Folia Pharmacologica Japonica
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
Volume 100, Issue 6
Displaying 1-4 of 4 articles from this issue
  • Tomoaki SHIRAO, Kunihiko OBATA
    1992 Volume 100 Issue 6 Pages 465-473
    Published: 1992
    Released on J-STAGE: February 13, 2007
    JOURNAL FREE ACCESS
    There have been many studies to determine extrinsic factors that may regulate the neuronal migration and growth of axons and dendrites. However, the intracellular mechanism, especially the regulation of cytoskeleton, has not been clarified. It has been reported that actin filament crosslinking protein, MARCKS, play roles in cell motility through cytoskeletal rearrangement accompanied by rapid, PKC-dependent phosphorylation. Recently, we have demonstrated that neuron-specific actin binding protein, drebrin, changed the stability and distribution of microfilaments within the fibroblast and formed highly-branched dendrite-like cell processes from their cell perimeters. It has also been reported that overexpression of microtubule associated protein, tau, in a fibroblast induced long axon-like cellular processes. This review will focus on dynamic regulations of the microfilament by drebrin and those of the microtubules by MAP2 and tau. Since all kinds of cytoskeletons are related to each other, the binding ability of neurofilament H to microtubules and that of MAP2 to neurofilaments were also discussed.
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  • Toshihiko UEMATSU
    1992 Volume 100 Issue 6 Pages 475-483
    Published: 1992
    Released on J-STAGE: February 13, 2007
    JOURNAL FREE ACCESS
    The human scalp hair is a useful tissue that retains the past dosage history over a rather long period of time, acting like a “tape-recorder”. It should be emphasized that the sampling of hair can be made noninvasively by cutting a few to several pieces of hair nearest to the scalp. Because the hair continues to grow at the rate of about 1 cm/month, each 1-cm hair length contains the drug corresponding to the amount ingested over a 1-month period when the hair is cut into 1-cm lengths successively from the scalp end. However, the hair growth rate is variable both within and between individuals, and the hair has its own growth cycle, i.e., 2 to 8 years or more of the growing stage and a few months of the resting stage. Therefore, the validity of the obtained results must always be considered cautiously, especially in relation to whether a resting phase hair might have been sampled. For obtaining information on the growth rate and stage of a hair, a drug that can be detected in the hair even after a short-term exposure to the drug has been found. These drugs are antimicrobial quinolones such as ofloxacin. By analyzing the axial distribution of ofloxacin along the hair shaft, we can expect to determine the so-called “tape-speed” and “uniformity of tape-running” of a single hair.
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  • Naosuke MATSUURA, Hiroshi MORI, Hiroichi NAGAI, Akihide KODA
    1992 Volume 100 Issue 6 Pages 485-493
    Published: 1992
    Released on J-STAGE: February 13, 2007
    JOURNAL FREE ACCESS
    We examined the effects of suplatast tosilate (IPD-1151T) on antibody formation in mice, and the following results were obtained: 1) IPD-1151T clearly increased the productions of IgM and IgG-hemolytic plaque forming cells (PFC) in mice immunized with sheep red blood cells (SRBC) when the agent was given p.o. for 5 days from the day of immunization. 2) IgM and IgG-PFC productions in old mice, 60 weeks of age, were clearly lower than those in adult mice, 10 weeks of age; and an oral administration of IPD-1151T significantly recovered the decayed PFC-production in the old mice. 3) IPD-1151T clearly suppressed the production of anti-dinitrophenyl (DNP)-IgE antibody in mice when the agent was given p.o. for 5 days from the day of immunization, whereas the agent did not affect antiDNP-IgM and IgG antibody productions. 4) IPD-1151T did not affect the induction phase of the cellular immune reaction of picryl chloride-induced contact dermatitis and the SRBC-induced footpad reaction. Our present results suggest that IPD-1151T has a class-specific suppressive effect on the production of IgE antibody, but does not suppress the other immune responses.
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  • Naosuke MATSUURA, Hiroshi MORI, Hiroichi NAGAI, Akihide KODA
    1992 Volume 100 Issue 6 Pages 495-501
    Published: 1992
    Released on J-STAGE: February 13, 2007
    JOURNAL FREE ACCESS
    We examined the effect of suplatast tosilate (IPD-1151T), which exhibits a class-specific suppression of IgE antibody production, on types I ?? IV allergic reactions. 1) Type I reaction : IPD-1151T dose-dependently inhibited 48-hr homologous passive cutaneous anaphylaxis (PCA) when the agent was given p.o. 30 min prior to the antigen challenge. To observe the time course of the inhibitory activity, IPD-1151T in a dose of 50 mg/kg was given orally at various times prior to the antigen challenge. IPD-1151T showed inhibitory activity when it was given at 0.5 to 2 hr prior to the antigen challenge, and the maximum inhibition was found when the IPD-1151T pretreatment was 2-hr before the challenge. IPD-1151T also suppressed the antigen-induced degranulation of mesenteric mast cells and histamine release from peritoneal exudate cells of rats. 2) Type II reaction: Only a high dose of IPD-1151T given orally inhibited reversed cutaneous anaphylaxis in rats, whereas the agent did not affect Forssman shock in guinea pigs. 3) Types III and IV reactions: IPD-1151T neither affected the Arthus reaction in rabbits nor the picryl chloride-induced contact dermatitis and sheep erythrocytes-induced footpad reaction in mice. The results obtained here indicate that IPD-1151T shows a relatively specific suppression of the type I allergic reaction with the inhibition of degranulation and histamine release from mast cells.
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