but not by naloxone or phenoxybenzamine. Guanabenz, clonidine and morphine caused a concentration-dependent inhibition of the twitch response of transmurally stimulated guinea-pig ileum longitudinal muscle. Phentolamine and yohimbine reversed the twitch-inhibitory effects of guanabenz and clonidine, but naloxone failed to reverse this action. Guanabenz and low doses of clonidine caused locomotor hypoactivity. This action of both drugs was affected by yohimbine but not by phenoxybenzamine. In contrast, a high dose of clonidine caused locomotor hyperactivity which was affected by phenoxybenzamine but not by yohimbine. These results suggest that the antinociceptive activity of guanabenz, as in the case of clonidine, may be mediated by the activation of α2-adrenoceptors and be independent from opiate receptors.he case of NE and E in hemorrhagic hypotension.View full abstractDownload PDF (4308K) -
Mamoru TERADA, Motohito SANO, Akira I. ISHII, Hideto KINO, Seigo FUKUS ...1982Volume 79Issue 2 Pages 93-103
Published: 1982
Released on J-STAGE: March 09, 2007
JOURNAL FREE ACCESSEffects of tuberostemonine (TS), an alkaloid from Stemona japonica, on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) TS (6.7 × 10-6 ?? 2 × 10-5M) paralyzed the motility of Angiostrongylus cantonensis. 2) TS (6.7 × 10-5M) showed contractive effects on the motility of Dipylidium caninum and Fasciola hepatica. 3) Treatment with TS (6.7 × 10-5 ?? 4.8 × 10-4M) had little effect on the motility of Schistosoma japonicum. 4) TS (6.7 × 10-5M) paralyzed the motility of the mouse isolated ileum preparation. 5) TS (6.7 × 10-7 ?? 6.7 × 10-6M) stimulated the twitch response induced by guanidine (2.5 × 10-3M) in the frog isolated rectus preparation. 6) Eserine and TS acted antagonistically on all preparations with the exception of S. japonicum. 7) TS and strychnine were antagonistic in isolated host tissues, whereas these compounds acted similarly on parasitic helminths. Thus, it is suggested that some of the experiential effects of the crude extracts of Stemona such as the anthelmintic effects are caused through the action of TS on parasitic helminths and host tissues.View full abstractDownload PDF (4632K) -
Mamoru TERADA, Motohito SANO, Akira I. ISHII, Hideto KINO, Seigo FUKUS ...1982Volume 79Issue 2 Pages 105-111
Published: 1982
Released on J-STAGE: March 09, 2007
JOURNAL FREE ACCESSEffects of N-methylcytisine (N-MC) and matrine (Mat), alkaloids from Sophora flavescens on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. I) The motility of Angiostrongylus cantonensis was affected spastically by N-MC (1.2 × 10-6 ?? 1.2 × 10-4M), but paralytically by Mat (10-5 ?? 10-4M). 2) The motility of Dipylidium caninum and Fasciola hepatica was affected paralytically by N-MC (1.2 × 10-4 ?? 1.2 × 10-3M), but spastically by Mat (10-4 ?? 10-3M). 3) Treatment with N-MC (10-3M) and Mat (8 × 10-4M) had little effect on the motility of Schistosoma japonicum. 4) Both N-MC (1.2 × 10-5 ?? 2.4 × 10-5M) and Mat (10-4M) stimulated the twitch response induced by guanidine (2.5 × 10-3M) in the frog isolated rectus preparation. 5) The motility of the mouse isolated ileum preparation was affected paralytically by N-MC (1.2 × 10-5 ?? 1.2 × 10-4M), but spastically by Mat (10-4 ?? 10-3M). Thus, N-MC and Mat acted antagonistically on all the preparations with the exception of the frog rectus preparation. From the results on interactions between these alkaloids and known neuropharmacological agents, it is suggested that the effects of both alkaloids are elicited through a neuropharmacological mechanism in parasitic helminths and host tissues.View full abstractDownload PDF (3128K)
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